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Spectral entropy predicts auditory recall in volunteers.
Anesth Analg. 2008 Mar; 106(3):873-9, table of contents.A&A

Abstract

BACKGROUND

From a patient's perspective, intraoperative amnesia is an essential component of general anesthesia. Without specific strategies to reduce recall, its incidence is approximately 0.2% in the general surgical population and may be higher in certain subpopulations. We sought to test the validity for predicting recall of a new spectral entropy-based clinical electroencephalogram monitor.

METHODS

We studied 16 volunteers in an unblinded crossover design to assess the correlation of entropy values with behavioral end points during sedation with either propofol or sevoflurane. The end points we considered included word recall, and motor response to verbal command. We also examined the stimulatory effect of verbal commands on electroencephalogram entropy. Logistic regression, receiver operating characteristics, and prediction probability were used to analyze the data.

RESULTS

Both State Entropy and Response Entropy were closely correlated with both behavioral end points. The prediction probability of these parameters under a variety of conditions ranged from 0.85 to 0.96. Verbal command to move increased entropy in a dose and drug-dependent fashion.

CONCLUSIONS

Entropy parameters in this group of young, healthy volunteers appear to be reliable predictors of recall. These results justify extending these studies to additional anesthetics and to surgical patients.

Authors+Show Affiliations

Department of Anesthesiology, University Hospital, 100 East Loop Road, Stony Brook, NY 11794-8480, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18292433

Citation

Moller, Daryn H., and Ira J. Rampil. "Spectral Entropy Predicts Auditory Recall in Volunteers." Anesthesia and Analgesia, vol. 106, no. 3, 2008, 873-9, table of contents.
Moller DH, Rampil IJ. Spectral entropy predicts auditory recall in volunteers. Anesth Analg. 2008;106(3):873-9, table of contents.
Moller, D. H., & Rampil, I. J. (2008). Spectral entropy predicts auditory recall in volunteers. Anesthesia and Analgesia, 106(3), 873-9, table of contents. https://doi.org/10.1213/ane.0b013e318163201d
Moller DH, Rampil IJ. Spectral Entropy Predicts Auditory Recall in Volunteers. Anesth Analg. 2008;106(3):873-9, table of contents. PubMed PMID: 18292433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectral entropy predicts auditory recall in volunteers. AU - Moller,Daryn H, AU - Rampil,Ira J, PY - 2008/2/23/pubmed PY - 2008/3/12/medline PY - 2008/2/23/entrez SP - 873-9, table of contents JF - Anesthesia and analgesia JO - Anesth Analg VL - 106 IS - 3 N2 - BACKGROUND: From a patient's perspective, intraoperative amnesia is an essential component of general anesthesia. Without specific strategies to reduce recall, its incidence is approximately 0.2% in the general surgical population and may be higher in certain subpopulations. We sought to test the validity for predicting recall of a new spectral entropy-based clinical electroencephalogram monitor. METHODS: We studied 16 volunteers in an unblinded crossover design to assess the correlation of entropy values with behavioral end points during sedation with either propofol or sevoflurane. The end points we considered included word recall, and motor response to verbal command. We also examined the stimulatory effect of verbal commands on electroencephalogram entropy. Logistic regression, receiver operating characteristics, and prediction probability were used to analyze the data. RESULTS: Both State Entropy and Response Entropy were closely correlated with both behavioral end points. The prediction probability of these parameters under a variety of conditions ranged from 0.85 to 0.96. Verbal command to move increased entropy in a dose and drug-dependent fashion. CONCLUSIONS: Entropy parameters in this group of young, healthy volunteers appear to be reliable predictors of recall. These results justify extending these studies to additional anesthetics and to surgical patients. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/18292433/Spectral_entropy_predicts_auditory_recall_in_volunteers_ L2 - https://doi.org/10.1213/ane.0b013e318163201d DB - PRIME DP - Unbound Medicine ER -