Tags

Type your tag names separated by a space and hit enter

Cirrhotic cardiomyopathy.
Semin Liver Dis. 2008 Feb; 28(1):59-69.SL

Abstract

Liver cirrhosis is associated with several cardiovascular abnormalities. Despite an increased baseline cardiac output, cirrhotic patients have a suboptimal ventricular response to stress. This phenomenon is called cirrhotic cardiomyopathy. The pathogenesis of this syndrome is multifactorial and includes diminished beta-adrenergic receptor signal transduction, cardiomyocyte cellular plasma membrane dysfunction, and increased activity or levels of cardiodepressant substances such as cytokines, endogenous cannabinoids, and nitric oxide. Although cirrhotic cardiomyopathy is usually clinically mild or silent, overt heart failure can be precipitated by stresses such as liver transplantation or transjugular intrahepatic portosystemic shunt insertion. Moreover, cirrhotic cardiomyopathy may play a role in the pathogenesis of hepatorenal syndrome. Treatment of this condition is mainly supportive. Orthotopic liver transplantation appears to improve or normalize the condition, generally after a period of several months.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Alqahtani SA
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Fouad TR
No affiliation info available
Lee SS
No affiliation info available

MeSH

CardiomyopathiesElectrocardiographyHumansLiver CirrhosisLiver TransplantationMyocardial ContractionPortasystemic Shunt, Transjugular IntrahepaticPrognosis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18293277

Citation

Alqahtani, Saleh A., et al. "Cirrhotic Cardiomyopathy." Seminars in Liver Disease, vol. 28, no. 1, 2008, pp. 59-69.
Alqahtani SA, Fouad TR, Lee SS. Cirrhotic cardiomyopathy. Semin Liver Dis. 2008;28(1):59-69.
Alqahtani, S. A., Fouad, T. R., & Lee, S. S. (2008). Cirrhotic cardiomyopathy. Seminars in Liver Disease, 28(1), 59-69. https://doi.org/10.1055/s-2008-1040321
Alqahtani SA, Fouad TR, Lee SS. Cirrhotic Cardiomyopathy. Semin Liver Dis. 2008;28(1):59-69. PubMed PMID: 18293277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cirrhotic cardiomyopathy. AU - Alqahtani,Saleh A, AU - Fouad,Tamer R, AU - Lee,Samuel S, PY - 2008/2/23/pubmed PY - 2008/7/11/medline PY - 2008/2/23/entrez SP - 59 EP - 69 JF - Seminars in liver disease JO - Semin Liver Dis VL - 28 IS - 1 N2 - Liver cirrhosis is associated with several cardiovascular abnormalities. Despite an increased baseline cardiac output, cirrhotic patients have a suboptimal ventricular response to stress. This phenomenon is called cirrhotic cardiomyopathy. The pathogenesis of this syndrome is multifactorial and includes diminished beta-adrenergic receptor signal transduction, cardiomyocyte cellular plasma membrane dysfunction, and increased activity or levels of cardiodepressant substances such as cytokines, endogenous cannabinoids, and nitric oxide. Although cirrhotic cardiomyopathy is usually clinically mild or silent, overt heart failure can be precipitated by stresses such as liver transplantation or transjugular intrahepatic portosystemic shunt insertion. Moreover, cirrhotic cardiomyopathy may play a role in the pathogenesis of hepatorenal syndrome. Treatment of this condition is mainly supportive. Orthotopic liver transplantation appears to improve or normalize the condition, generally after a period of several months. SN - 0272-8087 UR - https://www.unboundmedicine.com/medline/citation/18293277/Cirrhotic_cardiomyopathy_ DB - PRIME DP - Unbound Medicine ER -