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Genetics, clinical manifestations and management of FAP and HNPCC.
Med Arh. 2007; 61(4):256-9.MA

Abstract

Colorectal cancer occurs in the familial cancer syndromes in about 2 to 4 percent. The major genetic syndromes are Familial adenomatous polyposis (FAP) and Hereditary nonpolyposis colorectal cancer (HNPCC). FAP is caused by germline mutation of APC gene, and HNPCC is caused by germline mutation in one of five MMR genes. The identification of patients with inherited disease is very important in the management of colorectal cancer. But, it is impractical to test every patient with the disease for these mutations. The clinical and genetical screening programme should be advised for family members at risk and colectomy in affected individuals in purpose to reduce the frequency of colorectal cancer.

Authors+Show Affiliations

Gastroenterology Department, Clinic of Internal Diseases, University Clinical Center Tuzla, Bosnia and Herzegovina. dupavlov@bih.net.baNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18298004

Citation

Pavlovic-Calic, Nada, et al. "Genetics, Clinical Manifestations and Management of FAP and HNPCC." Medicinski Arhiv, vol. 61, no. 4, 2007, pp. 256-9.
Pavlovic-Calic N, Muminhodzic K, Zildzic M, et al. Genetics, clinical manifestations and management of FAP and HNPCC. Med Arh. 2007;61(4):256-9.
Pavlovic-Calic, N., Muminhodzic, K., Zildzic, M., Smajic, M., Gegic, A., Alibegovic, E., Salkic, N., Jovanovic, P., Basic, M., & Iljazovic, S. (2007). Genetics, clinical manifestations and management of FAP and HNPCC. Medicinski Arhiv, 61(4), 256-9.
Pavlovic-Calic N, et al. Genetics, Clinical Manifestations and Management of FAP and HNPCC. Med Arh. 2007;61(4):256-9. PubMed PMID: 18298004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics, clinical manifestations and management of FAP and HNPCC. AU - Pavlovic-Calic,Nada, AU - Muminhodzic,Kasim, AU - Zildzic,Muharem, AU - Smajic,Midhat, AU - Gegic,Adnan, AU - Alibegovic,Ervin, AU - Salkic,Nermin, AU - Jovanovic,Predrag, AU - Basic,Mirela, AU - Iljazovic,Samra, PY - 2008/2/27/pubmed PY - 2008/4/29/medline PY - 2008/2/27/entrez SP - 256 EP - 9 JF - Medicinski arhiv JO - Med Arh VL - 61 IS - 4 N2 - Colorectal cancer occurs in the familial cancer syndromes in about 2 to 4 percent. The major genetic syndromes are Familial adenomatous polyposis (FAP) and Hereditary nonpolyposis colorectal cancer (HNPCC). FAP is caused by germline mutation of APC gene, and HNPCC is caused by germline mutation in one of five MMR genes. The identification of patients with inherited disease is very important in the management of colorectal cancer. But, it is impractical to test every patient with the disease for these mutations. The clinical and genetical screening programme should be advised for family members at risk and colectomy in affected individuals in purpose to reduce the frequency of colorectal cancer. UR - https://www.unboundmedicine.com/medline/citation/18298004/Genetics_clinical_manifestations_and_management_of_FAP_and_HNPCC_ L2 - https://antibodies.cancer.gov/detail/CPTC-MLH1-1 DB - PRIME DP - Unbound Medicine ER -