TY - JOUR T1 - Proline-catalysed Mannich reactions of acetaldehyde. AU - Yang,Jung Woon, AU - Chandler,Carley, AU - Stadler,Michael, AU - Kampen,Daniela, AU - List,Benjamin, Y1 - 2008/02/20/ PY - 2007/11/09/received PY - 2008/01/22/accepted PY - 2008/2/22/pubmed PY - 2008/5/1/medline PY - 2008/2/22/entrez SP - 453 EP - 5 JF - Nature JO - Nature VL - 452 IS - 7186 N2 - Small organic molecules recently emerged as a third class of broadly useful asymmetric catalysts that direct reactions to yield predominantly one chiral product, complementing enzymes and metal complexes. For instance, the amino acid proline and its derivatives are useful for the catalytic activation of carbonyl compounds via nucleophilic enamine intermediates. Several important carbon-carbon bond-forming reactions, including the Mannich reaction, have been developed using this approach, all of which are useful for making chiral, biologically relevant compounds. Remarkably, despite attempts, the simplest of all nucleophiles, acetaldehyde, could not be used in this way. Here we show that acetaldehyde is a powerful nucleophile in asymmetric, proline-catalysed Mannich reactions with N-tert-butoxycarbonyl (N-Boc)-imines, yielding beta-amino aldehydes with extremely high enantioselectivities-desirable products as drug intermediates and in the synthesis of other biologically active molecules. Although acetaldehyde has been used as a nucleophile in reactions with biological catalysts such as aldolases and thiamine-dependent enzymes, and has also been employed indirectly, its use as an inexpensive and versatile two-carbon nucleophile in asymmetric, small-molecule catalysis will find many practical applications. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/18288105/Proline_catalysed_Mannich_reactions_of_acetaldehyde_ DB - PRIME DP - Unbound Medicine ER -