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Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
N Engl J Med 2008; 358(8):811-7NEJM

Abstract

Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.

Authors+Show Affiliations

Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France. kamar.n@chu-toulouse.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18287603

Citation

Kamar, Nassim, et al. "Hepatitis E Virus and Chronic Hepatitis in Organ-transplant Recipients." The New England Journal of Medicine, vol. 358, no. 8, 2008, pp. 811-7.
Kamar N, Selves J, Mansuy JM, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med. 2008;358(8):811-7.
Kamar, N., Selves, J., Mansuy, J. M., Ouezzani, L., Péron, J. M., Guitard, J., ... Rostaing, L. (2008). Hepatitis E virus and chronic hepatitis in organ-transplant recipients. The New England Journal of Medicine, 358(8), pp. 811-7. doi:10.1056/NEJMoa0706992.
Kamar N, et al. Hepatitis E Virus and Chronic Hepatitis in Organ-transplant Recipients. N Engl J Med. 2008 Feb 21;358(8):811-7. PubMed PMID: 18287603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E virus and chronic hepatitis in organ-transplant recipients. AU - Kamar,Nassim, AU - Selves,Janick, AU - Mansuy,Jean-Michel, AU - Ouezzani,Leila, AU - Péron,Jean-Marie, AU - Guitard,Joëlle, AU - Cointault,Olivier, AU - Esposito,Laure, AU - Abravanel,Florence, AU - Danjoux,Marie, AU - Durand,Dominique, AU - Vinel,Jean-Pierre, AU - Izopet,Jacques, AU - Rostaing,Lionel, PY - 2008/2/22/pubmed PY - 2008/2/27/medline PY - 2008/2/22/entrez SP - 811 EP - 7 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 358 IS - 8 N2 - Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/18287603/full_citation L2 - http://www.nejm.org/doi/full/10.1056/NEJMoa0706992?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -