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Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea.
Asia Pac J Clin Nutr 2008; 17 Suppl 1:216-9AP

Abstract

Menstrual pain (dysmenorrhea) is one of the main complaints in clinics for women. The pain is often accompanied by other symptoms such as headache, nausea, constipation or diarrhea, urinary frequency, and vomiting which often leave the patients incapacitated for work or school for a few days. Dietary supplementation with polyunsaturated fatty acids (PUFA) has been shown to alleviate the menstrual pain. The purpose of the present study was to compare the effect of dietary supplementation with PUFA (sunflower seed oil, borage oil and fish oil concentrate) for three months on RBC membrane fatty acid composition in healthy and dysmenorrheica young women. Conversion of linoleic acid, via gamma-linolenic acid, to dihomo-gamma-linolenic acid (a precursor of anti-inflammatory prostaglandin E1) in dysmenorrheic subjects as compared to the controls was slower whereas the level of arachidonic acid (a precursor of pro-inflammatory PGE2) was not affected by the supplementation. Since there are no known side-effects associated with supplementation of these nutrients, management of dysmenorrhea through nutrition modulation should be an acceptable alternative to drug treatments.

Authors+Show Affiliations

Department of Food Science and Biotechnology, National Chung Hsing University. 250 Kuo-Kuang Road, Taichung, Taiwan 402.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18296341

Citation

Wu, Chao-Chih, et al. "Metabolism of Omega-6 Polyunsaturated Fatty Acids in Women With Dysmenorrhea." Asia Pacific Journal of Clinical Nutrition, vol. 17 Suppl 1, 2008, pp. 216-9.
Wu CC, Huang MY, Kapoor R, et al. Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. Asia Pac J Clin Nutr. 2008;17 Suppl 1:216-9.
Wu, C. C., Huang, M. Y., Kapoor, R., Chen, C. H., & Huang, Y. S. (2008). Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. Asia Pacific Journal of Clinical Nutrition, 17 Suppl 1, pp. 216-9.
Wu CC, et al. Metabolism of Omega-6 Polyunsaturated Fatty Acids in Women With Dysmenorrhea. Asia Pac J Clin Nutr. 2008;17 Suppl 1:216-9. PubMed PMID: 18296341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. AU - Wu,Chao-Chih, AU - Huang,Mei-Yu, AU - Kapoor,Rakesh, AU - Chen,Chih-Hung, AU - Huang,Yung-Sheng, PY - 2008/5/28/pubmed PY - 2008/7/3/medline PY - 2008/5/28/entrez SP - 216 EP - 9 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 17 Suppl 1 N2 - Menstrual pain (dysmenorrhea) is one of the main complaints in clinics for women. The pain is often accompanied by other symptoms such as headache, nausea, constipation or diarrhea, urinary frequency, and vomiting which often leave the patients incapacitated for work or school for a few days. Dietary supplementation with polyunsaturated fatty acids (PUFA) has been shown to alleviate the menstrual pain. The purpose of the present study was to compare the effect of dietary supplementation with PUFA (sunflower seed oil, borage oil and fish oil concentrate) for three months on RBC membrane fatty acid composition in healthy and dysmenorrheica young women. Conversion of linoleic acid, via gamma-linolenic acid, to dihomo-gamma-linolenic acid (a precursor of anti-inflammatory prostaglandin E1) in dysmenorrheic subjects as compared to the controls was slower whereas the level of arachidonic acid (a precursor of pro-inflammatory PGE2) was not affected by the supplementation. Since there are no known side-effects associated with supplementation of these nutrients, management of dysmenorrhea through nutrition modulation should be an acceptable alternative to drug treatments. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/18296341/full_citation L2 - http://apjcn.nhri.org.tw/server/APJCN/17 Suppl 1//216.pdf DB - PRIME DP - Unbound Medicine ER -