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Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection.
Nihon Ishinkin Gakkai Zasshi 2008; 49(1):27-31NI

Abstract

BACKGROUND

Infection with the anthropophilic fungus Trichophyton tonsurans has spread among members of combat sports clubs and has become a serious public health problem in Japan and other countries. Infection usually provokes only a weak inflammatory response, and treatment compliance tends to be poor.

OBJECTIVE

To evaluate the hairbrush method and the treatment protocol described in the guidelines for T. tonsurans infection.

METHOD

The study subjects were 69 individuals with positive hairbrush culture from among 327 members of 12 judo clubs participating in the survey. (a) Subjects with no more than 4 colonies by the hairbrush method were treated with miconazole nitrate shampoo. (b) Subjects with 5 or more colonies were treated with (1) itraconazole at a dose of 100 mg/day for 6 weeks or at a dose of 400 mg/day for 1 week, or (2) terbinafine at a dose of 125 mg/day for 6 weeks or at a dose of 500 mg/day for 1 week. Treatment efficacy was monitored by the hairbrush method at 1.5 and 3 months after treatment.

RESULTS

Of the 46 subjects with 5 or more colonies isolated by the hairbrush method, 32 (69.6%) took itraconazole or terbinafine in compliance with their treatment schedules and were negative for T. tonsurans after treatment. Of the 23 subjects with 4 or fewer colonies, 15 (65.2%) were negative for T. tonsurans after treatment with miconazole nitrate shampoo.

CONCLUSION

The treatment protocol seems promising, but poor compliance is a problem with the oral treatment regimens. The shampoo therapy is only partially effective, with 35% of subjects remaining positive for T. tonsurans after this therapy. In order to eradicate this disease, we have renewed the guidelines for T. tonsurans infection.

Authors+Show Affiliations

Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18277048

Citation

Shiraki, Yumi, et al. "Assessment of the Treatment Protocol Described in the Guidelines for Trichophyton Tonsurans Infection." Nihon Ishinkin Gakkai Zasshi = Japanese Journal of Medical Mycology, vol. 49, no. 1, 2008, pp. 27-31.
Shiraki Y, Hiruma M, Sugita T, et al. Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection. Nihon Ishinkin Gakkai Zasshi. 2008;49(1):27-31.
Shiraki, Y., Hiruma, M., Sugita, T., & Ikeda, S. (2008). Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection. Nihon Ishinkin Gakkai Zasshi = Japanese Journal of Medical Mycology, 49(1), pp. 27-31.
Shiraki Y, et al. Assessment of the Treatment Protocol Described in the Guidelines for Trichophyton Tonsurans Infection. Nihon Ishinkin Gakkai Zasshi. 2008;49(1):27-31. PubMed PMID: 18277048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection. AU - Shiraki,Yumi, AU - Hiruma,Masataro, AU - Sugita,Takashi, AU - Ikeda,Shigaku, PY - 2008/2/16/pubmed PY - 2008/5/21/medline PY - 2008/2/16/entrez SP - 27 EP - 31 JF - Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology JO - Nihon Ishinkin Gakkai Zasshi VL - 49 IS - 1 N2 - BACKGROUND: Infection with the anthropophilic fungus Trichophyton tonsurans has spread among members of combat sports clubs and has become a serious public health problem in Japan and other countries. Infection usually provokes only a weak inflammatory response, and treatment compliance tends to be poor. OBJECTIVE: To evaluate the hairbrush method and the treatment protocol described in the guidelines for T. tonsurans infection. METHOD: The study subjects were 69 individuals with positive hairbrush culture from among 327 members of 12 judo clubs participating in the survey. (a) Subjects with no more than 4 colonies by the hairbrush method were treated with miconazole nitrate shampoo. (b) Subjects with 5 or more colonies were treated with (1) itraconazole at a dose of 100 mg/day for 6 weeks or at a dose of 400 mg/day for 1 week, or (2) terbinafine at a dose of 125 mg/day for 6 weeks or at a dose of 500 mg/day for 1 week. Treatment efficacy was monitored by the hairbrush method at 1.5 and 3 months after treatment. RESULTS: Of the 46 subjects with 5 or more colonies isolated by the hairbrush method, 32 (69.6%) took itraconazole or terbinafine in compliance with their treatment schedules and were negative for T. tonsurans after treatment. Of the 23 subjects with 4 or fewer colonies, 15 (65.2%) were negative for T. tonsurans after treatment with miconazole nitrate shampoo. CONCLUSION: The treatment protocol seems promising, but poor compliance is a problem with the oral treatment regimens. The shampoo therapy is only partially effective, with 35% of subjects remaining positive for T. tonsurans after this therapy. In order to eradicate this disease, we have renewed the guidelines for T. tonsurans infection. SN - 0916-4804 UR - https://www.unboundmedicine.com/medline/citation/18277048/Assessment_of_the_treatment_protocol_described_in_the_guidelines_for_Trichophyton_tonsurans_infection_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/jjmm/49.27?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -