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Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels.
Diabet Med. 2008 Mar; 25(3):320-5.DM

Abstract

AIMS

To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels.

METHODS

Double-blind, parallel group, placebo-controlled randomized trial. A single dose of 100,000 IU vitamin D2 or placebo was administered to patients with Type 2 diabetes over the winter, when levels of circulating 25-hydroxyvitamin D were likely to be lowest. Patients were enrolled if their baseline 25-hydroxyvitamin D level was < 50 nmol/l. Endothelial function and blood pressure were measured and fasting blood samples were taken at baseline and 8 weeks after administration of vitamin D.

RESULTS

Forty-nine per cent of subjects screened had 25-hydroxyvitamin D levels < 50 nmol/l. Thirty-four subjects completed the study, with a mean age of 64 years and a baseline 25-hydroxyvitamin D level of 38.3 nmol/l. Vitamin D supplementation increased 25-hydroxyvitamin D levels by 15.3 nmol/l relative to placebo and significantly improved flow mediated vasodilatation (FMD) of the brachial artery by 2.3%. The improvement in FMD remained significant after adjusting for changes in blood pressure. Vitamin D supplementation significantly decreased systolic blood pressure by 14 mmHg compared with placebo; this did not correlate with change in FMD.

CONCLUSIONS

Vitamin D insufficiency is common in patients with Type 2 diabetes during winter in Scotland. A single large dose of oral vitamin D2 improves endothelial function in patients with Type 2 diabetes and vitamin D insufficiency.

Authors+Show Affiliations

Department of Clinical Pharmacology, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK. j.a.sugden@dundee.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18279409

Citation

Sugden, J A., et al. "Vitamin D Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus and Low Vitamin D Levels." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 25, no. 3, 2008, pp. 320-5.
Sugden JA, Davies JI, Witham MD, et al. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabet Med. 2008;25(3):320-5.
Sugden, J. A., Davies, J. I., Witham, M. D., Morris, A. D., & Struthers, A. D. (2008). Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabetic Medicine : a Journal of the British Diabetic Association, 25(3), 320-5. https://doi.org/10.1111/j.1464-5491.2007.02360.x
Sugden JA, et al. Vitamin D Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus and Low Vitamin D Levels. Diabet Med. 2008;25(3):320-5. PubMed PMID: 18279409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. AU - Sugden,J A, AU - Davies,J I, AU - Witham,M D, AU - Morris,A D, AU - Struthers,A D, Y1 - 2008/02/13/ PY - 2008/2/19/pubmed PY - 2008/6/26/medline PY - 2008/2/19/entrez SP - 320 EP - 5 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 25 IS - 3 N2 - AIMS: To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels. METHODS: Double-blind, parallel group, placebo-controlled randomized trial. A single dose of 100,000 IU vitamin D2 or placebo was administered to patients with Type 2 diabetes over the winter, when levels of circulating 25-hydroxyvitamin D were likely to be lowest. Patients were enrolled if their baseline 25-hydroxyvitamin D level was < 50 nmol/l. Endothelial function and blood pressure were measured and fasting blood samples were taken at baseline and 8 weeks after administration of vitamin D. RESULTS: Forty-nine per cent of subjects screened had 25-hydroxyvitamin D levels < 50 nmol/l. Thirty-four subjects completed the study, with a mean age of 64 years and a baseline 25-hydroxyvitamin D level of 38.3 nmol/l. Vitamin D supplementation increased 25-hydroxyvitamin D levels by 15.3 nmol/l relative to placebo and significantly improved flow mediated vasodilatation (FMD) of the brachial artery by 2.3%. The improvement in FMD remained significant after adjusting for changes in blood pressure. Vitamin D supplementation significantly decreased systolic blood pressure by 14 mmHg compared with placebo; this did not correlate with change in FMD. CONCLUSIONS: Vitamin D insufficiency is common in patients with Type 2 diabetes during winter in Scotland. A single large dose of oral vitamin D2 improves endothelial function in patients with Type 2 diabetes and vitamin D insufficiency. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/18279409/Vitamin_D_improves_endothelial_function_in_patients_with_Type_2_diabetes_mellitus_and_low_vitamin_D_levels_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02360.x DB - PRIME DP - Unbound Medicine ER -