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Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease.
Atherosclerosis. 2008 Jul; 199(1):179-86.A

Abstract

The single nucleotide polymorphisms (SNPs) apolipoprotein E (APOE) epsilon3/epsilon2/epsilon4, cholesteryl ester transfer protein (CETP) TaqIB, and apolipoprotein C3 (APOC3) -482 C>T have been associated with an atherogenic lipid profile and, in some studies, with increased cardiovascular risk. However, no data exist on their combined impact on atherosclerotic disease. We therefore aimed at investigating the combined impact of these SNPs on the presence of angiographically determined coronary artery disease (CAD). Genotyping was performed in 557 consecutive Caucasian patients undergoing coronary angiography for the evaluation of CAD. From the individual SNPs, only the APOE epsilon3epsilon4/epsilon4epsilon4 genotype was significantly associated with an increased risk of significant coronary stenoses with lumen narrowing >or=50% (odds ratio (OR)=1.77 [1.16-2.71]; p=0.008). However, the risk of CAD strongly increased when more than one of the analysed genetic variants was present: ORs were 2.74 [1.29-5.83]; p=0.009 for patients with both the APOE epsilon3epsilon4/epsilon4epsilon4 and the CETP B1B1 genotype, 1.97 [1.06-3.66]; p=0.031 for patients with both the APOE epsilon3epsilon4/epsilon4epsilon4 genotype and the APOC3 -482T allele, 2.12 [1.31-3.44]; p=0.002 for patients with both the CETP B1B1 genotype and the APOC3 -482T allele, and 3.99 [1.57-13.79]; p=0.029 for patients with all three variants. Multivariate analyses confirmed these results. We conclude that there are strong synergistic effects of the APOE epsilon3/epsilon2/epsilon4, the CETP TaqIB, and the APOC3 -482 C>T polymorphisms on their association with CAD.

Authors+Show Affiliations

Vorarlberg Institute for Vascular Investigation and Treatment, A 6800 Feldkirch, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18289550

Citation

Muendlein, A, et al. "Synergistic Effects of the Apolipoprotein E Epsilon3/epsilon2/epsilon4, the Cholesteryl Ester Transfer Protein TaqIB, and the Apolipoprotein C3 -482 C>T Polymorphisms On Their Association With Coronary Artery Disease." Atherosclerosis, vol. 199, no. 1, 2008, pp. 179-86.
Muendlein A, Saely CH, Marte T, et al. Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease. Atherosclerosis. 2008;199(1):179-86.
Muendlein, A., Saely, C. H., Marte, T., Schmid, F., Koch, L., Rein, P., Langer, P., Aczel, S., & Drexel, H. (2008). Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease. Atherosclerosis, 199(1), 179-86. https://doi.org/10.1016/j.atherosclerosis.2007.10.030
Muendlein A, et al. Synergistic Effects of the Apolipoprotein E Epsilon3/epsilon2/epsilon4, the Cholesteryl Ester Transfer Protein TaqIB, and the Apolipoprotein C3 -482 C>T Polymorphisms On Their Association With Coronary Artery Disease. Atherosclerosis. 2008;199(1):179-86. PubMed PMID: 18289550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease. AU - Muendlein,A, AU - Saely,C H, AU - Marte,T, AU - Schmid,F, AU - Koch,L, AU - Rein,P, AU - Langer,P, AU - Aczel,S, AU - Drexel,H, Y1 - 2008/03/04/ PY - 2007/06/21/received PY - 2007/10/01/revised PY - 2007/10/12/accepted PY - 2008/2/22/pubmed PY - 2008/8/8/medline PY - 2008/2/22/entrez SP - 179 EP - 86 JF - Atherosclerosis JO - Atherosclerosis VL - 199 IS - 1 N2 - The single nucleotide polymorphisms (SNPs) apolipoprotein E (APOE) epsilon3/epsilon2/epsilon4, cholesteryl ester transfer protein (CETP) TaqIB, and apolipoprotein C3 (APOC3) -482 C>T have been associated with an atherogenic lipid profile and, in some studies, with increased cardiovascular risk. However, no data exist on their combined impact on atherosclerotic disease. We therefore aimed at investigating the combined impact of these SNPs on the presence of angiographically determined coronary artery disease (CAD). Genotyping was performed in 557 consecutive Caucasian patients undergoing coronary angiography for the evaluation of CAD. From the individual SNPs, only the APOE epsilon3epsilon4/epsilon4epsilon4 genotype was significantly associated with an increased risk of significant coronary stenoses with lumen narrowing >or=50% (odds ratio (OR)=1.77 [1.16-2.71]; p=0.008). However, the risk of CAD strongly increased when more than one of the analysed genetic variants was present: ORs were 2.74 [1.29-5.83]; p=0.009 for patients with both the APOE epsilon3epsilon4/epsilon4epsilon4 and the CETP B1B1 genotype, 1.97 [1.06-3.66]; p=0.031 for patients with both the APOE epsilon3epsilon4/epsilon4epsilon4 genotype and the APOC3 -482T allele, 2.12 [1.31-3.44]; p=0.002 for patients with both the CETP B1B1 genotype and the APOC3 -482T allele, and 3.99 [1.57-13.79]; p=0.029 for patients with all three variants. Multivariate analyses confirmed these results. We conclude that there are strong synergistic effects of the APOE epsilon3/epsilon2/epsilon4, the CETP TaqIB, and the APOC3 -482 C>T polymorphisms on their association with CAD. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/18289550/Synergistic_effects_of_the_apolipoprotein_E_epsilon3/epsilon2/epsilon4_the_cholesteryl_ester_transfer_protein_TaqIB_and_the_apolipoprotein_C3__482_C>T_polymorphisms_on_their_association_with_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(07)00684-3 DB - PRIME DP - Unbound Medicine ER -