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Oral metoclopramide as an adjunct to analgesics for the outpatient treatment of acute migraine.
Ann Pharmacother. 2008 Mar; 42(3):397-402.AP

Abstract

OBJECTIVE

To compare the combination of oral metoclopramide plus an analgesic with oral triptan monotherapy in the treatment of migraine attacks in outpatients.

DATA SOURCES

A search of PubMed (1966-October 2007), EMBASE (1974-October 2007), and International Pharmaceutical Abstracts (1970-October 2007) was conducted using the search terms metoclopramide, migraine, and oral. References of articles identified initially were also reviewed.

STUDY SELECTION AND DATA EXTRACTION

Studies evaluating the efficacy and safety of oral metoclopramide compared with oral triptans for migraine treatment were included. Studies of non-oral forms of metoclopramide or studies that compared oral metoclopramide with placebo, analgesics, ergotamine, or other migraine therapies were excluded. Studies in which oral metoclopramide was combined with a triptan were also excluded.

DATA SYNTHESIS

In the studies identified, oral metoclopramide was combined with aspirin or a similar analgesic. All of the studies assessed headache severity using a 4-point scale (0 = no pain, 1 = mild pain, 2 = moderate pain, 3 = severe pain). Headache relief was defined as a decrease in headache pain from grade 3 or 2 to grade 1 or 0 and was commonly assessed at 2 hours. For all primary and secondary efficacy outcomes-including migraine-associated nausea and vomiting-oral triptans were similar or superior to oral metoclopramide plus an analgesic. The combination was better tolerated, with no reports of serious metoclopramide adverse events such as extrapyramidal symptoms or tardive dyskinesia.

CONCLUSIONS

Combinations containing oral metoclopramide plus an analgesic may be an option for patients in whom triptans are contraindicated or who experience intolerable adverse effects, or when cost is an issue. However, patients and physicians should be aware that the combination will likely be less effective than oral triptans in treatment of migraine and its associated symptoms. To determine the role of combination therapy that includes oral metoclopramide in mild-to-moderate migraines, further studies are warranted.

Authors+Show Affiliations

St. Louis College of Pharmacy, St. Louis, MO 63110, USA. tazzopardi@stlcop.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18285561

Citation

Azzopardi, Terri D., and Natalie A. Brooks. "Oral Metoclopramide as an Adjunct to Analgesics for the Outpatient Treatment of Acute Migraine." The Annals of Pharmacotherapy, vol. 42, no. 3, 2008, pp. 397-402.
Azzopardi TD, Brooks NA. Oral metoclopramide as an adjunct to analgesics for the outpatient treatment of acute migraine. Ann Pharmacother. 2008;42(3):397-402.
Azzopardi, T. D., & Brooks, N. A. (2008). Oral metoclopramide as an adjunct to analgesics for the outpatient treatment of acute migraine. The Annals of Pharmacotherapy, 42(3), 397-402. https://doi.org/10.1345/aph.1K481
Azzopardi TD, Brooks NA. Oral Metoclopramide as an Adjunct to Analgesics for the Outpatient Treatment of Acute Migraine. Ann Pharmacother. 2008;42(3):397-402. PubMed PMID: 18285561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral metoclopramide as an adjunct to analgesics for the outpatient treatment of acute migraine. AU - Azzopardi,Terri D, AU - Brooks,Natalie A, Y1 - 2008/02/19/ PY - 2008/2/21/pubmed PY - 2008/7/30/medline PY - 2008/2/21/entrez SP - 397 EP - 402 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 42 IS - 3 N2 - OBJECTIVE: To compare the combination of oral metoclopramide plus an analgesic with oral triptan monotherapy in the treatment of migraine attacks in outpatients. DATA SOURCES: A search of PubMed (1966-October 2007), EMBASE (1974-October 2007), and International Pharmaceutical Abstracts (1970-October 2007) was conducted using the search terms metoclopramide, migraine, and oral. References of articles identified initially were also reviewed. STUDY SELECTION AND DATA EXTRACTION: Studies evaluating the efficacy and safety of oral metoclopramide compared with oral triptans for migraine treatment were included. Studies of non-oral forms of metoclopramide or studies that compared oral metoclopramide with placebo, analgesics, ergotamine, or other migraine therapies were excluded. Studies in which oral metoclopramide was combined with a triptan were also excluded. DATA SYNTHESIS: In the studies identified, oral metoclopramide was combined with aspirin or a similar analgesic. All of the studies assessed headache severity using a 4-point scale (0 = no pain, 1 = mild pain, 2 = moderate pain, 3 = severe pain). Headache relief was defined as a decrease in headache pain from grade 3 or 2 to grade 1 or 0 and was commonly assessed at 2 hours. For all primary and secondary efficacy outcomes-including migraine-associated nausea and vomiting-oral triptans were similar or superior to oral metoclopramide plus an analgesic. The combination was better tolerated, with no reports of serious metoclopramide adverse events such as extrapyramidal symptoms or tardive dyskinesia. CONCLUSIONS: Combinations containing oral metoclopramide plus an analgesic may be an option for patients in whom triptans are contraindicated or who experience intolerable adverse effects, or when cost is an issue. However, patients and physicians should be aware that the combination will likely be less effective than oral triptans in treatment of migraine and its associated symptoms. To determine the role of combination therapy that includes oral metoclopramide in mild-to-moderate migraines, further studies are warranted. SN - 1542-6270 UR - https://www.unboundmedicine.com/medline/citation/18285561/Oral_metoclopramide_as_an_adjunct_to_analgesics_for_the_outpatient_treatment_of_acute_migraine_ L2 - https://journals.sagepub.com/doi/10.1345/aph.1K481?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -