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Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship.
J Med Chem. 2008 Apr 10; 51(7):2307-10.JM

Abstract

A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Boumendjel A
Département de Pharmacochimie Moléculaire, UMR 5063, ICMG-FR 2607-Université Joseph Fourier Grenoble I, 470 rue de la Chimie, 38240 St Martin d'Hères, France. ahcene.boumendjel@ujf-grenoble.fr
Boccard J
No affiliation info available
Carrupt PA
No affiliation info available
Nicolle E
No affiliation info available
Blanc M
No affiliation info available
Geze A
No affiliation info available
Choisnard L
No affiliation info available
Wouessidjewe D
No affiliation info available
Matera EL
No affiliation info available
Dumontet C
No affiliation info available

MeSH

AnimalsAntimitotic AgentsAntineoplastic AgentsCell CycleCell Line, TumorCell ProliferationCell SurvivalChalconesDrug Screening Assays, AntitumorDrug-Related Side Effects and Adverse ReactionsHumansMiceMolecular StructureStereoisomerismStructure-Activity RelationshipSurvival Rate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18293907

Citation

Boumendjel, Ahcène, et al. "Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure-activity Relationship." Journal of Medicinal Chemistry, vol. 51, no. 7, 2008, pp. 2307-10.
Boumendjel A, Boccard J, Carrupt PA, et al. Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. J Med Chem. 2008;51(7):2307-10.
Boumendjel, A., Boccard, J., Carrupt, P. A., Nicolle, E., Blanc, M., Geze, A., Choisnard, L., Wouessidjewe, D., Matera, E. L., & Dumontet, C. (2008). Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. Journal of Medicinal Chemistry, 51(7), 2307-10. https://doi.org/10.1021/jm0708331
Boumendjel A, et al. Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure-activity Relationship. J Med Chem. 2008 Apr 10;51(7):2307-10. PubMed PMID: 18293907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. AU - Boumendjel,Ahcène, AU - Boccard,Julien, AU - Carrupt,Pierre-Alain, AU - Nicolle,Edwige, AU - Blanc,Madeleine, AU - Geze,Annabelle, AU - Choisnard,Luc, AU - Wouessidjewe,Denis, AU - Matera,Eva-Laure, AU - Dumontet,Charles, Y1 - 2008/02/23/ PY - 2008/2/26/pubmed PY - 2008/6/14/medline PY - 2008/2/26/entrez SP - 2307 EP - 10 JF - Journal of medicinal chemistry JO - J Med Chem VL - 51 IS - 7 N2 - A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation. SN - 0022-2623 UR - https://www.unboundmedicine.com/medline/citation/18293907/Antimitotic_and_antiproliferative_activities_of_chalcones:_forward_structure_activity_relationship_ DB - PRIME DP - Unbound Medicine ER -