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Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States, January-October 2003.
Clin Infect Dis. 2008 Mar 15; 46 Suppl 3:S242-50.CI

Abstract

Myocarditis was reported after smallpox vaccination in Europe and Australia, but no association had been reported with the US vaccine. We conducted surveillance to describe and determine the frequency of myocarditis and/or pericarditis (myo/pericarditis) among civilians vaccinated during the US smallpox vaccination program between January and October 2003. We developed surveillance case definitions for myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination. We identified 21 myo/pericarditis cases among 37,901 vaccinees (5.5 per 10,000); 18 (86%) were revacinees, 14 (67%) were women, and the median age was 48 years (range, 25-70 years). The median time from vaccination to onset of symptoms was 11 days (range, 2-42 days). Myo/pericarditis severity was mild, with no fatalities, although 9 patients (43%) were hospitalized. Three additional vaccinees were found to have dilated cardiomyopathy, recognized within 3 months after vaccination. We describe an association between smallpox vaccination, using the US vaccinia strain, and myo/pericarditis among civilians.

Authors+Show Affiliations

Centers for Disease Control and Prevention and 2Department of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18284365

Citation

Morgan, Juliette, et al. "Myocarditis, Pericarditis, and Dilated Cardiomyopathy After Smallpox Vaccination Among Civilians in the United States, January-October 2003." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 46 Suppl 3, 2008, pp. S242-50.
Morgan J, Roper MH, Sperling L, et al. Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States, January-October 2003. Clin Infect Dis. 2008;46 Suppl 3:S242-50.
Morgan, J., Roper, M. H., Sperling, L., Schieber, R. A., Heffelfinger, J. D., Casey, C. G., Miller, J. W., Santibanez, S., Herwaldt, B., Hightower, P., Moro, P. L., Hibbs, B. F., Levine, N. H., Chapman, L. E., Iskander, J., Lane, J. M., Wharton, M., Mootrey, G. T., & Swerdlow, D. L. (2008). Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States, January-October 2003. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 46 Suppl 3, S242-50. https://doi.org/10.1086/524747
Morgan J, et al. Myocarditis, Pericarditis, and Dilated Cardiomyopathy After Smallpox Vaccination Among Civilians in the United States, January-October 2003. Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S242-50. PubMed PMID: 18284365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States, January-October 2003. AU - Morgan,Juliette, AU - Roper,Martha H, AU - Sperling,Laurence, AU - Schieber,Richard A, AU - Heffelfinger,James D, AU - Casey,Christine G, AU - Miller,Jacqueline W, AU - Santibanez,Scott, AU - Herwaldt,Barbara, AU - Hightower,Paige, AU - Moro,Pedro L, AU - Hibbs,Beth F, AU - Levine,Nancy H, AU - Chapman,Louisa E, AU - Iskander,John, AU - Lane,J Michael, AU - Wharton,Melinda, AU - Mootrey,Gina T, AU - Swerdlow,David L, PY - 2008/3/20/pubmed PY - 2008/4/5/medline PY - 2008/3/20/entrez SP - S242 EP - 50 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 46 Suppl 3 N2 - Myocarditis was reported after smallpox vaccination in Europe and Australia, but no association had been reported with the US vaccine. We conducted surveillance to describe and determine the frequency of myocarditis and/or pericarditis (myo/pericarditis) among civilians vaccinated during the US smallpox vaccination program between January and October 2003. We developed surveillance case definitions for myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination. We identified 21 myo/pericarditis cases among 37,901 vaccinees (5.5 per 10,000); 18 (86%) were revacinees, 14 (67%) were women, and the median age was 48 years (range, 25-70 years). The median time from vaccination to onset of symptoms was 11 days (range, 2-42 days). Myo/pericarditis severity was mild, with no fatalities, although 9 patients (43%) were hospitalized. Three additional vaccinees were found to have dilated cardiomyopathy, recognized within 3 months after vaccination. We describe an association between smallpox vaccination, using the US vaccinia strain, and myo/pericarditis among civilians. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/18284365/Myocarditis_pericarditis_and_dilated_cardiomyopathy_after_smallpox_vaccination_among_civilians_in_the_United_States_January_October_2003_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/524747 DB - PRIME DP - Unbound Medicine ER -