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Impact of acellular pertussis preschool booster vaccination on disease burden of pertussis in The Netherlands.
Pediatr Infect Dis J. 2008 Mar; 27(3):218-23.PI

Abstract

BACKGROUND

An acellular preschool booster vaccination against pertussis has been included in the National Immunization Programme in The Netherlands, since November 2001. We studied the impact of this preschool booster on the epidemiology of pertussis.

METHODS

We analyzed and compared pertussis cases registered in the national notification system, hospital registry, and death registry between the periods 1998-2001 (without preschool booster) and 2002-2005 (with preschool booster).

RESULTS

In 2002-2005, the incidence of hospitalizations and notifications in 1-4 year olds were 48% and 44%, lower respectively, than in 1998-2001. Similarly, in 5-9 year olds the incidence of hospitalizations and notifications had decreased 32% and 15%, respectively. In 2005, vaccine effectiveness for preschool booster among children born between January 1, 1998 and January 1, 2001--all of whom had been eligible for the booster--was estimated at 79% (95% CI: 71-85). In infants aged 0-6 months, the incidence of hospitalizations per 100,000 population decreased 40%, from 222.5 to 133.6. In contrast, among cohorts aged 10-19, 20-59, and >60 years, the incidence of notifications increased 60%, 44%, and 68%, respectively.

CONCLUSIONS

The preschool booster strongly decreased the disease burden in the targeted cohorts. Importantly, the incidence in infants 0-6 months also showed a decline after introduction of the preschool booster, suggesting reduced transmission from siblings to young infants. Meanwhile, the number of pertussis cases in adolescents and adults increased. With prevention of severe pertussis among infants as focus, this effect should not be ignored in the discussion on future vaccination strategies for pertussis.

Authors+Show Affiliations

Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. sabine.de.greeff@rivm.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18277916

Citation

de Greeff, Sabine C., et al. "Impact of Acellular Pertussis Preschool Booster Vaccination On Disease Burden of Pertussis in the Netherlands." The Pediatric Infectious Disease Journal, vol. 27, no. 3, 2008, pp. 218-23.
de Greeff SC, Mooi FR, Schellekens JF, et al. Impact of acellular pertussis preschool booster vaccination on disease burden of pertussis in The Netherlands. Pediatr Infect Dis J. 2008;27(3):218-23.
de Greeff, S. C., Mooi, F. R., Schellekens, J. F., & de Melker, H. E. (2008). Impact of acellular pertussis preschool booster vaccination on disease burden of pertussis in The Netherlands. The Pediatric Infectious Disease Journal, 27(3), 218-23. https://doi.org/10.1097/INF.0b013e318161a2b9
de Greeff SC, et al. Impact of Acellular Pertussis Preschool Booster Vaccination On Disease Burden of Pertussis in the Netherlands. Pediatr Infect Dis J. 2008;27(3):218-23. PubMed PMID: 18277916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of acellular pertussis preschool booster vaccination on disease burden of pertussis in The Netherlands. AU - de Greeff,Sabine C, AU - Mooi,Frits R, AU - Schellekens,Joop F P, AU - de Melker,Hester E, PY - 2008/2/19/pubmed PY - 2008/6/13/medline PY - 2008/2/19/entrez SP - 218 EP - 23 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 27 IS - 3 N2 - BACKGROUND: An acellular preschool booster vaccination against pertussis has been included in the National Immunization Programme in The Netherlands, since November 2001. We studied the impact of this preschool booster on the epidemiology of pertussis. METHODS: We analyzed and compared pertussis cases registered in the national notification system, hospital registry, and death registry between the periods 1998-2001 (without preschool booster) and 2002-2005 (with preschool booster). RESULTS: In 2002-2005, the incidence of hospitalizations and notifications in 1-4 year olds were 48% and 44%, lower respectively, than in 1998-2001. Similarly, in 5-9 year olds the incidence of hospitalizations and notifications had decreased 32% and 15%, respectively. In 2005, vaccine effectiveness for preschool booster among children born between January 1, 1998 and January 1, 2001--all of whom had been eligible for the booster--was estimated at 79% (95% CI: 71-85). In infants aged 0-6 months, the incidence of hospitalizations per 100,000 population decreased 40%, from 222.5 to 133.6. In contrast, among cohorts aged 10-19, 20-59, and >60 years, the incidence of notifications increased 60%, 44%, and 68%, respectively. CONCLUSIONS: The preschool booster strongly decreased the disease burden in the targeted cohorts. Importantly, the incidence in infants 0-6 months also showed a decline after introduction of the preschool booster, suggesting reduced transmission from siblings to young infants. Meanwhile, the number of pertussis cases in adolescents and adults increased. With prevention of severe pertussis among infants as focus, this effect should not be ignored in the discussion on future vaccination strategies for pertussis. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/18277916/Impact_of_acellular_pertussis_preschool_booster_vaccination_on_disease_burden_of_pertussis_in_The_Netherlands_ L2 - https://doi.org/10.1097/INF.0b013e318161a2b9 DB - PRIME DP - Unbound Medicine ER -