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The locus coeruleus involves in consolidation and memory retrieval, but not in acquisition of inhibitory avoidance learning task.
Behav Brain Res. 2008 Jun 03; 189(2):257-62.BB

Abstract

The locus coeruleus (LC) located at the level of the pons, is involved in cognitive functions such as learning and memory. The bilateral lidocaine-induced reversible inactivation of this nucleus has been considered in order to study its role in the phases of memory processing (acquisition, consolidation and retention) without any interference with the function of the same structure either during earlier and/or later phases of the same process. In this study, inhibitory avoidance (IA) learning task used to find the LC function in acquisition, consolidation and retrieval. Saline or lidocaine 4% (0.5 microl/side) microinjected into the LC, for assessing the acquisition (5 min before training), consolidation (5, 90 and 360 min after training) and memory retrieval, 5 min before testing. The retention test was done 24h after learning. Our results indicated that: (1) The bilateral functional inactivation of LC before training did not affect acquisition, but affected subsequent memory retention 24h later in IA task. (2) The lidocaine-induced inactivation of LC only 5 min after training impaired consolidation but did not affect it after 90 or 360 min. (3) Inactivation of the LC, 5 min before pre-retrieval test, impaired memory retrieval in IA task. In conclusion, it seems that the nucleus locus coeruleus does not affect acquisition while it involves in the memory consolidation and retrieval of inhibitory avoidance learning task.

Authors+Show Affiliations

Cellular & Molecular Research Center and Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18295357

Citation

Khakpour-Taleghani, Behrooz, et al. "The Locus Coeruleus Involves in Consolidation and Memory Retrieval, but Not in Acquisition of Inhibitory Avoidance Learning Task." Behavioural Brain Research, vol. 189, no. 2, 2008, pp. 257-62.
Khakpour-Taleghani B, Lashgari R, Aavani T, et al. The locus coeruleus involves in consolidation and memory retrieval, but not in acquisition of inhibitory avoidance learning task. Behav Brain Res. 2008;189(2):257-62.
Khakpour-Taleghani, B., Lashgari, R., Aavani, T., Haghparast, A., Naderi, N., & Motamedi, F. (2008). The locus coeruleus involves in consolidation and memory retrieval, but not in acquisition of inhibitory avoidance learning task. Behavioural Brain Research, 189(2), 257-62. https://doi.org/10.1016/j.bbr.2008.01.004
Khakpour-Taleghani B, et al. The Locus Coeruleus Involves in Consolidation and Memory Retrieval, but Not in Acquisition of Inhibitory Avoidance Learning Task. Behav Brain Res. 2008 Jun 3;189(2):257-62. PubMed PMID: 18295357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The locus coeruleus involves in consolidation and memory retrieval, but not in acquisition of inhibitory avoidance learning task. AU - Khakpour-Taleghani,Behrooz, AU - Lashgari,Reza, AU - Aavani,Tooka, AU - Haghparast,Abbas, AU - Naderi,Nima, AU - Motamedi,Fereshteh, Y1 - 2008/01/18/ PY - 2007/11/18/received PY - 2008/01/01/revised PY - 2008/01/03/accepted PY - 2008/2/26/pubmed PY - 2008/7/10/medline PY - 2008/2/26/entrez SP - 257 EP - 62 JF - Behavioural brain research JO - Behav Brain Res VL - 189 IS - 2 N2 - The locus coeruleus (LC) located at the level of the pons, is involved in cognitive functions such as learning and memory. The bilateral lidocaine-induced reversible inactivation of this nucleus has been considered in order to study its role in the phases of memory processing (acquisition, consolidation and retention) without any interference with the function of the same structure either during earlier and/or later phases of the same process. In this study, inhibitory avoidance (IA) learning task used to find the LC function in acquisition, consolidation and retrieval. Saline or lidocaine 4% (0.5 microl/side) microinjected into the LC, for assessing the acquisition (5 min before training), consolidation (5, 90 and 360 min after training) and memory retrieval, 5 min before testing. The retention test was done 24h after learning. Our results indicated that: (1) The bilateral functional inactivation of LC before training did not affect acquisition, but affected subsequent memory retention 24h later in IA task. (2) The lidocaine-induced inactivation of LC only 5 min after training impaired consolidation but did not affect it after 90 or 360 min. (3) Inactivation of the LC, 5 min before pre-retrieval test, impaired memory retrieval in IA task. In conclusion, it seems that the nucleus locus coeruleus does not affect acquisition while it involves in the memory consolidation and retrieval of inhibitory avoidance learning task. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/18295357/The_locus_coeruleus_involves_in_consolidation_and_memory_retrieval_but_not_in_acquisition_of_inhibitory_avoidance_learning_task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(08)00013-2 DB - PRIME DP - Unbound Medicine ER -