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Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea.

Abstract

Menstrual pain (dysmenorrhea) is one of the main complaints in clinics for women. The pain is often accompanied by other symptoms such as headache, nausea, constipation or diarrhea, urinary frequency, and vomiting which often leave the patients incapacitated for work or school for a few days. Dietary supplementation with polyunsaturated fatty acids (PUFA) has been shown to alleviate the menstrual pain. The purpose of the present study was to compare the effect of dietary supplementation with PUFA (sunflower seed oil, borage oil and fish oil concentrate) for three months on RBC membrane fatty acid composition in healthy and dysmenorrheica young women. Conversion of linoleic acid, via gamma-linolenic acid, to dihomo-gamma-linolenic acid (a precursor of anti-inflammatory prostaglandin E1) in dysmenorrheic subjects as compared to the controls was slower whereas the level of arachidonic acid (a precursor of pro-inflammatory PGE2) was not affected by the supplementation. Since there are no known side-effects associated with supplementation of these nutrients, management of dysmenorrhea through nutrition modulation should be an acceptable alternative to drug treatments.

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  • Authors+Show Affiliations

    ,

    Department of Food Science and Biotechnology, National Chung Hsing University. 250 Kuo-Kuang Road, Taichung, Taiwan 402.

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    Source

    MeSH

    Adult
    Dietary Supplements
    Dysmenorrhea
    Erythrocyte Membrane
    Fatty Acids, Omega-6
    Female
    Fish Oils
    Humans
    Plant Oils
    Sunflower Oil
    Treatment Outcome
    gamma-Linolenic Acid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18296341

    Citation

    Wu, Chao-Chih, et al. "Metabolism of Omega-6 Polyunsaturated Fatty Acids in Women With Dysmenorrhea." Asia Pacific Journal of Clinical Nutrition, vol. 17 Suppl 1, 2008, pp. 216-9.
    Wu CC, Huang MY, Kapoor R, et al. Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. Asia Pac J Clin Nutr. 2008;17 Suppl 1:216-9.
    Wu, C. C., Huang, M. Y., Kapoor, R., Chen, C. H., & Huang, Y. S. (2008). Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. Asia Pacific Journal of Clinical Nutrition, 17 Suppl 1, pp. 216-9.
    Wu CC, et al. Metabolism of Omega-6 Polyunsaturated Fatty Acids in Women With Dysmenorrhea. Asia Pac J Clin Nutr. 2008;17 Suppl 1:216-9. PubMed PMID: 18296341.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. AU - Wu,Chao-Chih, AU - Huang,Mei-Yu, AU - Kapoor,Rakesh, AU - Chen,Chih-Hung, AU - Huang,Yung-Sheng, PY - 2008/5/28/pubmed PY - 2008/7/3/medline PY - 2008/5/28/entrez SP - 216 EP - 9 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 17 Suppl 1 N2 - Menstrual pain (dysmenorrhea) is one of the main complaints in clinics for women. The pain is often accompanied by other symptoms such as headache, nausea, constipation or diarrhea, urinary frequency, and vomiting which often leave the patients incapacitated for work or school for a few days. Dietary supplementation with polyunsaturated fatty acids (PUFA) has been shown to alleviate the menstrual pain. The purpose of the present study was to compare the effect of dietary supplementation with PUFA (sunflower seed oil, borage oil and fish oil concentrate) for three months on RBC membrane fatty acid composition in healthy and dysmenorrheica young women. Conversion of linoleic acid, via gamma-linolenic acid, to dihomo-gamma-linolenic acid (a precursor of anti-inflammatory prostaglandin E1) in dysmenorrheic subjects as compared to the controls was slower whereas the level of arachidonic acid (a precursor of pro-inflammatory PGE2) was not affected by the supplementation. Since there are no known side-effects associated with supplementation of these nutrients, management of dysmenorrhea through nutrition modulation should be an acceptable alternative to drug treatments. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/18296341/full_citation L2 - http://apjcn.nhri.org.tw/server/APJCN/17 Suppl 1//216.pdf DB - PRIME DP - Unbound Medicine ER -