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Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?
Arch Biochem Biophys 2008; 476(2):107-12AB

Abstract

Diets rich in polyphenols are epidemiologically associated with lower risk of developing some age-related diseases in humans. This apparent disease-protective effect of polyphenols is often attributed to their powerful antioxidant activities, as established in vitro. However, polyphenols can also exert pro-oxidant activities under certain experimental conditions. Neither pro-oxidant nor anti-oxidant activities have yet been clearly established to occur in vivo in humans, nor are they likely given the limited levels of polyphenols that are achievable in vivo after consumption of foods and beverages rich in them. Other actions of polyphenols may be more important in vivo. Many studies of the biological effects of polyphenols in cell culture have been affected by their ability to oxidise in culture media, and awareness of this problem can avoid erroneous claims.

Authors+Show Affiliations

Department of Biochemistry, National University of Singapore, University Hall, Lee Kong Chian Wing, UHL #05-02G, 21 Lower Kent Ridge Road, Singapore 119077, Singapore. bchbh@nus.edu.sg

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18284912

Citation

Halliwell, Barry. "Are Polyphenols Antioxidants or Pro-oxidants? what Do We Learn From Cell Culture and in Vivo Studies?" Archives of Biochemistry and Biophysics, vol. 476, no. 2, 2008, pp. 107-12.
Halliwell B. Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys. 2008;476(2):107-12.
Halliwell, B. (2008). Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Archives of Biochemistry and Biophysics, 476(2), pp. 107-12. doi:10.1016/j.abb.2008.01.028.
Halliwell B. Are Polyphenols Antioxidants or Pro-oxidants? what Do We Learn From Cell Culture and in Vivo Studies. Arch Biochem Biophys. 2008 Aug 15;476(2):107-12. PubMed PMID: 18284912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? A1 - Halliwell,Barry, Y1 - 2008/02/07/ PY - 2007/11/13/received PY - 2007/12/26/revised PY - 2008/01/29/accepted PY - 2008/2/21/pubmed PY - 2008/8/20/medline PY - 2008/2/21/entrez SP - 107 EP - 12 JF - Archives of biochemistry and biophysics JO - Arch. Biochem. Biophys. VL - 476 IS - 2 N2 - Diets rich in polyphenols are epidemiologically associated with lower risk of developing some age-related diseases in humans. This apparent disease-protective effect of polyphenols is often attributed to their powerful antioxidant activities, as established in vitro. However, polyphenols can also exert pro-oxidant activities under certain experimental conditions. Neither pro-oxidant nor anti-oxidant activities have yet been clearly established to occur in vivo in humans, nor are they likely given the limited levels of polyphenols that are achievable in vivo after consumption of foods and beverages rich in them. Other actions of polyphenols may be more important in vivo. Many studies of the biological effects of polyphenols in cell culture have been affected by their ability to oxidise in culture media, and awareness of this problem can avoid erroneous claims. SN - 1096-0384 UR - https://www.unboundmedicine.com/medline/citation/18284912/Are_polyphenols_antioxidants_or_pro_oxidants_What_do_we_learn_from_cell_culture_and_in_vivo_studies L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(08)00048-9 DB - PRIME DP - Unbound Medicine ER -