Tags

Type your tag names separated by a space and hit enter

Severe sepsis and septic shock in the emergency department.
Infect Dis Clin North Am. 2008 Mar; 22(1):1-31, v.ID

Abstract

Increased attention has focused recently on the acute management of severe sepsis and septic shock, conditions that represent the end-stage systemic deterioration of overwhelming infection. Clinical trials have identified new therapies and management approaches that, when applied early, appear to reduce mortality. Practice guidelines have been advanced by critical care societies, and many of the proposed interventions involve therapies other than antimicrobials directed at hemodynamic resuscitation or addressing adverse effects of the inflammatory cascade. Although many emergency departments (EDs) are now adopting treatment protocols for sepsis that are based on published treatment guidelines, recent research calls many of the initial recommendations into question, and validation trials of some of these approaches are ongoing. This article reviews the initial evaluation and treatment considerations of sepsis in the ED setting.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Talan DA
David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA. dtalan@ucla.edu
Moran GJ
No affiliation info available
Abrahamian FM
No affiliation info available

MeSH

Adrenal Cortex HormonesAnti-Infective AgentsEmergency MedicineEmergency Service, HospitalHemodynamicsHumansPractice Guidelines as TopicProtein CRandomized Controlled Trials as TopicSepsisShock, Septic

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18295681

Clinical Trial Links

Lotta Alla Sepsi Ospedaliera - Fighting Hospital Sepsis

Citation

Talan, David A., et al. "Severe Sepsis and Septic Shock in the Emergency Department." Infectious Disease Clinics of North America, vol. 22, no. 1, 2008, pp. 1-31, v.
Talan DA, Moran GJ, Abrahamian FM. Severe sepsis and septic shock in the emergency department. Infect Dis Clin North Am. 2008;22(1):1-31, v.
Talan, D. A., Moran, G. J., & Abrahamian, F. M. (2008). Severe sepsis and septic shock in the emergency department. Infectious Disease Clinics of North America, 22(1), 1-31, v. https://doi.org/10.1016/j.idc.2007.09.005
Talan DA, Moran GJ, Abrahamian FM. Severe Sepsis and Septic Shock in the Emergency Department. Infect Dis Clin North Am. 2008;22(1):1-31, v. PubMed PMID: 18295681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe sepsis and septic shock in the emergency department. AU - Talan,David A, AU - Moran,Gregory J, AU - Abrahamian,Fredrick M, PY - 2008/2/26/pubmed PY - 2008/5/6/medline PY - 2008/2/26/entrez SP - 1-31, v JF - Infectious disease clinics of North America JO - Infect Dis Clin North Am VL - 22 IS - 1 N2 - Increased attention has focused recently on the acute management of severe sepsis and septic shock, conditions that represent the end-stage systemic deterioration of overwhelming infection. Clinical trials have identified new therapies and management approaches that, when applied early, appear to reduce mortality. Practice guidelines have been advanced by critical care societies, and many of the proposed interventions involve therapies other than antimicrobials directed at hemodynamic resuscitation or addressing adverse effects of the inflammatory cascade. Although many emergency departments (EDs) are now adopting treatment protocols for sepsis that are based on published treatment guidelines, recent research calls many of the initial recommendations into question, and validation trials of some of these approaches are ongoing. This article reviews the initial evaluation and treatment considerations of sepsis in the ED setting. SN - 0891-5520 UR - https://www.unboundmedicine.com/medline/citation/18295681/Severe_sepsis_and_septic_shock_in_the_emergency_department_ DB - PRIME DP - Unbound Medicine ER -