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Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up.
J Affect Disord. 2008 Aug; 109(3):286-99.JA

Abstract

OBJECTIVE

Many studies have reported that cognitive ability may be predictive of the functional outcome for patients with schizophrenia. However, no study has prospectively examined these aspects in schizophrenia and bipolar disorders simultaneously. The present study attempted to analyze if neurocognition and clinical status predicts the real-life functioning for patients with schizophrenia or bipolar I disorder, using a longitudinal design.

METHOD

Forty-seven schizophrenic and 43 bipolar I outpatients were assessed twice with a neurocognitive battery (Executive Functions, Working Memory, Verbal Memory, Visual Memory, Visual-Motor Processing, Vigilance, Vocabulary and Motor Speed tasks), clinical scales (the Positive and Negative Symptom Scale, the Hamilton Rating Scale for Depression and the Clinician Administered Rating Scale for Mania) and functional outcome measures (the Global Assessment of Functioning Scale, the WHO's Disability Assessment Scale and occupational adaptation level) over a one-year follow-up period. The cognitive performance of the patients was compared, at baseline and one year later, with that of 25 healthy subjects.

RESULTS

In schizophrenia patients, global functioning one year later was predicted by a composite neurocognitive score and three specific domain (verbal memory, motor speed, vocabulary). Symptoms appeared to explain less of the variance in functioning. In bipolar I patients, changes in the composite neurocognitive score over one year, deficits in the visual/motor processing domain, severity of symptoms (psychotic, excitatory and affective symptoms) and premorbid adjustment at the first assessment were the variables that better predicted functioning or disability changes over follow-up period.

CONCLUSIONS

Although the relationships between cognition, symptoms and functional capacity differ for schizophrenia or bipolar I patients, neuropsychological performance seems to be a principal longitudinal predictor of functioning in both disorders. Baseline neurocognition and cognitive changes over 12 months predicted changes in functioning over the same period, but only in bipolar I patients. These cognitive domains could be potential neurocognitive endophenotypes (endophenocognitypes) with regard to bipolar I disorder.

Authors+Show Affiliations

The Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Valencia, Spain. Rafael.Tabares@uv.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18289698

Citation

Tabarés-Seisdedos, Rafael, et al. "Neurocognitive and Clinical Predictors of Functional Outcome in Patients With Schizophrenia and Bipolar I Disorder at One-year Follow-up." Journal of Affective Disorders, vol. 109, no. 3, 2008, pp. 286-99.
Tabarés-Seisdedos R, Balanzá-Martínez V, Sánchez-Moreno J, et al. Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. J Affect Disord. 2008;109(3):286-99.
Tabarés-Seisdedos, R., Balanzá-Martínez, V., Sánchez-Moreno, J., Martinez-Aran, A., Salazar-Fraile, J., Selva-Vera, G., Rubio, C., Mata, I., Gómez-Beneyto, M., & Vieta, E. (2008). Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. Journal of Affective Disorders, 109(3), 286-99. https://doi.org/10.1016/j.jad.2007.12.234
Tabarés-Seisdedos R, et al. Neurocognitive and Clinical Predictors of Functional Outcome in Patients With Schizophrenia and Bipolar I Disorder at One-year Follow-up. J Affect Disord. 2008;109(3):286-99. PubMed PMID: 18289698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. AU - Tabarés-Seisdedos,Rafael, AU - Balanzá-Martínez,Vicente, AU - Sánchez-Moreno,José, AU - Martinez-Aran,Anabel, AU - Salazar-Fraile,José, AU - Selva-Vera,Gabriel, AU - Rubio,Cristina, AU - Mata,Ignacio, AU - Gómez-Beneyto,Manuel, AU - Vieta,Eduard, Y1 - 2008/03/04/ PY - 2007/07/08/received PY - 2007/12/24/revised PY - 2007/12/24/accepted PY - 2008/2/22/pubmed PY - 2008/12/17/medline PY - 2008/2/22/entrez SP - 286 EP - 99 JF - Journal of affective disorders JO - J Affect Disord VL - 109 IS - 3 N2 - OBJECTIVE: Many studies have reported that cognitive ability may be predictive of the functional outcome for patients with schizophrenia. However, no study has prospectively examined these aspects in schizophrenia and bipolar disorders simultaneously. The present study attempted to analyze if neurocognition and clinical status predicts the real-life functioning for patients with schizophrenia or bipolar I disorder, using a longitudinal design. METHOD: Forty-seven schizophrenic and 43 bipolar I outpatients were assessed twice with a neurocognitive battery (Executive Functions, Working Memory, Verbal Memory, Visual Memory, Visual-Motor Processing, Vigilance, Vocabulary and Motor Speed tasks), clinical scales (the Positive and Negative Symptom Scale, the Hamilton Rating Scale for Depression and the Clinician Administered Rating Scale for Mania) and functional outcome measures (the Global Assessment of Functioning Scale, the WHO's Disability Assessment Scale and occupational adaptation level) over a one-year follow-up period. The cognitive performance of the patients was compared, at baseline and one year later, with that of 25 healthy subjects. RESULTS: In schizophrenia patients, global functioning one year later was predicted by a composite neurocognitive score and three specific domain (verbal memory, motor speed, vocabulary). Symptoms appeared to explain less of the variance in functioning. In bipolar I patients, changes in the composite neurocognitive score over one year, deficits in the visual/motor processing domain, severity of symptoms (psychotic, excitatory and affective symptoms) and premorbid adjustment at the first assessment were the variables that better predicted functioning or disability changes over follow-up period. CONCLUSIONS: Although the relationships between cognition, symptoms and functional capacity differ for schizophrenia or bipolar I patients, neuropsychological performance seems to be a principal longitudinal predictor of functioning in both disorders. Baseline neurocognition and cognitive changes over 12 months predicted changes in functioning over the same period, but only in bipolar I patients. These cognitive domains could be potential neurocognitive endophenotypes (endophenocognitypes) with regard to bipolar I disorder. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/18289698/Neurocognitive_and_clinical_predictors_of_functional_outcome_in_patients_with_schizophrenia_and_bipolar_I_disorder_at_one_year_follow_up_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(08)00015-3 DB - PRIME DP - Unbound Medicine ER -