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Beware the solitary maxillary median central incisor.
J Orthod 2008; 35(1):16-9JO

Abstract

The incidence of a solitary maxillary median central incisor (SMMCI) tooth in the general population is low, in either the primary or secondary dentition. The most common cause of a missing maxillary central incisor is trauma, or more rarely hypodontia. However, SMMCI is also a recognized genetic anomaly and affected individuals can be carriers for a potentially more serious condition affecting midline development of the brain and face, holoprosencephaly (HPE). The presence of an SMMCI of unknown aetiology is therefore considered a risk factor for HPE, even in the absence of any other clinical signs. The orthodontist may be responsible for diagnosing cases of SMMCI with no obvious cause, and in these subjects due consideration should be given to referral for the appropriate genetic testing and counselling.

Authors+Show Affiliations

Department of Orthodontics, East Kent Hospitals NHS Trust, Canterbury, Kent, UK.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18287390

Citation

DiBiase, Andrew T., and Martyn T. Cobourne. "Beware the Solitary Maxillary Median Central Incisor." Journal of Orthodontics, vol. 35, no. 1, 2008, pp. 16-9.
DiBiase AT, Cobourne MT. Beware the solitary maxillary median central incisor. J Orthod. 2008;35(1):16-9.
DiBiase, A. T., & Cobourne, M. T. (2008). Beware the solitary maxillary median central incisor. Journal of Orthodontics, 35(1), pp. 16-9. doi:10.1179/146531207225022365.
DiBiase AT, Cobourne MT. Beware the Solitary Maxillary Median Central Incisor. J Orthod. 2008;35(1):16-9. PubMed PMID: 18287390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beware the solitary maxillary median central incisor. AU - DiBiase,Andrew T, AU - Cobourne,Martyn T, PY - 2008/2/22/pubmed PY - 2008/4/26/medline PY - 2008/2/22/entrez SP - 16 EP - 9 JF - Journal of orthodontics JO - J Orthod VL - 35 IS - 1 N2 - The incidence of a solitary maxillary median central incisor (SMMCI) tooth in the general population is low, in either the primary or secondary dentition. The most common cause of a missing maxillary central incisor is trauma, or more rarely hypodontia. However, SMMCI is also a recognized genetic anomaly and affected individuals can be carriers for a potentially more serious condition affecting midline development of the brain and face, holoprosencephaly (HPE). The presence of an SMMCI of unknown aetiology is therefore considered a risk factor for HPE, even in the absence of any other clinical signs. The orthodontist may be responsible for diagnosing cases of SMMCI with no obvious cause, and in these subjects due consideration should be given to referral for the appropriate genetic testing and counselling. SN - 1465-3125 UR - https://www.unboundmedicine.com/medline/citation/18287390/Beware_the_solitary_maxillary_median_central_incisor_ L2 - http://journals.sagepub.com/doi/full/10.1179/146531207225022365?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -