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Dermatological lesions near the smallpox vaccination site after scab detachment.
Clin Infect Dis. 2008 Mar 15; 46 Suppl 3:S227-33.CI

Abstract

Lesions arising after scab detachment at the smallpox vaccination site have been described in the medical literature. We investigated reports of postscab lesions among US civilian volunteers vaccinated against smallpox from January through August 2003. We conducted enhanced surveillance, using a standard questionnaire, for reports of skin lesions appearing at or near the smallpox vaccination site after scab detachment. We identified 21 reports; 19 of the case patients responded to our questionnaire. The lesions (scab and/or fluid) of 7 case patients were tested for vaccinia virus by use of polymerase chain reaction and/or immunohistochemistry; all were found to be negative. We contacted 18 case patients 11 months after the initial lesion appearance; 10 (56%) of the 18 reported having another lesion appear after the initial postscab lesion had resolved. Lesions were heterogeneous in morphology, clinical appearance, and histology. The evidence from our case series and follow-up suggests that these lesions are self-limited, without significant clinical sequelae.

Authors+Show Affiliations

National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Akroger@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18284363

Citation

Kroger, Andrew, et al. "Dermatological Lesions Near the Smallpox Vaccination Site After Scab Detachment." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 46 Suppl 3, 2008, pp. S227-33.
Kroger A, Vellozzi C, Deming M, et al. Dermatological lesions near the smallpox vaccination site after scab detachment. Clin Infect Dis. 2008;46 Suppl 3:S227-33.
Kroger, A., Vellozzi, C., Deming, M., Casey, C. G., Wen, X., & Norton, S. A. (2008). Dermatological lesions near the smallpox vaccination site after scab detachment. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 46 Suppl 3, S227-33. https://doi.org/10.1086/524746
Kroger A, et al. Dermatological Lesions Near the Smallpox Vaccination Site After Scab Detachment. Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S227-33. PubMed PMID: 18284363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dermatological lesions near the smallpox vaccination site after scab detachment. AU - Kroger,Andrew, AU - Vellozzi,Claudia, AU - Deming,Michael, AU - Casey,Christine G, AU - Wen,Xiaojun, AU - Norton,Scott A, PY - 2008/3/20/pubmed PY - 2008/4/5/medline PY - 2008/3/20/entrez SP - S227 EP - 33 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 46 Suppl 3 N2 - Lesions arising after scab detachment at the smallpox vaccination site have been described in the medical literature. We investigated reports of postscab lesions among US civilian volunteers vaccinated against smallpox from January through August 2003. We conducted enhanced surveillance, using a standard questionnaire, for reports of skin lesions appearing at or near the smallpox vaccination site after scab detachment. We identified 21 reports; 19 of the case patients responded to our questionnaire. The lesions (scab and/or fluid) of 7 case patients were tested for vaccinia virus by use of polymerase chain reaction and/or immunohistochemistry; all were found to be negative. We contacted 18 case patients 11 months after the initial lesion appearance; 10 (56%) of the 18 reported having another lesion appear after the initial postscab lesion had resolved. Lesions were heterogeneous in morphology, clinical appearance, and histology. The evidence from our case series and follow-up suggests that these lesions are self-limited, without significant clinical sequelae. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/18284363/Dermatological_lesions_near_the_smallpox_vaccination_site_after_scab_detachment_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/524746 DB - PRIME DP - Unbound Medicine ER -