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PAI-1 gene 4G/5G polymorphism, cytokine levels and their relations with metabolic parameters in obese children.
Thromb Haemost. 2008 Feb; 99(2):352-6.TH

Abstract

Obesity is associated with the changes of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNFalpha) and transforming growth factor beta (TGFbeta) levels. However, the precise effect of the 4G allele on obesity is still contradictory. Here, we aimed to elucidate the role of the 4G/5G polymorphism of the PAI-1 gene on the PAI-1 level and determine the associations between cytokines, glucose and lipid metabolism parameters in obese children. Thirty-nine obese children (mean age 11.4 +/- 3.3 years) and 38 age-matched healthy control group (mean age 10.3 +/- 3.5 years) were included in the study. In all cases, serum levels of glucose, lipid and insulin were measured, homeostasis model assessment of insulin resistance (HOMA-IR) was calculated, and 4G/5G polymorphism of PAI-1 gene, plasma PAI-1 level and serum TNFalpha and TGFbeta levels were studied. The mean relative body mass index (BMI) and HOMA-IR score, VLDL, TG, insulin, PAI-1, TNFalpha levels were higher, and HDL and TGFbeta levels were lower in the obese group. The frequency of the 4G/4G genotype was considerably higher in obese children than in controls. Also, a positive correlation was found between PAI-1 and TNFalpha levels, and relative BMI, HOMA-IR score, insulin, TG, HDL levels. TGFbeta was inversely correlated only with relative BMI. There was no correlation among three cytokines. In conclusion, childhood obesity contributes to higher PAI-1 and TNFalpha and lower TGFbeta levels. Especially PAI-1 and TNFalpha accompany insulin resistance and dyslipidemia.

Authors+Show Affiliations

Başkent University Faculty of Medicine, 6. Cadde 70/1, 06490 Bahçelievler, Ankara, Turkey. stkinik@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18278185

Citation

Kinik, Sibel Tulgar, et al. "PAI-1 Gene 4G/5G Polymorphism, Cytokine Levels and Their Relations With Metabolic Parameters in Obese Children." Thrombosis and Haemostasis, vol. 99, no. 2, 2008, pp. 352-6.
Kinik ST, Ozbek N, Yuce M, et al. PAI-1 gene 4G/5G polymorphism, cytokine levels and their relations with metabolic parameters in obese children. Thromb Haemost. 2008;99(2):352-6.
Kinik, S. T., Ozbek, N., Yuce, M., Yazici, A. C., Verdi, H., & Ataç, F. B. (2008). PAI-1 gene 4G/5G polymorphism, cytokine levels and their relations with metabolic parameters in obese children. Thrombosis and Haemostasis, 99(2), 352-6. https://doi.org/10.1160/TH07-06-0395
Kinik ST, et al. PAI-1 Gene 4G/5G Polymorphism, Cytokine Levels and Their Relations With Metabolic Parameters in Obese Children. Thromb Haemost. 2008;99(2):352-6. PubMed PMID: 18278185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PAI-1 gene 4G/5G polymorphism, cytokine levels and their relations with metabolic parameters in obese children. AU - Kinik,Sibel Tulgar, AU - Ozbek,Namik, AU - Yuce,Muammer, AU - Yazici,Ayse Canan, AU - Verdi,Hasibe, AU - Ataç,F Belgin, PY - 2008/2/19/pubmed PY - 2008/4/23/medline PY - 2008/2/19/entrez SP - 352 EP - 6 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 99 IS - 2 N2 - Obesity is associated with the changes of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNFalpha) and transforming growth factor beta (TGFbeta) levels. However, the precise effect of the 4G allele on obesity is still contradictory. Here, we aimed to elucidate the role of the 4G/5G polymorphism of the PAI-1 gene on the PAI-1 level and determine the associations between cytokines, glucose and lipid metabolism parameters in obese children. Thirty-nine obese children (mean age 11.4 +/- 3.3 years) and 38 age-matched healthy control group (mean age 10.3 +/- 3.5 years) were included in the study. In all cases, serum levels of glucose, lipid and insulin were measured, homeostasis model assessment of insulin resistance (HOMA-IR) was calculated, and 4G/5G polymorphism of PAI-1 gene, plasma PAI-1 level and serum TNFalpha and TGFbeta levels were studied. The mean relative body mass index (BMI) and HOMA-IR score, VLDL, TG, insulin, PAI-1, TNFalpha levels were higher, and HDL and TGFbeta levels were lower in the obese group. The frequency of the 4G/4G genotype was considerably higher in obese children than in controls. Also, a positive correlation was found between PAI-1 and TNFalpha levels, and relative BMI, HOMA-IR score, insulin, TG, HDL levels. TGFbeta was inversely correlated only with relative BMI. There was no correlation among three cytokines. In conclusion, childhood obesity contributes to higher PAI-1 and TNFalpha and lower TGFbeta levels. Especially PAI-1 and TNFalpha accompany insulin resistance and dyslipidemia. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/18278185/PAI_1_gene_4G/5G_polymorphism_cytokine_levels_and_their_relations_with_metabolic_parameters_in_obese_children_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH07-06-0395 DB - PRIME DP - Unbound Medicine ER -