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Histamine-induced modulation of vascular tone in the isolated chicken basilar artery: a possible involvement of endothelium.
Comp Biochem Physiol C Toxicol Pharmacol. 2008 Apr; 147(3):339-44.CB

Abstract

We investigated the histamine responsiveness of basilar arterial rings isolated from chicken. We also examined whether endothelial cells were involved in the histamine responsiveness and in resting vascular tone. Histamine induced concentration-dependent relaxations under condition of precontraction by 5-hydroxytryptamine. The concentration-response curve for histamine was shifted to the right by diphenhydramine (a H(1) receptor antagonist), cimetidine (a H(2) receptor antagonist) and Nomega-nitro-L-arginine (L-NNA, a nitric oxide synthase inhibitor); however, indomethacin (a cyclooxygenase inhibitor) had no significant effect on it. Treatment with L-NNA shifted the concentration-response curve of histamine to the right in the presence of cimetidine, but not in the presence of diphenhydramine. Treatment with cimetidine shifted the concentration-response curve of histamine to the right in the presence of diphenhydramine. L-NNA induced a contraction but indomethacin had no effect on the resting vascular tone. These results suggest that histamine-induced relaxation is mediated via activation of H(1) receptors located on endothelial cells and H(2) receptors located on smooth muscle cells. The main relaxing factor released from endothelial cells is probably nitric oxide. The resting vascular tone was modulated by spontaneously released nitric oxide, but not by prostaglandins or thromboxane A(2).

Authors+Show Affiliations

Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18280220

Citation

Okuno, Tadatsune, et al. "Histamine-induced Modulation of Vascular Tone in the Isolated Chicken Basilar Artery: a Possible Involvement of Endothelium." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 147, no. 3, 2008, pp. 339-44.
Okuno T, Yabuki A, Shiraishi M, et al. Histamine-induced modulation of vascular tone in the isolated chicken basilar artery: a possible involvement of endothelium. Comp Biochem Physiol C Toxicol Pharmacol. 2008;147(3):339-44.
Okuno, T., Yabuki, A., Shiraishi, M., Obi, T., & Miyamoto, A. (2008). Histamine-induced modulation of vascular tone in the isolated chicken basilar artery: a possible involvement of endothelium. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 147(3), 339-44. https://doi.org/10.1016/j.cbpc.2007.12.002
Okuno T, et al. Histamine-induced Modulation of Vascular Tone in the Isolated Chicken Basilar Artery: a Possible Involvement of Endothelium. Comp Biochem Physiol C Toxicol Pharmacol. 2008;147(3):339-44. PubMed PMID: 18280220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine-induced modulation of vascular tone in the isolated chicken basilar artery: a possible involvement of endothelium. AU - Okuno,Tadatsune, AU - Yabuki,Akira, AU - Shiraishi,Mitsuya, AU - Obi,Takeshi, AU - Miyamoto,Atsushi, Y1 - 2008/01/11/ PY - 2007/10/15/received PY - 2007/12/20/revised PY - 2007/12/20/accepted PY - 2008/2/19/pubmed PY - 2008/5/30/medline PY - 2008/2/19/entrez SP - 339 EP - 44 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 147 IS - 3 N2 - We investigated the histamine responsiveness of basilar arterial rings isolated from chicken. We also examined whether endothelial cells were involved in the histamine responsiveness and in resting vascular tone. Histamine induced concentration-dependent relaxations under condition of precontraction by 5-hydroxytryptamine. The concentration-response curve for histamine was shifted to the right by diphenhydramine (a H(1) receptor antagonist), cimetidine (a H(2) receptor antagonist) and Nomega-nitro-L-arginine (L-NNA, a nitric oxide synthase inhibitor); however, indomethacin (a cyclooxygenase inhibitor) had no significant effect on it. Treatment with L-NNA shifted the concentration-response curve of histamine to the right in the presence of cimetidine, but not in the presence of diphenhydramine. Treatment with cimetidine shifted the concentration-response curve of histamine to the right in the presence of diphenhydramine. L-NNA induced a contraction but indomethacin had no effect on the resting vascular tone. These results suggest that histamine-induced relaxation is mediated via activation of H(1) receptors located on endothelial cells and H(2) receptors located on smooth muscle cells. The main relaxing factor released from endothelial cells is probably nitric oxide. The resting vascular tone was modulated by spontaneously released nitric oxide, but not by prostaglandins or thromboxane A(2). SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/18280220/Histamine_induced_modulation_of_vascular_tone_in_the_isolated_chicken_basilar_artery:_a_possible_involvement_of_endothelium_ DB - PRIME DP - Unbound Medicine ER -