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The activation of histamine-sensitive sites of the ventral hippocampus modulates the consolidation of a learned active avoidance response in rats.
Behav Brain Res. 2008 May 16; 189(1):92-9.BB

Abstract

Previous evidence from our laboratory has shown that histamine receptors located into the ventral hippocampus modulate learning and memory processes. Stimulation of histamine hippocampal sensitive receptors during the acquisition phase of a conditioned avoidance response to an ultrasonic tone was able to increase latency to escape and impair memory in the rat. Histamine application into the same hippocampal region also impaired the evocation of the response. The purpose of the present work was to evaluate if histaminergic neuron circuits have participation on the consolidation processes of the conditioned avoiding response. Male adult rats were implanted into the ventral hippocampus with microinjection cannulae and subjected consecutively to 2 sessions of 8 trials to learn an avoidance response after an ultrasonic tone of 40 kHz was on, as it was previously described. Immediately after the training period was over, or 15 min after, different groups of rats were microinjected with saline, histamine or a combination of histamine H(1)- or H(2)-receptor antagonists. Twenty four hours later, animals were tested in a new session for the retention of the avoiding response. Results showed that histamine treatment interfered with the consolidation of the avoiding response, affecting latency and the memory efficiency. This interference was mediated by histamine H(1)- and H(2)-receptors, since pretreatment with pyrilamine or ranitidine blocked the inhibitory effect of histamine. Results support the concept that histaminergic neurotransmission modulates learning and memory by affecting selectively the three stages of learning.

Authors+Show Affiliations

Area de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, and IMBECU, CONICET, Mendoza, Argentina. ealvarez@fcm.uncu.edu.arNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18282618

Citation

Alvarez, Edgardo O., and Arturo M. Banzan. "The Activation of Histamine-sensitive Sites of the Ventral Hippocampus Modulates the Consolidation of a Learned Active Avoidance Response in Rats." Behavioural Brain Research, vol. 189, no. 1, 2008, pp. 92-9.
Alvarez EO, Banzan AM. The activation of histamine-sensitive sites of the ventral hippocampus modulates the consolidation of a learned active avoidance response in rats. Behav Brain Res. 2008;189(1):92-9.
Alvarez, E. O., & Banzan, A. M. (2008). The activation of histamine-sensitive sites of the ventral hippocampus modulates the consolidation of a learned active avoidance response in rats. Behavioural Brain Research, 189(1), 92-9. https://doi.org/10.1016/j.bbr.2007.12.015
Alvarez EO, Banzan AM. The Activation of Histamine-sensitive Sites of the Ventral Hippocampus Modulates the Consolidation of a Learned Active Avoidance Response in Rats. Behav Brain Res. 2008 May 16;189(1):92-9. PubMed PMID: 18282618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The activation of histamine-sensitive sites of the ventral hippocampus modulates the consolidation of a learned active avoidance response in rats. AU - Alvarez,Edgardo O, AU - Banzan,Arturo M, Y1 - 2007/12/27/ PY - 2007/12/13/received PY - 2007/12/17/accepted PY - 2008/2/20/pubmed PY - 2008/7/2/medline PY - 2008/2/20/entrez SP - 92 EP - 9 JF - Behavioural brain research JO - Behav Brain Res VL - 189 IS - 1 N2 - Previous evidence from our laboratory has shown that histamine receptors located into the ventral hippocampus modulate learning and memory processes. Stimulation of histamine hippocampal sensitive receptors during the acquisition phase of a conditioned avoidance response to an ultrasonic tone was able to increase latency to escape and impair memory in the rat. Histamine application into the same hippocampal region also impaired the evocation of the response. The purpose of the present work was to evaluate if histaminergic neuron circuits have participation on the consolidation processes of the conditioned avoiding response. Male adult rats were implanted into the ventral hippocampus with microinjection cannulae and subjected consecutively to 2 sessions of 8 trials to learn an avoidance response after an ultrasonic tone of 40 kHz was on, as it was previously described. Immediately after the training period was over, or 15 min after, different groups of rats were microinjected with saline, histamine or a combination of histamine H(1)- or H(2)-receptor antagonists. Twenty four hours later, animals were tested in a new session for the retention of the avoiding response. Results showed that histamine treatment interfered with the consolidation of the avoiding response, affecting latency and the memory efficiency. This interference was mediated by histamine H(1)- and H(2)-receptors, since pretreatment with pyrilamine or ranitidine blocked the inhibitory effect of histamine. Results support the concept that histaminergic neurotransmission modulates learning and memory by affecting selectively the three stages of learning. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/18282618/The_activation_of_histamine_sensitive_sites_of_the_ventral_hippocampus_modulates_the_consolidation_of_a_learned_active_avoidance_response_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(07)00668-7 DB - PRIME DP - Unbound Medicine ER -