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Alanine aminotransferase and high sensitivity C-reactive protein: correlates of cardiovascular risk factors in youth.
J Pediatr. 2008 Mar; 152(3):337-42.JPed

Abstract

OBJECTIVE

The association between high-sensitivity C-reactive protein (hs-CRP) and alanine aminotransferase (ALT) with clinical/metabolic variables was evaluated in overweight Brazilian children and adolescents.

STUDY DESIGN

Oral glucose tolerance test was performed in 407 students (273 overweight/obese, 11.3 +/- 3.1 y). Measurements included body mass index (BMI), waist circumference (WC), blood pressure, lipids, insulin, hs-CRP, and ALT. Overweight/obese was defined using BMI z-score; insulin resistance (IR) by homeostatic model assessment: insulin resistance (HOMA-IR); and metabolic syndrome (MS) in accordance with the modified NCEP-ATPIII.

RESULTS

As weight increased, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), insulin, HOMA-IR, hs-CRP, ALT, ALT, hs-CRP, and AST and the number of MS components (nMSc) also increased (P </= .001 for all). Subjects with hs-CRP and ALT above the median had higher BMI z-score, WC, SBP, DBP, TG, AST, insulin, HOMA-IR, and nMSc than those with both markers below the median (P </= .002 for all). After adjustment for age, sex and ethnicity, BMI z-score (OR, 1.5; CI, 1.38 to 1.86; P < .001), WC (OR,1.3; CI, 1.19 to 1.43; P < .001) SBP (OR, 1.2; CI, 1.03 to 1.38; P = .015), DBP (OR, 1.4; CI, 1.15 to 1.69; P < .001), TG (OR, 1.8; CI, 1.29 to 2.62; P < .001), insulin (OR, 1.4; CI, 1.23 to 1.71; P < .001), HOMA-IR (OR, 1.2; CI, 1.09 to 1.29; P < .001) and nMSc (OR, 2; CI, 1.16 to 3.47; P = .012) were independently associated with high ALT and hs-CRP. For every 5-cm increase in WC and every 1-point increase in BMI z-score, there were a 1.3- and 1.5-fold greater chance of having increased ALT and hs-CRP, respectively.

CONCLUSIONS

Simultaneous measurements of ALT and hs-CRP should be considered as a screening test for metabolic syndrome and cardiovascular disease risk factors in overweight/obese children/adolescents.

Authors+Show Affiliations

Bahian School of Medicine and Public Health, Science Development Foundation of Bahia, Bahia, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18280837

Citation

Oliveira, Antônio C., et al. "Alanine Aminotransferase and High Sensitivity C-reactive Protein: Correlates of Cardiovascular Risk Factors in Youth." The Journal of Pediatrics, vol. 152, no. 3, 2008, pp. 337-42.
Oliveira AC, Oliveira AM, Almeida MS, et al. Alanine aminotransferase and high sensitivity C-reactive protein: correlates of cardiovascular risk factors in youth. J Pediatr. 2008;152(3):337-42.
Oliveira, A. C., Oliveira, A. M., Almeida, M. S., Silva, A. M., Adan, L., & Ladeia, A. M. (2008). Alanine aminotransferase and high sensitivity C-reactive protein: correlates of cardiovascular risk factors in youth. The Journal of Pediatrics, 152(3), 337-42. https://doi.org/10.1016/j.jpeds.2007.07.013
Oliveira AC, et al. Alanine Aminotransferase and High Sensitivity C-reactive Protein: Correlates of Cardiovascular Risk Factors in Youth. J Pediatr. 2008;152(3):337-42. PubMed PMID: 18280837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alanine aminotransferase and high sensitivity C-reactive protein: correlates of cardiovascular risk factors in youth. AU - Oliveira,Antônio C, AU - Oliveira,Ana M, AU - Almeida,Marcele S, AU - Silva,Agnaluce M, AU - Adan,Luis, AU - Ladeia,Ana M, Y1 - 2007/10/22/ PY - 2007/03/19/received PY - 2007/05/29/revised PY - 2007/07/06/accepted PY - 2008/2/19/pubmed PY - 2008/3/19/medline PY - 2008/2/19/entrez SP - 337 EP - 42 JF - The Journal of pediatrics JO - J Pediatr VL - 152 IS - 3 N2 - OBJECTIVE: The association between high-sensitivity C-reactive protein (hs-CRP) and alanine aminotransferase (ALT) with clinical/metabolic variables was evaluated in overweight Brazilian children and adolescents. STUDY DESIGN: Oral glucose tolerance test was performed in 407 students (273 overweight/obese, 11.3 +/- 3.1 y). Measurements included body mass index (BMI), waist circumference (WC), blood pressure, lipids, insulin, hs-CRP, and ALT. Overweight/obese was defined using BMI z-score; insulin resistance (IR) by homeostatic model assessment: insulin resistance (HOMA-IR); and metabolic syndrome (MS) in accordance with the modified NCEP-ATPIII. RESULTS: As weight increased, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), insulin, HOMA-IR, hs-CRP, ALT, ALT, hs-CRP, and AST and the number of MS components (nMSc) also increased (P </= .001 for all). Subjects with hs-CRP and ALT above the median had higher BMI z-score, WC, SBP, DBP, TG, AST, insulin, HOMA-IR, and nMSc than those with both markers below the median (P </= .002 for all). After adjustment for age, sex and ethnicity, BMI z-score (OR, 1.5; CI, 1.38 to 1.86; P < .001), WC (OR,1.3; CI, 1.19 to 1.43; P < .001) SBP (OR, 1.2; CI, 1.03 to 1.38; P = .015), DBP (OR, 1.4; CI, 1.15 to 1.69; P < .001), TG (OR, 1.8; CI, 1.29 to 2.62; P < .001), insulin (OR, 1.4; CI, 1.23 to 1.71; P < .001), HOMA-IR (OR, 1.2; CI, 1.09 to 1.29; P < .001) and nMSc (OR, 2; CI, 1.16 to 3.47; P = .012) were independently associated with high ALT and hs-CRP. For every 5-cm increase in WC and every 1-point increase in BMI z-score, there were a 1.3- and 1.5-fold greater chance of having increased ALT and hs-CRP, respectively. CONCLUSIONS: Simultaneous measurements of ALT and hs-CRP should be considered as a screening test for metabolic syndrome and cardiovascular disease risk factors in overweight/obese children/adolescents. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/18280837/Alanine_aminotransferase_and_high_sensitivity_C_reactive_protein:_correlates_of_cardiovascular_risk_factors_in_youth_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(07)00665-8 DB - PRIME DP - Unbound Medicine ER -