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Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population.
Eur J Cancer Prev. 2008 Apr; 17(2):77-81.EJ

Abstract

Polymorphisms in the gene encoding the metabolic enzyme cytochrome P450 1A1 (CYP1A1) might contribute to the variability in individual susceptibility to gallbladder cancer (GBC). This study comprised 142 consecutive cases of proven GBC and 171 healthy participants of similar ethnicity. CYP1A1 6235 T/C transition was analyzed using polymerase chain reaction-restriction fragment length polymorphism. The CC genotype of CYP1A1 was significantly associated with a risk of GBC [odds ratio (OR) 2.3, 95% confidence interval (CI)=1.1-4.5, P=0.026], and the age- and sex-adjusted OR was 2.0. The CYP1A1 C allele frequency was also higher in GBC patients (OR 1.4, 95% CI=1.0-2.0, P=0.039). After sex stratification, the TC genotype and C allele were significantly higher in men and conferred a risk for GBC (OR 4.2, 95% CI=1.8-9.7, P=0.001; OR 2.2, CI=1.3-3.7, P=0.005). In addition, the TC genotype and C allele frequencies were significantly higher in GBC patients without associated gallstones (OR 2.4, 95% CI=1.2-4.7, P=0.011; OR 1.6, CI=1.0-2.4, P=0.023). The usage of tobacco (smoking or nonsmoking) by GBC patients showed a significant increase in cancer risk with the TC genotype (OR 4.1, 95% CI=1.3-11.9, P=0.012). It seems that the higher risk of the TC genotype in men may be related to tobacco usage.

Authors+Show Affiliations

Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18287863

Citation

Pandey, Sachchida Nand, et al. "Association of CYP1A1 Msp1 Polymorphism With Tobacco-related Risk of Gallbladder Cancer in a North Indian Population." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 17, no. 2, 2008, pp. 77-81.
Pandey SN, Choudhuri G, Mittal B. Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. Eur J Cancer Prev. 2008;17(2):77-81.
Pandey, S. N., Choudhuri, G., & Mittal, B. (2008). Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 17(2), 77-81. https://doi.org/10.1097/CEJ.0b013e3282b6fdd2
Pandey SN, Choudhuri G, Mittal B. Association of CYP1A1 Msp1 Polymorphism With Tobacco-related Risk of Gallbladder Cancer in a North Indian Population. Eur J Cancer Prev. 2008;17(2):77-81. PubMed PMID: 18287863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. AU - Pandey,Sachchida Nand, AU - Choudhuri,Gourdas, AU - Mittal,Balraj, PY - 2008/2/22/pubmed PY - 2008/6/26/medline PY - 2008/2/22/entrez SP - 77 EP - 81 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 17 IS - 2 N2 - Polymorphisms in the gene encoding the metabolic enzyme cytochrome P450 1A1 (CYP1A1) might contribute to the variability in individual susceptibility to gallbladder cancer (GBC). This study comprised 142 consecutive cases of proven GBC and 171 healthy participants of similar ethnicity. CYP1A1 6235 T/C transition was analyzed using polymerase chain reaction-restriction fragment length polymorphism. The CC genotype of CYP1A1 was significantly associated with a risk of GBC [odds ratio (OR) 2.3, 95% confidence interval (CI)=1.1-4.5, P=0.026], and the age- and sex-adjusted OR was 2.0. The CYP1A1 C allele frequency was also higher in GBC patients (OR 1.4, 95% CI=1.0-2.0, P=0.039). After sex stratification, the TC genotype and C allele were significantly higher in men and conferred a risk for GBC (OR 4.2, 95% CI=1.8-9.7, P=0.001; OR 2.2, CI=1.3-3.7, P=0.005). In addition, the TC genotype and C allele frequencies were significantly higher in GBC patients without associated gallstones (OR 2.4, 95% CI=1.2-4.7, P=0.011; OR 1.6, CI=1.0-2.4, P=0.023). The usage of tobacco (smoking or nonsmoking) by GBC patients showed a significant increase in cancer risk with the TC genotype (OR 4.1, 95% CI=1.3-11.9, P=0.012). It seems that the higher risk of the TC genotype in men may be related to tobacco usage. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/18287863/Association_of_CYP1A1_Msp1_polymorphism_with_tobacco_related_risk_of_gallbladder_cancer_in_a_north_Indian_population_ L2 - http://dx.doi.org/10.1097/CEJ.0b013e3282b6fdd2 DB - PRIME DP - Unbound Medicine ER -