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Oral abuse of fentanyl patches (Duragesic): seven case reports.
J Forensic Sci. 2008 Jan; 53(1):222-5.JF

Abstract

In order to increase the understanding regarding the oral abuse and potential toxicity of fentanyl patches seven cases were identified over a 3-year period where fentanyl, either alone or in combination with other factors, contributed to death following the oral abuse of Duragesic patches. The decedents comprised three females and four males with ages ranging from 20 to 51 years. Postmortem blood fentanyl concentrations were determined in all cases and ranged from 7 to 97 ng/mL. Two deaths were classified as a fentanyl overdose, three deaths were classified as a fentanyl and ethanol overdose, one death was considered a mixed drug intoxication and the remaining death was determined to be a combination of fentanyl and medical causes. These cases represent the largest reported series of deaths following the oral administration of transdermal fentanyl patches and provide detailed information on the potential for the abuse of transdermal Duragesic patches via this route. The postmortem blood fentanyl concentrations detected for each of the decedents demonstrate the potentially fatal blood concentrations that can arise after this relatively rare route of administration.

Authors+Show Affiliations

Toxicology Section, Centre of Forensic Sciences, 25 Grosvenor Street, Toronto, ON, Canada M7A 2G8. karen.woodall@ontario.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18279262

Citation

Woodall, Karen L., et al. "Oral Abuse of Fentanyl Patches (Duragesic): Seven Case Reports." Journal of Forensic Sciences, vol. 53, no. 1, 2008, pp. 222-5.
Woodall KL, Martin TL, McLellan BA. Oral abuse of fentanyl patches (Duragesic): seven case reports. J Forensic Sci. 2008;53(1):222-5.
Woodall, K. L., Martin, T. L., & McLellan, B. A. (2008). Oral abuse of fentanyl patches (Duragesic): seven case reports. Journal of Forensic Sciences, 53(1), 222-5. https://doi.org/10.1111/j.1556-4029.2007.00597.x
Woodall KL, Martin TL, McLellan BA. Oral Abuse of Fentanyl Patches (Duragesic): Seven Case Reports. J Forensic Sci. 2008;53(1):222-5. PubMed PMID: 18279262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral abuse of fentanyl patches (Duragesic): seven case reports. AU - Woodall,Karen L, AU - Martin,Teri L, AU - McLellan,Barry A, PY - 2008/2/19/pubmed PY - 2008/5/9/medline PY - 2008/2/19/entrez SP - 222 EP - 5 JF - Journal of forensic sciences JO - J Forensic Sci VL - 53 IS - 1 N2 - In order to increase the understanding regarding the oral abuse and potential toxicity of fentanyl patches seven cases were identified over a 3-year period where fentanyl, either alone or in combination with other factors, contributed to death following the oral abuse of Duragesic patches. The decedents comprised three females and four males with ages ranging from 20 to 51 years. Postmortem blood fentanyl concentrations were determined in all cases and ranged from 7 to 97 ng/mL. Two deaths were classified as a fentanyl overdose, three deaths were classified as a fentanyl and ethanol overdose, one death was considered a mixed drug intoxication and the remaining death was determined to be a combination of fentanyl and medical causes. These cases represent the largest reported series of deaths following the oral administration of transdermal fentanyl patches and provide detailed information on the potential for the abuse of transdermal Duragesic patches via this route. The postmortem blood fentanyl concentrations detected for each of the decedents demonstrate the potentially fatal blood concentrations that can arise after this relatively rare route of administration. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/18279262/Oral_abuse_of_fentanyl_patches__Duragesic_:_seven_case_reports_ L2 - https://doi.org/10.1111/j.1556-4029.2007.00597.x DB - PRIME DP - Unbound Medicine ER -