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Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry.
Blood Coagul Fibrinolysis 2008; 19(2):159-65BC

Abstract

As arterial and venous thrombosis share common risk factors, a link between arterial and venous thrombosis has been suggested recently. Therefore, we aimed to investigate the impact of established cardiovascular risk factors on the risk of recurrent venous thromboembolism (VTE). With a cross-sectional study design, we analyzed the data of 1006 patients (582 F, 424 M) consecutively treated in our outpatient department for VTE (i.e. lower extremity deep vein thrombosis and/or pulmonary embolism) and registered in the MAISTHRO (MAin-ISar-THROmbosis) database. Of the total cohort, 324 (32.2%) patients suffered a recurrent VTE. Compared with the patients with a single thromboembolic event, patients with recurrent VTE were more frequently male (39.4 vs. 27.0%, P < 0.001). In univariate analysis, the relative risk of recurrent VTE was 1.9 [95% confidence interval (CI) 1.53-2.39] for male sex and 1.6 (1.25-1.95) for age over 50 years (PAOD). After adjustments for age, sex, thrombophilia and other common VTE risk factors, male sex [hazard ratio (HR) = 1.7 (1.38-21.9)] and arterial hypertension [HR = 1.4 (1.05-1.78)] were independent risk factors of recurrent VTE. The higher risk in men than in women persisted even after the exclusion of women with transient hormonal risk factors [HR = 1.57 (1.19-2.07)]. In contrast, no association between the presence of diabetes, obesity, hypercholesterolemia or smoking and the risk of VTE recurrence was observed. Male sex and arterial hypertension are independently associated with an increased risk of recurrent VTE after termination of anticoagulant therapy for the first VTE event.

Authors+Show Affiliations

J.W. Goethe University Hospital, Department of Internal Medicine, Division of Vascular Medicine, Frankfurt/Main, Germany. Birgit.Linnemann@kgu.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18277138

Citation

Linnemann, Birgit, et al. "Impact of Sex and Traditional Cardiovascular Risk Factors On the Risk of Recurrent Venous Thromboembolism: Results From the German MAISTHRO Registry." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 19, no. 2, 2008, pp. 159-65.
Linnemann B, Zgouras D, Schindewolf M, et al. Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry. Blood Coagul Fibrinolysis. 2008;19(2):159-65.
Linnemann, B., Zgouras, D., Schindewolf, M., Schwonberg, J., Jarosch-Preusche, M., & Lindhoff-Last, E. (2008). Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 19(2), pp. 159-65. doi:10.1097/MBC.0b013e3282f54558.
Linnemann B, et al. Impact of Sex and Traditional Cardiovascular Risk Factors On the Risk of Recurrent Venous Thromboembolism: Results From the German MAISTHRO Registry. Blood Coagul Fibrinolysis. 2008;19(2):159-65. PubMed PMID: 18277138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry. AU - Linnemann,Birgit, AU - Zgouras,Dimitrios, AU - Schindewolf,Marc, AU - Schwonberg,Jan, AU - Jarosch-Preusche,Marie, AU - Lindhoff-Last,Edelgard, PY - 2008/2/16/pubmed PY - 2008/5/21/medline PY - 2008/2/16/entrez SP - 159 EP - 65 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 19 IS - 2 N2 - As arterial and venous thrombosis share common risk factors, a link between arterial and venous thrombosis has been suggested recently. Therefore, we aimed to investigate the impact of established cardiovascular risk factors on the risk of recurrent venous thromboembolism (VTE). With a cross-sectional study design, we analyzed the data of 1006 patients (582 F, 424 M) consecutively treated in our outpatient department for VTE (i.e. lower extremity deep vein thrombosis and/or pulmonary embolism) and registered in the MAISTHRO (MAin-ISar-THROmbosis) database. Of the total cohort, 324 (32.2%) patients suffered a recurrent VTE. Compared with the patients with a single thromboembolic event, patients with recurrent VTE were more frequently male (39.4 vs. 27.0%, P < 0.001). In univariate analysis, the relative risk of recurrent VTE was 1.9 [95% confidence interval (CI) 1.53-2.39] for male sex and 1.6 (1.25-1.95) for age over 50 years (PAOD). After adjustments for age, sex, thrombophilia and other common VTE risk factors, male sex [hazard ratio (HR) = 1.7 (1.38-21.9)] and arterial hypertension [HR = 1.4 (1.05-1.78)] were independent risk factors of recurrent VTE. The higher risk in men than in women persisted even after the exclusion of women with transient hormonal risk factors [HR = 1.57 (1.19-2.07)]. In contrast, no association between the presence of diabetes, obesity, hypercholesterolemia or smoking and the risk of VTE recurrence was observed. Male sex and arterial hypertension are independently associated with an increased risk of recurrent VTE after termination of anticoagulant therapy for the first VTE event. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/18277138/Impact_of_sex_and_traditional_cardiovascular_risk_factors_on_the_risk_of_recurrent_venous_thromboembolism:_results_from_the_German_MAISTHRO_Registry_ L2 - http://Insights.ovid.com/pubmed?pmid=18277138 DB - PRIME DP - Unbound Medicine ER -