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Nonsteroidal anti-inflammatory drug use and breast cancer risk: a Danish cohort study.
Eur J Cancer Prev. 2008 Apr; 17(2):88-96.EJ

Abstract

Epidemiologic studies investigating the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer have yielded conflicting results. We examined the association between use of aspirin and nonaspirin NSAIDs and breast cancer risk among 28 695 women in the Danish Diet, Cancer and Health cohort. Information on NSAID and paracetamol use was obtained from a self-administered questionnaire completed at baseline (1993-1997) and updated through 2003 using a nationwide prescription database. Detailed information on breast cancer incidence and tumour characteristics was obtained from nationwide health registers. Cox proportional hazards regression was used to compute incidence rate ratios (RRs) and 95% confidence intervals (CIs). We identified 847 breast cancer cases over an average follow-up period of 7.5 years. Any NSAID use at baseline was associated with an increased incidence of breast cancer compared with nonuse (RR, 1.27; 95% CI, 1.10-1.45). A similar result was observed for any NSAID use in a combined analysis of baseline and prescription data (1.34; 95% CI, 1.15-1.56). Aspirin-only users experienced a slightly higher breast cancer incidence (RR, 1.38; 95% CI, 1.12-1.69) than exclusive users of nonaspirin NSAIDs (RR, 1.25; 95% CI, 1.04-1.49). Introduction of a lag time of 1 year provided similar results. We found no clear differences in risk estimates with frequency, recency or duration of NSAID use, or by hormone receptor status of the breast tumours. Paracetamol use was unrelated to breast cancer incidence. The increased breast cancer incidence among NSAID users may reflect a noncausal association, but our study provides no evidence of a chemopreventive effect of NSAIDs against breast cancer over the durations studied.

Authors+Show Affiliations

Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. friis@cancer.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18287865

Citation

Friis, Søren, et al. "Nonsteroidal Anti-inflammatory Drug Use and Breast Cancer Risk: a Danish Cohort Study." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 17, no. 2, 2008, pp. 88-96.
Friis S, Thomassen L, Sørensen HT, et al. Nonsteroidal anti-inflammatory drug use and breast cancer risk: a Danish cohort study. Eur J Cancer Prev. 2008;17(2):88-96.
Friis, S., Thomassen, L., Sørensen, H. T., Tjønneland, A., Overvad, K., Cronin-Fenton, D. P., Vogel, U., McLaughlin, J. K., Blot, W. J., & Olsen, J. H. (2008). Nonsteroidal anti-inflammatory drug use and breast cancer risk: a Danish cohort study. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 17(2), 88-96. https://doi.org/10.1097/CEJ.0b013e3282b6fd55
Friis S, et al. Nonsteroidal Anti-inflammatory Drug Use and Breast Cancer Risk: a Danish Cohort Study. Eur J Cancer Prev. 2008;17(2):88-96. PubMed PMID: 18287865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonsteroidal anti-inflammatory drug use and breast cancer risk: a Danish cohort study. AU - Friis,Søren, AU - Thomassen,Lars, AU - Sørensen,Henrik T, AU - Tjønneland,Anne, AU - Overvad,Kim, AU - Cronin-Fenton,Deirdre P, AU - Vogel,Ulla, AU - McLaughlin,Joseph K, AU - Blot,William J, AU - Olsen,Jørgen H, PY - 2008/2/22/pubmed PY - 2008/6/26/medline PY - 2008/2/22/entrez SP - 88 EP - 96 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 17 IS - 2 N2 - Epidemiologic studies investigating the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer have yielded conflicting results. We examined the association between use of aspirin and nonaspirin NSAIDs and breast cancer risk among 28 695 women in the Danish Diet, Cancer and Health cohort. Information on NSAID and paracetamol use was obtained from a self-administered questionnaire completed at baseline (1993-1997) and updated through 2003 using a nationwide prescription database. Detailed information on breast cancer incidence and tumour characteristics was obtained from nationwide health registers. Cox proportional hazards regression was used to compute incidence rate ratios (RRs) and 95% confidence intervals (CIs). We identified 847 breast cancer cases over an average follow-up period of 7.5 years. Any NSAID use at baseline was associated with an increased incidence of breast cancer compared with nonuse (RR, 1.27; 95% CI, 1.10-1.45). A similar result was observed for any NSAID use in a combined analysis of baseline and prescription data (1.34; 95% CI, 1.15-1.56). Aspirin-only users experienced a slightly higher breast cancer incidence (RR, 1.38; 95% CI, 1.12-1.69) than exclusive users of nonaspirin NSAIDs (RR, 1.25; 95% CI, 1.04-1.49). Introduction of a lag time of 1 year provided similar results. We found no clear differences in risk estimates with frequency, recency or duration of NSAID use, or by hormone receptor status of the breast tumours. Paracetamol use was unrelated to breast cancer incidence. The increased breast cancer incidence among NSAID users may reflect a noncausal association, but our study provides no evidence of a chemopreventive effect of NSAIDs against breast cancer over the durations studied. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/18287865/Nonsteroidal_anti_inflammatory_drug_use_and_breast_cancer_risk:_a_Danish_cohort_study_ L2 - http://dx.doi.org/10.1097/CEJ.0b013e3282b6fd55 DB - PRIME DP - Unbound Medicine ER -