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Evaluation of status of toxic metals in biological samples of diabetes mellitus patients.
Diabetes Res Clin Pract. 2008 May; 80(2):280-8.DR

Abstract

There is accumulating evidence that the metabolism of several trace elements is altered in diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progress of this disease. The aim of present study was to compare the level of toxic elements, lead (Pb), cadmium (Cd), and arsenic (As) in biological samples (whole blood, urine, and scalp hair) of patients having diabetes mellitus type-2 age ranged (31-60) (n=238), with those of age matched non-diabetics (ND) as control subjects (n=196), of both genders. The concentrations of elements were measured by means of an atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy was checked by conventional wet acid digestion method and using certified reference materials. The overall recoveries of all elements were found in the range of 98.1-99.4% of certified values. The results of this study showed that the mean values of Pb, Cd and, As were significantly higher in scalp hair samples of smoker and non-smoker diabetic patients as compared to control subjects (p<0.001). The concentration of understudy toxic metals was also high in blood and urine samples of DM patient but difference was more significant in smoker DM patients. These results are consistent with those obtained in other studies, confirming that toxic metals may play a role in the development of diabetes mellitus.

Authors+Show Affiliations

National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18276029

Citation

Afridi, Hassan Imran, et al. "Evaluation of Status of Toxic Metals in Biological Samples of Diabetes Mellitus Patients." Diabetes Research and Clinical Practice, vol. 80, no. 2, 2008, pp. 280-8.
Afridi HI, Kazi TG, Kazi N, et al. Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Res Clin Pract. 2008;80(2):280-8.
Afridi, H. I., Kazi, T. G., Kazi, N., Jamali, M. K., Arain, M. B., Jalbani, N., Baig, J. A., & Sarfraz, R. A. (2008). Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Research and Clinical Practice, 80(2), 280-8. https://doi.org/10.1016/j.diabres.2007.12.021
Afridi HI, et al. Evaluation of Status of Toxic Metals in Biological Samples of Diabetes Mellitus Patients. Diabetes Res Clin Pract. 2008;80(2):280-8. PubMed PMID: 18276029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Kazi,Naveed, AU - Jamali,Mohammad Khan, AU - Arain,Mohammad Balal, AU - Jalbani,Nusrat, AU - Baig,Jameel Ahmed, AU - Sarfraz,Raja Adil, Y1 - 2008/02/13/ PY - 2007/04/27/received PY - 2007/12/31/accepted PY - 2008/2/16/pubmed PY - 2008/8/7/medline PY - 2008/2/16/entrez SP - 280 EP - 8 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 80 IS - 2 N2 - There is accumulating evidence that the metabolism of several trace elements is altered in diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progress of this disease. The aim of present study was to compare the level of toxic elements, lead (Pb), cadmium (Cd), and arsenic (As) in biological samples (whole blood, urine, and scalp hair) of patients having diabetes mellitus type-2 age ranged (31-60) (n=238), with those of age matched non-diabetics (ND) as control subjects (n=196), of both genders. The concentrations of elements were measured by means of an atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy was checked by conventional wet acid digestion method and using certified reference materials. The overall recoveries of all elements were found in the range of 98.1-99.4% of certified values. The results of this study showed that the mean values of Pb, Cd and, As were significantly higher in scalp hair samples of smoker and non-smoker diabetic patients as compared to control subjects (p<0.001). The concentration of understudy toxic metals was also high in blood and urine samples of DM patient but difference was more significant in smoker DM patients. These results are consistent with those obtained in other studies, confirming that toxic metals may play a role in the development of diabetes mellitus. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18276029/Evaluation_of_status_of_toxic_metals_in_biological_samples_of_diabetes_mellitus_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00003-X DB - PRIME DP - Unbound Medicine ER -