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Economics of cardiac adverse events after smallpox vaccination: lessons from the 2003 US Vaccination Program.
Clin Infect Dis. 2008 Mar 15; 46 Suppl 3:S168-78.CI

Abstract

Of >39,000 civilian public health responders vaccinated against smallpox in 2003, 203 reported cardiovascular adverse events (CAEs). An association exists between the US vaccinia strain and myocarditis and/or pericarditis ("myo/pericarditis" [MP]). Other associations are inconclusive. We used surveillance and follow-up survey data of CAE case patients to estimate the resources used during the 2003 smallpox vaccination program and used a probabilistic model to estimate the potential costs of CAEs in a mass vaccination campaign. For every million adult vaccinees, 3001 CAEs (including 351 MP cases) would occur, with >92% in revaccinees. CAEs would require a median of 5934 outpatient visits, 1786 emergency department visits, 533 days in general wards, 132 days in intensive care units, 5484 cardiac enzymes tests, 3504 electrocardiograms, 3049 chemistry tests, 2828 complete blood counts, and 1444 transthoracic echocardiograms, among other procedures. CAEs would reduce productivity (15,969 work days lost) and cost $11 per vaccinee. In a mass vaccination campaign, the care of a sizable number of CAEs would be resource intensive.

Authors+Show Affiliations

National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. IOrtegaSanchez@cdc.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18284356

Citation

Ortega-Sanchez, Ismael R., et al. "Economics of Cardiac Adverse Events After Smallpox Vaccination: Lessons From the 2003 US Vaccination Program." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 46 Suppl 3, 2008, pp. S168-78.
Ortega-Sanchez IR, Sniadack MM, Mootrey GT. Economics of cardiac adverse events after smallpox vaccination: lessons from the 2003 US Vaccination Program. Clin Infect Dis. 2008;46 Suppl 3:S168-78.
Ortega-Sanchez, I. R., Sniadack, M. M., & Mootrey, G. T. (2008). Economics of cardiac adverse events after smallpox vaccination: lessons from the 2003 US Vaccination Program. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 46 Suppl 3, S168-78. https://doi.org/10.1086/524380
Ortega-Sanchez IR, Sniadack MM, Mootrey GT. Economics of Cardiac Adverse Events After Smallpox Vaccination: Lessons From the 2003 US Vaccination Program. Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S168-78. PubMed PMID: 18284356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Economics of cardiac adverse events after smallpox vaccination: lessons from the 2003 US Vaccination Program. AU - Ortega-Sanchez,Ismael R, AU - Sniadack,Mercedes M, AU - Mootrey,Gina T, PY - 2008/3/20/pubmed PY - 2008/4/5/medline PY - 2008/3/20/entrez SP - S168 EP - 78 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 46 Suppl 3 N2 - Of >39,000 civilian public health responders vaccinated against smallpox in 2003, 203 reported cardiovascular adverse events (CAEs). An association exists between the US vaccinia strain and myocarditis and/or pericarditis ("myo/pericarditis" [MP]). Other associations are inconclusive. We used surveillance and follow-up survey data of CAE case patients to estimate the resources used during the 2003 smallpox vaccination program and used a probabilistic model to estimate the potential costs of CAEs in a mass vaccination campaign. For every million adult vaccinees, 3001 CAEs (including 351 MP cases) would occur, with >92% in revaccinees. CAEs would require a median of 5934 outpatient visits, 1786 emergency department visits, 533 days in general wards, 132 days in intensive care units, 5484 cardiac enzymes tests, 3504 electrocardiograms, 3049 chemistry tests, 2828 complete blood counts, and 1444 transthoracic echocardiograms, among other procedures. CAEs would reduce productivity (15,969 work days lost) and cost $11 per vaccinee. In a mass vaccination campaign, the care of a sizable number of CAEs would be resource intensive. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/18284356/Economics_of_cardiac_adverse_events_after_smallpox_vaccination:_lessons_from_the_2003_US_Vaccination_Program_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/524380 DB - PRIME DP - Unbound Medicine ER -