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Matured human monocyte-derived dendritic cells (MoDCs) induce expansion of CD4+CD25+FOXP3+ T cells lacking regulatory properties.
Immunol Lett. 2008 Apr 15; 117(1):106-13.IL

Abstract

Naturally occurring CD4(+)CD25(+) T regulatory cells (nTregs) play a key role as suppressors in immune mechanisms that protect against self-destruction. The forkhead box p3 transcription factor (FOXP3) has a central role in the development of nTregs. We show here that co-culture of naïve T cells with flagellin-exposed monocyte-derived dendritic cells (MoDCs) generates CD4(+)CD25(+)FOXP3(+) T cells that transiently express FOXP3 together with CD25 but do not suppress proliferation of CD4(+)CD25(-) T cells. Moreover, purified CD4(+)CD25(+)FOXP3(+) T cells reveal a different proliferation and cytokine production profile from that of nTregs. These data indicate that in the presence of ongoing immune responses a T cell antigenic phenotype superimposable of that of nTregs does not necessarily predict suppressive function and that FOXP3 in humans is not sufficient for development and function of regulatory T cells.

Authors+Show Affiliations

Molecular Biology Unit, Department of Experimental Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy. Andrea.Merlo@istitutotumori.mi.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18295349

Citation

Merlo, Andrea, et al. "Matured Human Monocyte-derived Dendritic Cells (MoDCs) Induce Expansion of CD4+CD25+FOXP3+ T Cells Lacking Regulatory Properties." Immunology Letters, vol. 117, no. 1, 2008, pp. 106-13.
Merlo A, Tagliabue E, Mènard S, et al. Matured human monocyte-derived dendritic cells (MoDCs) induce expansion of CD4+CD25+FOXP3+ T cells lacking regulatory properties. Immunol Lett. 2008;117(1):106-13.
Merlo, A., Tagliabue, E., Mènard, S., & Balsari, A. (2008). Matured human monocyte-derived dendritic cells (MoDCs) induce expansion of CD4+CD25+FOXP3+ T cells lacking regulatory properties. Immunology Letters, 117(1), 106-13. https://doi.org/10.1016/j.imlet.2008.01.006
Merlo A, et al. Matured Human Monocyte-derived Dendritic Cells (MoDCs) Induce Expansion of CD4+CD25+FOXP3+ T Cells Lacking Regulatory Properties. Immunol Lett. 2008 Apr 15;117(1):106-13. PubMed PMID: 18295349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matured human monocyte-derived dendritic cells (MoDCs) induce expansion of CD4+CD25+FOXP3+ T cells lacking regulatory properties. AU - Merlo,Andrea, AU - Tagliabue,Elda, AU - Mènard,Sylvie, AU - Balsari,Andrea, Y1 - 2008/02/07/ PY - 2007/11/26/received PY - 2008/01/11/revised PY - 2008/01/14/accepted PY - 2008/2/26/pubmed PY - 2008/8/7/medline PY - 2008/2/26/entrez SP - 106 EP - 13 JF - Immunology letters JO - Immunol Lett VL - 117 IS - 1 N2 - Naturally occurring CD4(+)CD25(+) T regulatory cells (nTregs) play a key role as suppressors in immune mechanisms that protect against self-destruction. The forkhead box p3 transcription factor (FOXP3) has a central role in the development of nTregs. We show here that co-culture of naïve T cells with flagellin-exposed monocyte-derived dendritic cells (MoDCs) generates CD4(+)CD25(+)FOXP3(+) T cells that transiently express FOXP3 together with CD25 but do not suppress proliferation of CD4(+)CD25(-) T cells. Moreover, purified CD4(+)CD25(+)FOXP3(+) T cells reveal a different proliferation and cytokine production profile from that of nTregs. These data indicate that in the presence of ongoing immune responses a T cell antigenic phenotype superimposable of that of nTregs does not necessarily predict suppressive function and that FOXP3 in humans is not sufficient for development and function of regulatory T cells. SN - 0165-2478 UR - https://www.unboundmedicine.com/medline/citation/18295349/Matured_human_monocyte_derived_dendritic_cells__MoDCs__induce_expansion_of_CD4+CD25+FOXP3+_T_cells_lacking_regulatory_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-2478(08)00020-5 DB - PRIME DP - Unbound Medicine ER -