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Metastatic ovarian carcinoma-associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the gamma 2 subunit of laminin 5 showing unusual clinical features.
Br J Dermatol. 2008 Jun; 158(6):1354-7.BJ

Abstract

Anti-p200 pemphigoid is an autoimmune subepidermal blistering disease characterized by autoantibodies to an unknown 200-kDa acidic noncollagenous glycoprotein of the lower lamina lucida, whereas antilaminin 5 mucous membrane pemphigoid is characterized by autoantibodies to a major basement membrane extracellular matrix, laminin 5. We report a 64-year-old Japanese woman with a subepidermal blistering disease associated with lymph node metastasis of ovarian clear cell carcinoma 10 years after its surgical treatment. Clinical features showed severe blisters and erosions on multiple mucous membranes (i.e. lip, oral cavity, nose, eye, genitalia and anus) and on both the periungual and subungual regions. This is the first report in which an immunoblot analysis revealed the unusual combination of autoantibodies to both the p200 antigen and the gamma 2 subunit of laminin 5.

Authors+Show Affiliations

Department of Dermatology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan. juniko@med.nihon-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18294311

Citation

Mitsuya, J, et al. "Metastatic Ovarian Carcinoma-associated Subepidermal Blistering Disease With Autoantibodies to Both the P200 Dermal Antigen and the Gamma 2 Subunit of Laminin 5 Showing Unusual Clinical Features." The British Journal of Dermatology, vol. 158, no. 6, 2008, pp. 1354-7.
Mitsuya J, Hara H, Ito K, et al. Metastatic ovarian carcinoma-associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the gamma 2 subunit of laminin 5 showing unusual clinical features. Br J Dermatol. 2008;158(6):1354-7.
Mitsuya, J., Hara, H., Ito, K., Ishii, N., Hashimoto, T., & Terui, T. (2008). Metastatic ovarian carcinoma-associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the gamma 2 subunit of laminin 5 showing unusual clinical features. The British Journal of Dermatology, 158(6), 1354-7. https://doi.org/10.1111/j.1365-2133.2008.08483.x
Mitsuya J, et al. Metastatic Ovarian Carcinoma-associated Subepidermal Blistering Disease With Autoantibodies to Both the P200 Dermal Antigen and the Gamma 2 Subunit of Laminin 5 Showing Unusual Clinical Features. Br J Dermatol. 2008;158(6):1354-7. PubMed PMID: 18294311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metastatic ovarian carcinoma-associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the gamma 2 subunit of laminin 5 showing unusual clinical features. AU - Mitsuya,J, AU - Hara,H, AU - Ito,K, AU - Ishii,N, AU - Hashimoto,T, AU - Terui,T, Y1 - 2008/02/22/ PY - 2008/2/26/pubmed PY - 2008/8/21/medline PY - 2008/2/26/entrez SP - 1354 EP - 7 JF - The British journal of dermatology JO - Br J Dermatol VL - 158 IS - 6 N2 - Anti-p200 pemphigoid is an autoimmune subepidermal blistering disease characterized by autoantibodies to an unknown 200-kDa acidic noncollagenous glycoprotein of the lower lamina lucida, whereas antilaminin 5 mucous membrane pemphigoid is characterized by autoantibodies to a major basement membrane extracellular matrix, laminin 5. We report a 64-year-old Japanese woman with a subepidermal blistering disease associated with lymph node metastasis of ovarian clear cell carcinoma 10 years after its surgical treatment. Clinical features showed severe blisters and erosions on multiple mucous membranes (i.e. lip, oral cavity, nose, eye, genitalia and anus) and on both the periungual and subungual regions. This is the first report in which an immunoblot analysis revealed the unusual combination of autoantibodies to both the p200 antigen and the gamma 2 subunit of laminin 5. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/18294311/Metastatic_ovarian_carcinoma_associated_subepidermal_blistering_disease_with_autoantibodies_to_both_the_p200_dermal_antigen_and_the_gamma_2_subunit_of_laminin_5_showing_unusual_clinical_features_ L2 - https://doi.org/10.1111/j.1365-2133.2008.08483.x DB - PRIME DP - Unbound Medicine ER -