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Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats.
Food Chem Toxicol. 2008 May; 46(5):1627-34.FC

Abstract

Alcoholic liver disease is a major medical complication of drinking alcohol. Oxidative stress plays an important role in the development of alcohol liver disease. The present study was carried to evaluate the effect of grape leaf extract (GLEt) on antioxidant and lipid peroxidation states in liver and kidney alcohol induced toxicity. In vitro studies with DPPH* and ABTS*(+) (cation radical) showed that GLEt possesses antioxidant activity. In vivo administration of ethanol (7.9 g/kg bw/day) for 45 days resulted an activity of liver marker enzymes (AST, ALT, ALP and GGT), lipid peroxidation markers (TBARS, lipid hydroperoxides) in liver and kidney with significantly lower activity of SOD, CAT, GPx, GST and non-enzymatic antioxidants (vitamin E, vitamin C and GSH) in liver and kidney as compared with control rats. Administration of ethanol along with GLEt significantly decreased the activities of liver markers enzyme in serum towards near normal level. GLEt at a dose of 100 mg/kg was highly effective than 25 and 50 mg/kg body weight. In addition GLEt also significantly reduced the levels of lipid peroxidation and addition, significantly restored the enzymic and non-enzymatic antioxidants level in liver and kidney of alcohol administration rats. This observation was supplemented by histopathological examination in liver and kidney. Our data suggest that GLEt exerts its protective effect by decreased the lipid peroxidation and improving antioxidants status, thus proving itself as an effective antioxidant in alcohol induced oxidative damage in rats.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India. paribalaji@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18289759

Citation

Pari, Leelavinothan, and Arumugam Suresh. "Effect of Grape (Vitis Vinifera L.) Leaf Extract On Alcohol Induced Oxidative Stress in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 5, 2008, pp. 1627-34.
Pari L, Suresh A. Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats. Food Chem Toxicol. 2008;46(5):1627-34.
Pari, L., & Suresh, A. (2008). Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(5), 1627-34. https://doi.org/10.1016/j.fct.2008.01.003
Pari L, Suresh A. Effect of Grape (Vitis Vinifera L.) Leaf Extract On Alcohol Induced Oxidative Stress in Rats. Food Chem Toxicol. 2008;46(5):1627-34. PubMed PMID: 18289759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats. AU - Pari,Leelavinothan, AU - Suresh,Arumugam, Y1 - 2008/01/08/ PY - 2007/02/20/received PY - 2007/12/20/revised PY - 2008/01/02/accepted PY - 2008/2/22/pubmed PY - 2008/6/6/medline PY - 2008/2/22/entrez SP - 1627 EP - 34 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 46 IS - 5 N2 - Alcoholic liver disease is a major medical complication of drinking alcohol. Oxidative stress plays an important role in the development of alcohol liver disease. The present study was carried to evaluate the effect of grape leaf extract (GLEt) on antioxidant and lipid peroxidation states in liver and kidney alcohol induced toxicity. In vitro studies with DPPH* and ABTS*(+) (cation radical) showed that GLEt possesses antioxidant activity. In vivo administration of ethanol (7.9 g/kg bw/day) for 45 days resulted an activity of liver marker enzymes (AST, ALT, ALP and GGT), lipid peroxidation markers (TBARS, lipid hydroperoxides) in liver and kidney with significantly lower activity of SOD, CAT, GPx, GST and non-enzymatic antioxidants (vitamin E, vitamin C and GSH) in liver and kidney as compared with control rats. Administration of ethanol along with GLEt significantly decreased the activities of liver markers enzyme in serum towards near normal level. GLEt at a dose of 100 mg/kg was highly effective than 25 and 50 mg/kg body weight. In addition GLEt also significantly reduced the levels of lipid peroxidation and addition, significantly restored the enzymic and non-enzymatic antioxidants level in liver and kidney of alcohol administration rats. This observation was supplemented by histopathological examination in liver and kidney. Our data suggest that GLEt exerts its protective effect by decreased the lipid peroxidation and improving antioxidants status, thus proving itself as an effective antioxidant in alcohol induced oxidative damage in rats. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18289759/Effect_of_grape__Vitis_vinifera_L___leaf_extract_on_alcohol_induced_oxidative_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00009-4 DB - PRIME DP - Unbound Medicine ER -