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Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis.
Neurology 2008; 70(8):627-33Neur

Abstract

OBJECTIVE

To characterize differences in the prevalence of thrombophilic variables in a large cohort of patients with cerebral venous sinus thrombosis (CVST) and lower extremity deep vein thrombosis (DVT).

METHODS

An inception cohort of individuals was identified with first lifetime incident CVST between 1995 and 2005 for whom comprehensive thrombophilia testing was available. To test the hypothesis that thrombophilia prevalence differs with respect to thrombus location, test results were compared to a randomly selected group of patients with lower extremity DVT with comprehensive thrombophilia testing.

RESULTS

During this time period, 163 patients with CVST were identified who underwent comprehensive thrombophilia testing. Thrombophilia results were abnormal in 29% including anticardiolipin antibodies (17%), heterozygous factor V Leiden (10%), and heterozygous prothrombin G20210A mutation (n = 14/122; 11%). The prothrombin mutation was more than twice as common in patients with CVST (p = 0.04). Activated protein C resistance, factor V Leiden, and protein C deficiency were more common in patients with DVT (p < 0.05 for each comparison). The anticardiolipin antibodies in patients with CVST were primarily low titer IgM isotype.

CONCLUSION

The prevalence of selected thrombophilia factors differs comparing patients with cerebral venous sinus thrombosis and deep vein thrombosis. These differences may offer insights into mechanisms governing the geographic distribution of venous thrombosis.

Authors+Show Affiliations

Division of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18285537

Citation

Wysokinska, E M., et al. "Thrombophilia Differences in Cerebral Venous Sinus and Lower Extremity Deep Venous Thrombosis." Neurology, vol. 70, no. 8, 2008, pp. 627-33.
Wysokinska EM, Wysokinski WE, Brown RD, et al. Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis. Neurology. 2008;70(8):627-33.
Wysokinska, E. M., Wysokinski, W. E., Brown, R. D., Karnicki, K., Gosk-Beirska, I., Grill, D., & McBane, R. D. (2008). Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis. Neurology, 70(8), pp. 627-33. doi:10.1212/01.wnl.0000297195.97325.a8.
Wysokinska EM, et al. Thrombophilia Differences in Cerebral Venous Sinus and Lower Extremity Deep Venous Thrombosis. Neurology. 2008 Feb 19;70(8):627-33. PubMed PMID: 18285537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis. AU - Wysokinska,E M, AU - Wysokinski,W E, AU - Brown,R D, AU - Karnicki,K, AU - Gosk-Beirska,I, AU - Grill,D, AU - McBane,R D,2nd PY - 2008/2/21/pubmed PY - 2008/4/4/medline PY - 2008/2/21/entrez SP - 627 EP - 33 JF - Neurology JO - Neurology VL - 70 IS - 8 N2 - OBJECTIVE: To characterize differences in the prevalence of thrombophilic variables in a large cohort of patients with cerebral venous sinus thrombosis (CVST) and lower extremity deep vein thrombosis (DVT). METHODS: An inception cohort of individuals was identified with first lifetime incident CVST between 1995 and 2005 for whom comprehensive thrombophilia testing was available. To test the hypothesis that thrombophilia prevalence differs with respect to thrombus location, test results were compared to a randomly selected group of patients with lower extremity DVT with comprehensive thrombophilia testing. RESULTS: During this time period, 163 patients with CVST were identified who underwent comprehensive thrombophilia testing. Thrombophilia results were abnormal in 29% including anticardiolipin antibodies (17%), heterozygous factor V Leiden (10%), and heterozygous prothrombin G20210A mutation (n = 14/122; 11%). The prothrombin mutation was more than twice as common in patients with CVST (p = 0.04). Activated protein C resistance, factor V Leiden, and protein C deficiency were more common in patients with DVT (p < 0.05 for each comparison). The anticardiolipin antibodies in patients with CVST were primarily low titer IgM isotype. CONCLUSION: The prevalence of selected thrombophilia factors differs comparing patients with cerebral venous sinus thrombosis and deep vein thrombosis. These differences may offer insights into mechanisms governing the geographic distribution of venous thrombosis. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/18285537/Thrombophilia_differences_in_cerebral_venous_sinus_and_lower_extremity_deep_venous_thrombosis_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=18285537 DB - PRIME DP - Unbound Medicine ER -