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Pulse wave velocity is associated with metabolic syndrome components in CAPD patients.
Am J Nephrol. 2008; 28(4):641-6.AJ

Abstract

BACKGROUND

Overall, the proportion of deaths due to cardiovascular disease (CVD) reached 40-50% in dialysis patients. Pulse wave velocity (PWV) reflects arterial stiffness and may provide an integrated index of vascular status and CVD risk. Individual components of the metabolic syndrome (MetS) are well-established cardiovascular risk factors. Thus we conducted a cross-sectional study in continuous ambulatory peritoneal dialysis (CAPD) patients to explore the association of MetS components with PWV.

METHODS

Prevalent CAPD patients (n = 148, 63 M/85 F) were categorized according to the number of traits of the MetS into one of three groups (No MetS, Risk of MetS, MetS). Due to the effect of peritoneal dialysis (PD), waist circumference was not assessed. Aortic stiffness was assessed by carotid-femoral PWV (C-F PWV).

RESULTS

Patients' MetS trait numbers were positively associated with C-F PWV (r = 0.301, p < 0.01), pulse pressure (r = 0.256, p < 0.01), systolic blood pressure (r = 0.233, p < 0.01), and serum albumin (r = 0.205, p < 0.05). In a multivariate regression analysis, PWV was independently determined by age (p < 0.01) and MetS score (p = 0.01). Adjusted R(2) of the model was 0.24.

CONCLUSION

MetS traits were closely associated with an increased C-F PWV, even after adjustment for confounders. This suggests that commonly recognized MetS criteria are useful also when predicting CVD in CAPD patients.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhe XW
Division of Nephrology, Peking University Third Hospital, Beijing, PR China.
Zeng J
No affiliation info available
Tian XK
No affiliation info available
Chen W
No affiliation info available
Gu Y
No affiliation info available
Cheng LT
No affiliation info available
Chen HM
No affiliation info available
Axelsson J
No affiliation info available
Lindholm B
No affiliation info available
Wang T
No affiliation info available

MeSH

Blood PressureCardiovascular DiseasesCross-Sectional StudiesFemaleHumansMaleMetabolic SyndromeMiddle AgedPeritoneal Dialysis, Continuous AmbulatoryPulseRisk FactorsSerum Albumin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18287789

Citation

Zhe, Xing-wei, et al. "Pulse Wave Velocity Is Associated With Metabolic Syndrome Components in CAPD Patients." American Journal of Nephrology, vol. 28, no. 4, 2008, pp. 641-6.
Zhe XW, Zeng J, Tian XK, et al. Pulse wave velocity is associated with metabolic syndrome components in CAPD patients. Am J Nephrol. 2008;28(4):641-6.
Zhe, X. W., Zeng, J., Tian, X. K., Chen, W., Gu, Y., Cheng, L. T., Chen, H. M., Axelsson, J., Lindholm, B., & Wang, T. (2008). Pulse wave velocity is associated with metabolic syndrome components in CAPD patients. American Journal of Nephrology, 28(4), 641-6. https://doi.org/10.1159/000117813
Zhe XW, et al. Pulse Wave Velocity Is Associated With Metabolic Syndrome Components in CAPD Patients. Am J Nephrol. 2008;28(4):641-6. PubMed PMID: 18287789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulse wave velocity is associated with metabolic syndrome components in CAPD patients. AU - Zhe,Xing-wei, AU - Zeng,Jing, AU - Tian,Xin-kui, AU - Chen,Wei, AU - Gu,Yue, AU - Cheng,Li-tao, AU - Chen,Hui-min, AU - Axelsson,Jonas, AU - Lindholm,Bengt, AU - Wang,Tao, Y1 - 2008/02/21/ PY - 2007/09/04/received PY - 2007/12/19/accepted PY - 2008/2/22/pubmed PY - 2008/7/29/medline PY - 2008/2/22/entrez SP - 641 EP - 6 JF - American journal of nephrology JO - Am J Nephrol VL - 28 IS - 4 N2 - BACKGROUND: Overall, the proportion of deaths due to cardiovascular disease (CVD) reached 40-50% in dialysis patients. Pulse wave velocity (PWV) reflects arterial stiffness and may provide an integrated index of vascular status and CVD risk. Individual components of the metabolic syndrome (MetS) are well-established cardiovascular risk factors. Thus we conducted a cross-sectional study in continuous ambulatory peritoneal dialysis (CAPD) patients to explore the association of MetS components with PWV. METHODS: Prevalent CAPD patients (n = 148, 63 M/85 F) were categorized according to the number of traits of the MetS into one of three groups (No MetS, Risk of MetS, MetS). Due to the effect of peritoneal dialysis (PD), waist circumference was not assessed. Aortic stiffness was assessed by carotid-femoral PWV (C-F PWV). RESULTS: Patients' MetS trait numbers were positively associated with C-F PWV (r = 0.301, p < 0.01), pulse pressure (r = 0.256, p < 0.01), systolic blood pressure (r = 0.233, p < 0.01), and serum albumin (r = 0.205, p < 0.05). In a multivariate regression analysis, PWV was independently determined by age (p < 0.01) and MetS score (p = 0.01). Adjusted R(2) of the model was 0.24. CONCLUSION: MetS traits were closely associated with an increased C-F PWV, even after adjustment for confounders. This suggests that commonly recognized MetS criteria are useful also when predicting CVD in CAPD patients. SN - 1421-9670 UR - https://www.unboundmedicine.com/medline/citation/18287789/Pulse_wave_velocity_is_associated_with_metabolic_syndrome_components_in_CAPD_patients_ DB - PRIME DP - Unbound Medicine ER -