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Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.
Toxicology. 2008 Apr 03; 246(1):55-62.T

Abstract

Ciguatera is a common illness in tropical and subtropical regions that manifests in complex and long-lived symptoms which are more severe in subsequent exposures. This study measures central and peripheral neurologic signs, in parallel with blood toxin levels, in mice exposed once or twice (at 3 days interval) to a sublethal dose of ciguatoxin P-CTX-1 (0.26ng/g via i.p.). Mice were implanted with radiotransmitters to monitor motor activity and core temperature. A single exposure to ciguatoxin elicited an immediate and transient decrease in motor activity and temperature, and subsequent long-lasting thermoregulatory dysfunction resulting in stabilized body temperature around 36.0 degrees C with no observable circadian rhythm. The hypothermic response and the reduced activity were enhanced with a second exposure with 30% of the mice dying within 7h. Measurement of the peripheral nervous system by the tail flick assay revealed increased latency with a single ciguatoxin exposure, and a greater effect following the second exposure. Toxin was measurable in blood up to 3 days following the first exposure; at the 1h time point the concentrations were significantly elevated after a second exposure. These findings indicate an early response to ciguatoxin manifest in a central response to lower body temperature and reduce motor activity and a more persistent effect on the peripheral system leading to spinal heat antinociception and delayed fever-like response. The greater neurological response to a second ciguatoxin exposure was associated with elevated concentrations of ciguatoxin in the blood solely over the first hour of exposure. In conclusion, a single exposure to toxin exerts a significant neurological response which may be enhanced with subsequent exposure.

Authors+Show Affiliations

Center for Coastal Environmental Health and Biomolecular Research, NOAA-National Ocean Service, Charleston, SC 29412, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18280027

Citation

Bottein Dechraoui, Marie-Yasmine, et al. "Repeat Exposure to Ciguatoxin Leads to Enhanced and Sustained Thermoregulatory, Pain Threshold and Motor Activity Responses in Mice: Relationship to Blood Ciguatoxin Concentrations." Toxicology, vol. 246, no. 1, 2008, pp. 55-62.
Bottein Dechraoui MY, Rezvani AH, Gordon CJ, et al. Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations. Toxicology. 2008;246(1):55-62.
Bottein Dechraoui, M. Y., Rezvani, A. H., Gordon, C. J., Levin, E. D., & Ramsdell, J. S. (2008). Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations. Toxicology, 246(1), 55-62. https://doi.org/10.1016/j.tox.2007.12.013
Bottein Dechraoui MY, et al. Repeat Exposure to Ciguatoxin Leads to Enhanced and Sustained Thermoregulatory, Pain Threshold and Motor Activity Responses in Mice: Relationship to Blood Ciguatoxin Concentrations. Toxicology. 2008 Apr 3;246(1):55-62. PubMed PMID: 18280027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations. AU - Bottein Dechraoui,Marie-Yasmine, AU - Rezvani,Amir H, AU - Gordon,Christopher J, AU - Levin,Edward D, AU - Ramsdell,John S, Y1 - 2007/12/27/ PY - 2007/08/17/received PY - 2007/12/13/revised PY - 2007/12/17/accepted PY - 2008/2/19/pubmed PY - 2008/5/9/medline PY - 2008/2/19/entrez SP - 55 EP - 62 JF - Toxicology JO - Toxicology VL - 246 IS - 1 N2 - Ciguatera is a common illness in tropical and subtropical regions that manifests in complex and long-lived symptoms which are more severe in subsequent exposures. This study measures central and peripheral neurologic signs, in parallel with blood toxin levels, in mice exposed once or twice (at 3 days interval) to a sublethal dose of ciguatoxin P-CTX-1 (0.26ng/g via i.p.). Mice were implanted with radiotransmitters to monitor motor activity and core temperature. A single exposure to ciguatoxin elicited an immediate and transient decrease in motor activity and temperature, and subsequent long-lasting thermoregulatory dysfunction resulting in stabilized body temperature around 36.0 degrees C with no observable circadian rhythm. The hypothermic response and the reduced activity were enhanced with a second exposure with 30% of the mice dying within 7h. Measurement of the peripheral nervous system by the tail flick assay revealed increased latency with a single ciguatoxin exposure, and a greater effect following the second exposure. Toxin was measurable in blood up to 3 days following the first exposure; at the 1h time point the concentrations were significantly elevated after a second exposure. These findings indicate an early response to ciguatoxin manifest in a central response to lower body temperature and reduce motor activity and a more persistent effect on the peripheral system leading to spinal heat antinociception and delayed fever-like response. The greater neurological response to a second ciguatoxin exposure was associated with elevated concentrations of ciguatoxin in the blood solely over the first hour of exposure. In conclusion, a single exposure to toxin exerts a significant neurological response which may be enhanced with subsequent exposure. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/18280027/Repeat_exposure_to_ciguatoxin_leads_to_enhanced_and_sustained_thermoregulatory_pain_threshold_and_motor_activity_responses_in_mice:_relationship_to_blood_ciguatoxin_concentrations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(07)00849-9 DB - PRIME DP - Unbound Medicine ER -