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Anti-Müllerian hormone and inhibin B as predictors of pregnancy after treatment by in vitro fertilization/intracytoplasmic sperm injection.
Fertil Steril. 2008 Dec; 90(6):2203-10.FS

Abstract

OBJECTIVE

To evaluate anti-Müllerian hormone (AMH) as a marker of reproductive outcome after IVF/intracytoplasmic sperm injection (ICSI).

DESIGN

Longitudinal study.

SETTING

University hospital.

PATIENT(S)

Two hundred seventy-six consecutive women undergoing IVF/ICSI.

INTERVENTION(S)

Ovarian stimulation, oocyte retrieval, IVF, ICSI, embryo transfer, AMH, and inhibin B determinations in serum and follicular fluid (FF).

MAIN OUTCOME MEASURE(S)

The AMH and inhibin B concentrations in 276 matched FF/serum pairs have been determined. Different outcome groups have been compared and set in relation to the oocyte count, morphological parameters, and steroid hormone levels.

RESULT(S)

The concentrations of AMH and inhibin B in both serum and FF were significantly higher in the group of women who became pregnant in the corresponding treatment cycle than in those who did not conceive. Positive correlations were observed between serum inhibin B concentrations and embryo morphology (r = 0.126, 95% confidence interval 0.026-0.284). Serum and FF AMH or inhibin B correlated positively with the oocyte count and negatively with the pretreatment cycle day 3 FSH level and the total administered gonadotropin dose.

CONCLUSION(S)

The AMH and inhibin B levels on the day of oocyte retrieval are correlated to reproductive outcome.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland. dorothea.wunder@insel.chNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18291376

Citation

Wunder, Dorothea M., et al. "Anti-Müllerian Hormone and Inhibin B as Predictors of Pregnancy After Treatment By in Vitro Fertilization/intracytoplasmic Sperm Injection." Fertility and Sterility, vol. 90, no. 6, 2008, pp. 2203-10.
Wunder DM, Guibourdenche J, Birkhäuser MH, et al. Anti-Müllerian hormone and inhibin B as predictors of pregnancy after treatment by in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril. 2008;90(6):2203-10.
Wunder, D. M., Guibourdenche, J., Birkhäuser, M. H., & Bersinger, N. A. (2008). Anti-Müllerian hormone and inhibin B as predictors of pregnancy after treatment by in vitro fertilization/intracytoplasmic sperm injection. Fertility and Sterility, 90(6), 2203-10. https://doi.org/10.1016/j.fertnstert.2007.10.078
Wunder DM, et al. Anti-Müllerian Hormone and Inhibin B as Predictors of Pregnancy After Treatment By in Vitro Fertilization/intracytoplasmic Sperm Injection. Fertil Steril. 2008;90(6):2203-10. PubMed PMID: 18291376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-Müllerian hormone and inhibin B as predictors of pregnancy after treatment by in vitro fertilization/intracytoplasmic sperm injection. AU - Wunder,Dorothea M, AU - Guibourdenche,Jean, AU - Birkhäuser,Martin H, AU - Bersinger,Nick A, Y1 - 2008/02/21/ PY - 2007/05/15/received PY - 2007/10/10/revised PY - 2007/10/30/accepted PY - 2008/2/23/pubmed PY - 2008/12/24/medline PY - 2008/2/23/entrez SP - 2203 EP - 10 JF - Fertility and sterility JO - Fertil Steril VL - 90 IS - 6 N2 - OBJECTIVE: To evaluate anti-Müllerian hormone (AMH) as a marker of reproductive outcome after IVF/intracytoplasmic sperm injection (ICSI). DESIGN: Longitudinal study. SETTING: University hospital. PATIENT(S): Two hundred seventy-six consecutive women undergoing IVF/ICSI. INTERVENTION(S): Ovarian stimulation, oocyte retrieval, IVF, ICSI, embryo transfer, AMH, and inhibin B determinations in serum and follicular fluid (FF). MAIN OUTCOME MEASURE(S): The AMH and inhibin B concentrations in 276 matched FF/serum pairs have been determined. Different outcome groups have been compared and set in relation to the oocyte count, morphological parameters, and steroid hormone levels. RESULT(S): The concentrations of AMH and inhibin B in both serum and FF were significantly higher in the group of women who became pregnant in the corresponding treatment cycle than in those who did not conceive. Positive correlations were observed between serum inhibin B concentrations and embryo morphology (r = 0.126, 95% confidence interval 0.026-0.284). Serum and FF AMH or inhibin B correlated positively with the oocyte count and negatively with the pretreatment cycle day 3 FSH level and the total administered gonadotropin dose. CONCLUSION(S): The AMH and inhibin B levels on the day of oocyte retrieval are correlated to reproductive outcome. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18291376/Anti_Müllerian_hormone_and_inhibin_B_as_predictors_of_pregnancy_after_treatment_by_in_vitro_fertilization/intracytoplasmic_sperm_injection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)03964-7 DB - PRIME DP - Unbound Medicine ER -