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N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention.
Int J Cardiol 2009; 133(2):173-8IJ

Abstract

BACKGROUND

Increased level of N-terminal pro-B type natriuretic peptide (NT-proBNP) is known to be associated with adverse outcome in patients with acute coronary syndrome. We evaluated early outcomes of patients with acute ST-elevated myocardial infarction (STEMI) according to the level of NT-proBNP as a substudy of Korean Acute Myocardial Infarction Registry (KAMIR).

METHODS

Study population consisted of 1052 consecutive patients (mean 61.3+/-12.8 years old, male 73.2%) with STEMI of onset <12 h who underwent primary percutaneous coronary intervention (PCI) and who had baseline NT-proBNP level by electrochemiluminescence immnunoassay (ECLIA, NT-proBNP kit, Roche Diagnostics, Mannheim, Germany). The study subjects were divided into two groups according to the level of serum NT-proBNP.

RESULTS

Patients with NT-proBNP level >991 pg/mL (n=329, 57.1% male) had lower left ventricle ejection fraction (LVEF) (47.8+/-11.8% vs. 53.0+/-10.8%, p<0.001), needed longer intensive care (3.7+/-3.6 days vs. 2.8+/-2.4 days, p<0.001) and had higher in-hospital mortality (1.3% vs. 7.4%, p<0.001) than those with NT-proBNP level<or=991 pg/mL (n=723, 80.5% male). Multiple logistic regression analysis revealed that the independent predictors of in-hospital mortality were LVEF<45% (OR 5.43, 95% CI 1.71 to 17.29, p=0.004), elevated NT-proBNP (>991 pg/mL) (OR 3.70, 95% CI 1.14 to 12.03, p=0.030), old age (>or=70 years) (OR 4.71, 95% CI 1.43 to 15.52, p=0.011), advanced Killip class (>1) (OR 4.96, 95% CI 1.58 to 15.53, p=0.006), male gender (OR 5.67, 95% CI 1.45 to 22.21, p=0.013) and TIMI flow 0 before PCI (OR 5.04, 95% CI 1.08 to 23.41, p=0.039).

CONCLUSIONS

This study suggests that baseline NT-proBNP level is associated with short term mortality in patients with STEMI underwent primary PCI.

Authors+Show Affiliations

Cardiology, Heart Center, Konyang University Hospital, Deajeon, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18281115

Citation

Kwon, Taek Geun, et al. "N-terminal pro-B-type Natriuretic Peptide Is Associated With Adverse Short-term Clinical Outcomes in Patients With Acute ST-elevation Myocardial Infarction Underwent Primary Percutaneous Coronary Intervention." International Journal of Cardiology, vol. 133, no. 2, 2009, pp. 173-8.
Kwon TG, Bae JH, Jeong MH, et al. N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention. Int J Cardiol. 2009;133(2):173-8.
Kwon, T. G., Bae, J. H., Jeong, M. H., Kim, Y. J., Hur, S. H., Seong, I. W., ... Park, S. J. (2009). N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention. International Journal of Cardiology, 133(2), pp. 173-8. doi:10.1016/j.ijcard.2007.12.022.
Kwon TG, et al. N-terminal pro-B-type Natriuretic Peptide Is Associated With Adverse Short-term Clinical Outcomes in Patients With Acute ST-elevation Myocardial Infarction Underwent Primary Percutaneous Coronary Intervention. Int J Cardiol. 2009 Apr 3;133(2):173-8. PubMed PMID: 18281115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention. AU - Kwon,Taek Geun, AU - Bae,Jang Ho, AU - Jeong,Myung Ho, AU - Kim,Young Jo, AU - Hur,Seung Ho, AU - Seong,In Whan, AU - Cho,Myeong Chan, AU - Seung,Ki Bae, AU - Jang,Yang Soo, AU - Park,Seung Jung, AU - ,, Y1 - 2008/02/20/ PY - 2007/05/08/received PY - 2007/08/27/revised PY - 2007/12/11/accepted PY - 2008/2/19/pubmed PY - 2009/7/25/medline PY - 2008/2/19/entrez SP - 173 EP - 8 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 133 IS - 2 N2 - BACKGROUND: Increased level of N-terminal pro-B type natriuretic peptide (NT-proBNP) is known to be associated with adverse outcome in patients with acute coronary syndrome. We evaluated early outcomes of patients with acute ST-elevated myocardial infarction (STEMI) according to the level of NT-proBNP as a substudy of Korean Acute Myocardial Infarction Registry (KAMIR). METHODS: Study population consisted of 1052 consecutive patients (mean 61.3+/-12.8 years old, male 73.2%) with STEMI of onset <12 h who underwent primary percutaneous coronary intervention (PCI) and who had baseline NT-proBNP level by electrochemiluminescence immnunoassay (ECLIA, NT-proBNP kit, Roche Diagnostics, Mannheim, Germany). The study subjects were divided into two groups according to the level of serum NT-proBNP. RESULTS: Patients with NT-proBNP level >991 pg/mL (n=329, 57.1% male) had lower left ventricle ejection fraction (LVEF) (47.8+/-11.8% vs. 53.0+/-10.8%, p<0.001), needed longer intensive care (3.7+/-3.6 days vs. 2.8+/-2.4 days, p<0.001) and had higher in-hospital mortality (1.3% vs. 7.4%, p<0.001) than those with NT-proBNP level<or=991 pg/mL (n=723, 80.5% male). Multiple logistic regression analysis revealed that the independent predictors of in-hospital mortality were LVEF<45% (OR 5.43, 95% CI 1.71 to 17.29, p=0.004), elevated NT-proBNP (>991 pg/mL) (OR 3.70, 95% CI 1.14 to 12.03, p=0.030), old age (>or=70 years) (OR 4.71, 95% CI 1.43 to 15.52, p=0.011), advanced Killip class (>1) (OR 4.96, 95% CI 1.58 to 15.53, p=0.006), male gender (OR 5.67, 95% CI 1.45 to 22.21, p=0.013) and TIMI flow 0 before PCI (OR 5.04, 95% CI 1.08 to 23.41, p=0.039). CONCLUSIONS: This study suggests that baseline NT-proBNP level is associated with short term mortality in patients with STEMI underwent primary PCI. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/18281115/N_terminal_pro_B_type_natriuretic_peptide_is_associated_with_adverse_short_term_clinical_outcomes_in_patients_with_acute_ST_elevation_myocardial_infarction_underwent_primary_percutaneous_coronary_intervention_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(08)00003-X DB - PRIME DP - Unbound Medicine ER -