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Compaction behavior of roller compacted ibuprofen.
Eur J Pharm Biopharm. 2008 Jun; 69(2):743-9.EJ

Abstract

The effect of roller compaction pressure on the bulk compaction of roller compacted ibuprofen was investigated using instrumented rotary tablet press. Three different roller pressures were utilized to prepare granules and Heckel analysis, Walker analysis, compressibility, and tabletability were performed to derive densification, deformation, course of volume reduction and bonding phenomenon of different pressure roller compacted granules. Nominal single granule fracture strength was obtained by micro tensile testing. Heckel analysis indicated that granules prepared using lower pressure during roller compaction showed lower yield strength. The reduction in tabletability was observed for higher pressure roller compacted granules. The reduction in tabletability supports the results of granule size enlargement theory. Apart from the granule size enlargement theory, the available fines and relative fragmentation during compaction is responsible for higher bonding strength and provide larger areas for true particle contact at constant porosity for lower pressure roller compacted granules. Overall bulk compaction parameters indicated that granules prepared by lower roller compaction pressure were advantageous in terms of tabletability and densification. Overall results suggested that densification during roller compaction affects the particle level properties of specific surface area, nominal fracture strength, and compaction behavior.

Authors+Show Affiliations

Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research, SAS. Nagar, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18280716

Citation

Patel, Sarsvatkumar, et al. "Compaction Behavior of Roller Compacted Ibuprofen." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 69, no. 2, 2008, pp. 743-9.
Patel S, Kaushal AM, Bansal AK. Compaction behavior of roller compacted ibuprofen. Eur J Pharm Biopharm. 2008;69(2):743-9.
Patel, S., Kaushal, A. M., & Bansal, A. K. (2008). Compaction behavior of roller compacted ibuprofen. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 69(2), 743-9. https://doi.org/10.1016/j.ejpb.2008.01.005
Patel S, Kaushal AM, Bansal AK. Compaction Behavior of Roller Compacted Ibuprofen. Eur J Pharm Biopharm. 2008;69(2):743-9. PubMed PMID: 18280716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compaction behavior of roller compacted ibuprofen. AU - Patel,Sarsvatkumar, AU - Kaushal,Aditya Mohan, AU - Bansal,Arvind Kumar, Y1 - 2008/01/16/ PY - 2007/07/14/received PY - 2007/12/23/revised PY - 2008/01/08/accepted PY - 2008/2/19/pubmed PY - 2008/8/30/medline PY - 2008/2/19/entrez SP - 743 EP - 9 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 69 IS - 2 N2 - The effect of roller compaction pressure on the bulk compaction of roller compacted ibuprofen was investigated using instrumented rotary tablet press. Three different roller pressures were utilized to prepare granules and Heckel analysis, Walker analysis, compressibility, and tabletability were performed to derive densification, deformation, course of volume reduction and bonding phenomenon of different pressure roller compacted granules. Nominal single granule fracture strength was obtained by micro tensile testing. Heckel analysis indicated that granules prepared using lower pressure during roller compaction showed lower yield strength. The reduction in tabletability was observed for higher pressure roller compacted granules. The reduction in tabletability supports the results of granule size enlargement theory. Apart from the granule size enlargement theory, the available fines and relative fragmentation during compaction is responsible for higher bonding strength and provide larger areas for true particle contact at constant porosity for lower pressure roller compacted granules. Overall bulk compaction parameters indicated that granules prepared by lower roller compaction pressure were advantageous in terms of tabletability and densification. Overall results suggested that densification during roller compaction affects the particle level properties of specific surface area, nominal fracture strength, and compaction behavior. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/18280716/Compaction_behavior_of_roller_compacted_ibuprofen_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(08)00014-3 DB - PRIME DP - Unbound Medicine ER -