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[Coagulation and fibrinolysis parameters in disseminated intravascular coagulation (DIC)].
Rinsho Byori. 1991 Mar; 39(3):309-14.RB

Abstract

Eighty six plasma samples from 41 patients with suspected disseminated intravascular coagulation (DIC) were divided into 3 groups as follows: Group A, 53 samples from established DIC; Group B, 19 samples from possible DIC; and Group C, 14 samples from probable DIC. The following parameters of coagulation and fibrinolysis were evaluated: thrombin/antithrombin III complex (TAT), plasmin/alpha 2 plasmin inhibitor complex (PIC), D-dimer (D-D) and fibrin monomer (FM). In Group A, TAT and PIC were significantly elevated, being 29.5 +/- 20.7 micrograms/l and 7.2 +/- 6.1 mg/l respectively, suggesting marked hypercoagulability and accelerated fibrinolysis. There were no correlations between antithrombin III (ATIII) and TAT, between alpha 2 plasmin inhibitor (alpha 2PI) and PIC, or between TAT and PIC, showing the clinical diversity of patients with DIC. In all groups abnormal TAT, PIC and D-D findings were observed in many samples (86-100%), and FM was present in 83%, 63%, and 29% of samples in Groups A, B, and C respectively. In Groups B and C, abnormal findings for TAT, PIC, D-D, FM and alpha 2PI apparently indicated hypercoagulability and accelerated fibrinolysis, even though fibrinogen and platelet count were within normal limits.

Authors+Show Affiliations

Department of Laboratory Medicine, Niigata Cancer Center Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1828842

Citation

Nakagawa, T, et al. "[Coagulation and Fibrinolysis Parameters in Disseminated Intravascular Coagulation (DIC)]." Rinsho Byori. the Japanese Journal of Clinical Pathology, vol. 39, no. 3, 1991, pp. 309-14.
Nakagawa T, Saito H, Watanabe Y, et al. [Coagulation and fibrinolysis parameters in disseminated intravascular coagulation (DIC)]. Rinsho Byori. 1991;39(3):309-14.
Nakagawa, T., Saito, H., Watanabe, Y., Sato, M., & Murakawa, E. (1991). [Coagulation and fibrinolysis parameters in disseminated intravascular coagulation (DIC)]. Rinsho Byori. the Japanese Journal of Clinical Pathology, 39(3), 309-14.
Nakagawa T, et al. [Coagulation and Fibrinolysis Parameters in Disseminated Intravascular Coagulation (DIC)]. Rinsho Byori. 1991;39(3):309-14. PubMed PMID: 1828842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Coagulation and fibrinolysis parameters in disseminated intravascular coagulation (DIC)]. AU - Nakagawa,T, AU - Saito,H, AU - Watanabe,Y, AU - Sato,M, AU - Murakawa,E, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 309 EP - 14 JF - Rinsho byori. The Japanese journal of clinical pathology JO - Rinsho Byori VL - 39 IS - 3 N2 - Eighty six plasma samples from 41 patients with suspected disseminated intravascular coagulation (DIC) were divided into 3 groups as follows: Group A, 53 samples from established DIC; Group B, 19 samples from possible DIC; and Group C, 14 samples from probable DIC. The following parameters of coagulation and fibrinolysis were evaluated: thrombin/antithrombin III complex (TAT), plasmin/alpha 2 plasmin inhibitor complex (PIC), D-dimer (D-D) and fibrin monomer (FM). In Group A, TAT and PIC were significantly elevated, being 29.5 +/- 20.7 micrograms/l and 7.2 +/- 6.1 mg/l respectively, suggesting marked hypercoagulability and accelerated fibrinolysis. There were no correlations between antithrombin III (ATIII) and TAT, between alpha 2 plasmin inhibitor (alpha 2PI) and PIC, or between TAT and PIC, showing the clinical diversity of patients with DIC. In all groups abnormal TAT, PIC and D-D findings were observed in many samples (86-100%), and FM was present in 83%, 63%, and 29% of samples in Groups A, B, and C respectively. In Groups B and C, abnormal findings for TAT, PIC, D-D, FM and alpha 2PI apparently indicated hypercoagulability and accelerated fibrinolysis, even though fibrinogen and platelet count were within normal limits. SN - 0047-1860 UR - https://www.unboundmedicine.com/medline/citation/1828842/[Coagulation_and_fibrinolysis_parameters_in_disseminated_intravascular_coagulation__DIC_]_ L2 - https://www.medicalonline.jp/meteo_linkout.php?issn=0047-1860&volume=39&issue=3&spage=309 DB - PRIME DP - Unbound Medicine ER -