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Relationship between mean blood glucose and glycated haemoglobin in Type 2 diabetic patients.
Diabet Med. 2008 Feb; 25(2):174-8.DM

Abstract

AIMS

To correlate the values of MBG to HbA(1c) in Greek patients with Type 2 diabetes and/or metabolic syndrome.

METHODS

We followed up 140 Greek adult patients: 92 patients with Type 2 diabetes treated with insulin or oral glucose-lowering medication, and 48 patients with newly diagnosed Type 2 diabetes or metabolic syndrome not receiving any treatment. MBG was calculated for each patient from self-measurements of blood glucose using a portable glucometer, made six times a day (before eating and 2 h after a meal), three times a week for 1 month. HbA(1c) was determined by HPLC at 0 and 12 weeks.

RESULTS

HbA(1c) at 0 (x) and 12 weeks (y) correlated strongly (y = 0.790x + 1.115, r = 0.92), confirming that the patient's glycaemic status remained stable during the whole period of follow-up. Linear regression was performed on MBG values; HbA(1c) at 12 weeks, sex, age, body mass index (BMI) and patient status (Type 2 diabetes treated or not) were used as independent variables. None of the independent variables reached statistical significance in the model, with the exception of HbA(1c) at 12 weeks. The final model was: MBG (mg/dl) = (34.74 x HbA(1c)) - 79.21, r = 0.93; or MBG (mmol/l) = 1.91 x HbA(1c) - 4.36, r = 0.93.

CONCLUSIONS

Our results establish for the first time a strong correlation between MBG and HbA(1c) in Type 2 diabetic patients and support the idea of expressing HbA(1c) results as MBG. This will help patients to gain a clearer interpretation of the result, with less confusion. This simplification will allow every person with diabetes using home glucose-monitoring to understand his or her own target level.

Authors+Show Affiliations

Clinical Biochemistry Department, KAT General Hospital, Kifissia, Greece. knmakris@hol.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18290858

Citation

Makris, K, et al. "Relationship Between Mean Blood Glucose and Glycated Haemoglobin in Type 2 Diabetic Patients." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 25, no. 2, 2008, pp. 174-8.
Makris K, Spanou L, Rambaouni-Antoneli A, et al. Relationship between mean blood glucose and glycated haemoglobin in Type 2 diabetic patients. Diabet Med. 2008;25(2):174-8.
Makris, K., Spanou, L., Rambaouni-Antoneli, A., Koniari, K., Drakopoulos, I., Rizos, D., & Haliassos, A. (2008). Relationship between mean blood glucose and glycated haemoglobin in Type 2 diabetic patients. Diabetic Medicine : a Journal of the British Diabetic Association, 25(2), 174-8. https://doi.org/10.1111/j.1464-5491.2007.02379.x
Makris K, et al. Relationship Between Mean Blood Glucose and Glycated Haemoglobin in Type 2 Diabetic Patients. Diabet Med. 2008;25(2):174-8. PubMed PMID: 18290858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between mean blood glucose and glycated haemoglobin in Type 2 diabetic patients. AU - Makris,K, AU - Spanou,L, AU - Rambaouni-Antoneli,A, AU - Koniari,K, AU - Drakopoulos,I, AU - Rizos,D, AU - Haliassos,A, PY - 2008/2/23/pubmed PY - 2008/4/12/medline PY - 2008/2/23/entrez SP - 174 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 25 IS - 2 N2 - AIMS: To correlate the values of MBG to HbA(1c) in Greek patients with Type 2 diabetes and/or metabolic syndrome. METHODS: We followed up 140 Greek adult patients: 92 patients with Type 2 diabetes treated with insulin or oral glucose-lowering medication, and 48 patients with newly diagnosed Type 2 diabetes or metabolic syndrome not receiving any treatment. MBG was calculated for each patient from self-measurements of blood glucose using a portable glucometer, made six times a day (before eating and 2 h after a meal), three times a week for 1 month. HbA(1c) was determined by HPLC at 0 and 12 weeks. RESULTS: HbA(1c) at 0 (x) and 12 weeks (y) correlated strongly (y = 0.790x + 1.115, r = 0.92), confirming that the patient's glycaemic status remained stable during the whole period of follow-up. Linear regression was performed on MBG values; HbA(1c) at 12 weeks, sex, age, body mass index (BMI) and patient status (Type 2 diabetes treated or not) were used as independent variables. None of the independent variables reached statistical significance in the model, with the exception of HbA(1c) at 12 weeks. The final model was: MBG (mg/dl) = (34.74 x HbA(1c)) - 79.21, r = 0.93; or MBG (mmol/l) = 1.91 x HbA(1c) - 4.36, r = 0.93. CONCLUSIONS: Our results establish for the first time a strong correlation between MBG and HbA(1c) in Type 2 diabetic patients and support the idea of expressing HbA(1c) results as MBG. This will help patients to gain a clearer interpretation of the result, with less confusion. This simplification will allow every person with diabetes using home glucose-monitoring to understand his or her own target level. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/18290858/Relationship_between_mean_blood_glucose_and_glycated_haemoglobin_in_Type_2_diabetic_patients_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02379.x DB - PRIME DP - Unbound Medicine ER -