Tags

Type your tag names separated by a space and hit enter

Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry.
Neuropsychologia 2008; 46(6):1721-31N

Abstract

The hippocampus is the brain structure of highest and earliest structural alteration in Alzheimer's disease (AD). New developments in neuroimaging methods recently made it possible to assess the respective involvement of the different hippocampal subfields by mapping atrophy on a 3D hippocampal surface view. In this longitudinal study on patients with mild cognitive impairment (MCI), we used such an approach to map the profile of hippocampal atrophy and its progression over an 18-month follow-up period in rapid converters to AD and "non-converters" compared to age-matched controls. For the sake of comparison, we also assessed the profile of hippocampal atrophy associated with AD and with increasing age in a healthy control population ranging from young adult to elderly. We found major involvement of the lateral part of the superior hippocampus mainly corresponding to the CA1 subfield in MCI and AD while increasing age was mainly associated with subiculum atrophy in the healthy population. Moreover, the CA1 subfield also showed highest atrophy rates during follow-up, in both rapid converters and "non-converters" although increased effects were observed in the former group. This study emphasizes the differences between normal aging and AD processes leading to hippocampal atrophy, pointing to a specific AD-related CA1 involvement while subiculum atrophy would represent a normal aging process. Our findings also suggest that the degree of hippocampal atrophy, more than its spatial localization, predicts rapid conversion to AD in patients with MCI.

Authors+Show Affiliations

Inserm-EPHE-Université de Caen Basse-Normandie, Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France. chetelat@cyceron.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18289618

Citation

Chételat, G, et al. "Three-dimensional Surface Mapping of Hippocampal Atrophy Progression From MCI to AD and Over Normal Aging as Assessed Using Voxel-based Morphometry." Neuropsychologia, vol. 46, no. 6, 2008, pp. 1721-31.
Chételat G, Fouquet M, Kalpouzos G, et al. Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry. Neuropsychologia. 2008;46(6):1721-31.
Chételat, G., Fouquet, M., Kalpouzos, G., Denghien, I., De la Sayette, V., Viader, F., ... Desgranges, B. (2008). Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry. Neuropsychologia, 46(6), pp. 1721-31. doi:10.1016/j.neuropsychologia.2007.11.037.
Chételat G, et al. Three-dimensional Surface Mapping of Hippocampal Atrophy Progression From MCI to AD and Over Normal Aging as Assessed Using Voxel-based Morphometry. Neuropsychologia. 2008;46(6):1721-31. PubMed PMID: 18289618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry. AU - Chételat,G, AU - Fouquet,M, AU - Kalpouzos,G, AU - Denghien,I, AU - De la Sayette,V, AU - Viader,F, AU - Mézenge,F, AU - Landeau,B, AU - Baron,J C, AU - Eustache,F, AU - Desgranges,B, Y1 - 2008/01/16/ PY - 2007/07/24/received PY - 2007/10/04/revised PY - 2007/11/30/accepted PY - 2008/2/22/pubmed PY - 2008/9/25/medline PY - 2008/2/22/entrez SP - 1721 EP - 31 JF - Neuropsychologia JO - Neuropsychologia VL - 46 IS - 6 N2 - The hippocampus is the brain structure of highest and earliest structural alteration in Alzheimer's disease (AD). New developments in neuroimaging methods recently made it possible to assess the respective involvement of the different hippocampal subfields by mapping atrophy on a 3D hippocampal surface view. In this longitudinal study on patients with mild cognitive impairment (MCI), we used such an approach to map the profile of hippocampal atrophy and its progression over an 18-month follow-up period in rapid converters to AD and "non-converters" compared to age-matched controls. For the sake of comparison, we also assessed the profile of hippocampal atrophy associated with AD and with increasing age in a healthy control population ranging from young adult to elderly. We found major involvement of the lateral part of the superior hippocampus mainly corresponding to the CA1 subfield in MCI and AD while increasing age was mainly associated with subiculum atrophy in the healthy population. Moreover, the CA1 subfield also showed highest atrophy rates during follow-up, in both rapid converters and "non-converters" although increased effects were observed in the former group. This study emphasizes the differences between normal aging and AD processes leading to hippocampal atrophy, pointing to a specific AD-related CA1 involvement while subiculum atrophy would represent a normal aging process. Our findings also suggest that the degree of hippocampal atrophy, more than its spatial localization, predicts rapid conversion to AD in patients with MCI. SN - 0028-3932 UR - https://www.unboundmedicine.com/medline/citation/18289618/Three_dimensional_surface_mapping_of_hippocampal_atrophy_progression_from_MCI_to_AD_and_over_normal_aging_as_assessed_using_voxel_based_morphometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(07)00456-3 DB - PRIME DP - Unbound Medicine ER -