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Hepatitis E virus and chronic hepatitis in organ-transplant recipients.

Abstract

Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.

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  • Authors+Show Affiliations

    ,

    Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France. kamar.n@chu-toulouse.fr

    , , , , , , , , , , , ,

    Source

    The New England journal of medicine 358:8 2008 Feb 21 pg 811-7

    MeSH

    Adult
    Aged
    Female
    Hepatitis E
    Hepatitis E virus
    Hepatitis, Chronic
    Humans
    Immunocompromised Host
    Kidney Transplantation
    Liver
    Liver Function Tests
    Liver Transplantation
    Male
    Middle Aged
    Pancreas Transplantation

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18287603

    Citation

    Kamar, Nassim, et al. "Hepatitis E Virus and Chronic Hepatitis in Organ-transplant Recipients." The New England Journal of Medicine, vol. 358, no. 8, 2008, pp. 811-7.
    Kamar N, Selves J, Mansuy JM, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med. 2008;358(8):811-7.
    Kamar, N., Selves, J., Mansuy, J. M., Ouezzani, L., Péron, J. M., Guitard, J., ... Rostaing, L. (2008). Hepatitis E virus and chronic hepatitis in organ-transplant recipients. The New England Journal of Medicine, 358(8), pp. 811-7. doi:10.1056/NEJMoa0706992.
    Kamar N, et al. Hepatitis E Virus and Chronic Hepatitis in Organ-transplant Recipients. N Engl J Med. 2008 Feb 21;358(8):811-7. PubMed PMID: 18287603.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatitis E virus and chronic hepatitis in organ-transplant recipients. AU - Kamar,Nassim, AU - Selves,Janick, AU - Mansuy,Jean-Michel, AU - Ouezzani,Leila, AU - Péron,Jean-Marie, AU - Guitard,Joëlle, AU - Cointault,Olivier, AU - Esposito,Laure, AU - Abravanel,Florence, AU - Danjoux,Marie, AU - Durand,Dominique, AU - Vinel,Jean-Pierre, AU - Izopet,Jacques, AU - Rostaing,Lionel, PY - 2008/2/22/pubmed PY - 2008/2/27/medline PY - 2008/2/22/entrez SP - 811 EP - 7 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 358 IS - 8 N2 - Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/18287603/full_citation L2 - https://www.nejm.org/doi/10.1056/NEJMoa0706992?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=www.ncbi.nlm.nih.gov DB - PRIME DP - Unbound Medicine ER -