Tags

Type your tag names separated by a space and hit enter

Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study.
Am J Rhinol. 2008 Jan-Feb; 22(1):52-8.AJ

Abstract

BACKGROUND

Fungus-driven inflammation is proposed to play an important role in the pathogenesis of chronic rhinosinusitis (CRS). Previous studies tested the efficacy of intranasal antifungal agents for patients with nasal polyps. The purpose of this study was to evaluate the efficacy of intranasal amphotericin B (AMB) in patients who have CRS without nasal polyps (CRSsNP).

METHODS

Patients diagnosed with CRSsNP were enrolled in this study. They were assigned randomly to receive irrigation with AMB solution (20 mg of AMB in 500 mL of normal saline) or placebo (yellowish dye in 500 mL of normal saline) for 4 weeks. The outcome measures included the Chinese version of the Rhinosinusitis Outcome Measure 31 (CRSOM-31), nasal endoscopy, and bacterial and fungal cultures.

RESULTS

Seventy patients were enrolled and 64 patients completed this study. There was significant improvement in the AMB group (n = 32) both in endoscopic (p = 0.013) and CRSOM-31 scores (p < 0.0001). The placebo group (n = 32) showed significant improvement in CRSOM-31 scores (p < 0.0001). CRSOM-31 scores were significantly lower in the AMB group than in the placebo group after 2-week treatment (p = 0.018) and remained lower after 4-week treatment, although the difference was not significant (p = 0.091). There were no significant differences in endoscopic scores and bacterial or fungal culture rates between two groups after treatment.

CONCLUSION

Our results showed that AMB irrigation improved symptoms and endoscopic scores but did not show superiority to saline irrigation alone in patients who have CRSsNP.

Authors+Show Affiliations

Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18284860

Citation

Liang, Kai-Li, et al. "Amphotericin B Irrigation for the Treatment of Chronic Rhinosinusitis Without Nasal Polyps: a Randomized, Placebo-controlled, Double-blind Study." American Journal of Rhinology, vol. 22, no. 1, 2008, pp. 52-8.
Liang KL, Su MC, Shiao JY, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol. 2008;22(1):52-8.
Liang, K. L., Su, M. C., Shiao, J. Y., Tseng, H. C., Hsin, C. H., Lin, J. F., & Jiang, R. S. (2008). Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. American Journal of Rhinology, 22(1), 52-8. https://doi.org/10.2500/ajr.2008.22.3115
Liang KL, et al. Amphotericin B Irrigation for the Treatment of Chronic Rhinosinusitis Without Nasal Polyps: a Randomized, Placebo-controlled, Double-blind Study. Am J Rhinol. 2008;22(1):52-8. PubMed PMID: 18284860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. AU - Liang,Kai-Li, AU - Su,Mao-Chang, AU - Shiao,Jiun-Yi, AU - Tseng,Hung-Cheng, AU - Hsin,Chung-Han, AU - Lin,Jen-Fu, AU - Jiang,Rong-San, PY - 2008/2/21/pubmed PY - 2008/4/9/medline PY - 2008/2/21/entrez SP - 52 EP - 8 JF - American journal of rhinology JO - Am J Rhinol VL - 22 IS - 1 N2 - BACKGROUND: Fungus-driven inflammation is proposed to play an important role in the pathogenesis of chronic rhinosinusitis (CRS). Previous studies tested the efficacy of intranasal antifungal agents for patients with nasal polyps. The purpose of this study was to evaluate the efficacy of intranasal amphotericin B (AMB) in patients who have CRS without nasal polyps (CRSsNP). METHODS: Patients diagnosed with CRSsNP were enrolled in this study. They were assigned randomly to receive irrigation with AMB solution (20 mg of AMB in 500 mL of normal saline) or placebo (yellowish dye in 500 mL of normal saline) for 4 weeks. The outcome measures included the Chinese version of the Rhinosinusitis Outcome Measure 31 (CRSOM-31), nasal endoscopy, and bacterial and fungal cultures. RESULTS: Seventy patients were enrolled and 64 patients completed this study. There was significant improvement in the AMB group (n = 32) both in endoscopic (p = 0.013) and CRSOM-31 scores (p < 0.0001). The placebo group (n = 32) showed significant improvement in CRSOM-31 scores (p < 0.0001). CRSOM-31 scores were significantly lower in the AMB group than in the placebo group after 2-week treatment (p = 0.018) and remained lower after 4-week treatment, although the difference was not significant (p = 0.091). There were no significant differences in endoscopic scores and bacterial or fungal culture rates between two groups after treatment. CONCLUSION: Our results showed that AMB irrigation improved symptoms and endoscopic scores but did not show superiority to saline irrigation alone in patients who have CRSsNP. SN - 1050-6586 UR - https://www.unboundmedicine.com/medline/citation/18284860/Amphotericin_B_irrigation_for_the_treatment_of_chronic_rhinosinusitis_without_nasal_polyps:_a_randomized_placebo_controlled_double_blind_study_ L2 - https://medlineplus.gov/sinusitis.html DB - PRIME DP - Unbound Medicine ER -