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Cerebral ischemic preconditioning induces lasting effects on CA1 neuronal survival, prevents memory impairments but not ischemia-induced hyperactivity.
Behav Brain Res 2008; 189(1):145-51BB

Abstract

In ischemic preconditioning, prior exposure to a short 3-min global ischemia provides substantial protection against the deleterious effects of a subsequent prolonged ischemic insult in rats. The objective of the present study was to determine if the neuronal protection induced by ischemic preconditioning influence functional recovery following a 6-min ischemic insult in rats. Animals received either sham-operation, a 3-min ischemia, a preconditioning 3-min global ischemia followed 3 days later by a 6-min global ischemia or a single 6-min global ischemia. Open field habituation, memory performance in the 8-arm radial maze and object recognition were assessed at different intervals following ischemia. Our findings revealed that preconditioning reversed ischemia-induced spatial memory deficits in the 8-arm radial maze, as suggested by significant reduction of working memory errors in preconditioned as compared to ischemic animals. Preconditioning also attenuated ischemia-induced object recognition deficits at short-term intervals. Nonetheless, preconditioning failed to alter ischemia-induced hyperactivity as demonstrated by enhanced behavioral activity in the open field in both preconditioned and ischemic animals compared to 3-min ischemic and sham-operated rats. CA1 cell counts revealed significant neuronal sparing in preconditioned animals that was observed 6-month following reperfusion. Together, these findings suggest that neuronal survival in preconditioned rats is associated with significant improvements of hippocampal-dependent memory functions and, further support that ischemia-induced hyperactivity may not solely depend on selective neuronal damage to hippocampal neurons.

Authors+Show Affiliations

University of Ottawa, School of Psychology, 11 Marie Curie, Ottawa, Ontario, Canada K1N 9A9. Hplamond@uottawa.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18281106

Citation

Plamondon, Hélène, et al. "Cerebral Ischemic Preconditioning Induces Lasting Effects On CA1 Neuronal Survival, Prevents Memory Impairments but Not Ischemia-induced Hyperactivity." Behavioural Brain Research, vol. 189, no. 1, 2008, pp. 145-51.
Plamondon H, Davignon G, Khan S, et al. Cerebral ischemic preconditioning induces lasting effects on CA1 neuronal survival, prevents memory impairments but not ischemia-induced hyperactivity. Behav Brain Res. 2008;189(1):145-51.
Plamondon, H., Davignon, G., Khan, S., & Charron, C. (2008). Cerebral ischemic preconditioning induces lasting effects on CA1 neuronal survival, prevents memory impairments but not ischemia-induced hyperactivity. Behavioural Brain Research, 189(1), pp. 145-51. doi:10.1016/j.bbr.2007.12.027.
Plamondon H, et al. Cerebral Ischemic Preconditioning Induces Lasting Effects On CA1 Neuronal Survival, Prevents Memory Impairments but Not Ischemia-induced Hyperactivity. Behav Brain Res. 2008 May 16;189(1):145-51. PubMed PMID: 18281106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral ischemic preconditioning induces lasting effects on CA1 neuronal survival, prevents memory impairments but not ischemia-induced hyperactivity. AU - Plamondon,Hélène, AU - Davignon,Geneviève, AU - Khan,Samir, AU - Charron,Charlaine, Y1 - 2008/01/08/ PY - 2007/10/30/received PY - 2007/12/20/revised PY - 2007/12/26/accepted PY - 2008/2/19/pubmed PY - 2008/7/2/medline PY - 2008/2/19/entrez SP - 145 EP - 51 JF - Behavioural brain research JO - Behav. Brain Res. VL - 189 IS - 1 N2 - In ischemic preconditioning, prior exposure to a short 3-min global ischemia provides substantial protection against the deleterious effects of a subsequent prolonged ischemic insult in rats. The objective of the present study was to determine if the neuronal protection induced by ischemic preconditioning influence functional recovery following a 6-min ischemic insult in rats. Animals received either sham-operation, a 3-min ischemia, a preconditioning 3-min global ischemia followed 3 days later by a 6-min global ischemia or a single 6-min global ischemia. Open field habituation, memory performance in the 8-arm radial maze and object recognition were assessed at different intervals following ischemia. Our findings revealed that preconditioning reversed ischemia-induced spatial memory deficits in the 8-arm radial maze, as suggested by significant reduction of working memory errors in preconditioned as compared to ischemic animals. Preconditioning also attenuated ischemia-induced object recognition deficits at short-term intervals. Nonetheless, preconditioning failed to alter ischemia-induced hyperactivity as demonstrated by enhanced behavioral activity in the open field in both preconditioned and ischemic animals compared to 3-min ischemic and sham-operated rats. CA1 cell counts revealed significant neuronal sparing in preconditioned animals that was observed 6-month following reperfusion. Together, these findings suggest that neuronal survival in preconditioned rats is associated with significant improvements of hippocampal-dependent memory functions and, further support that ischemia-induced hyperactivity may not solely depend on selective neuronal damage to hippocampal neurons. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/18281106/Cerebral_ischemic_preconditioning_induces_lasting_effects_on_CA1_neuronal_survival_prevents_memory_impairments_but_not_ischemia_induced_hyperactivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(08)00009-0 DB - PRIME DP - Unbound Medicine ER -