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A role for sweet taste: calorie predictive relations in energy regulation by rats.

Abstract

Animals may use sweet taste to predict the caloric contents of food. Eating sweet noncaloric substances may degrade this predictive relationship, leading to positive energy balance through increased food intake and/or diminished energy expenditure. These experiments were designed to test the hypothesis that experiences that reduce the validity of sweet taste as a predictor of the caloric or nutritive consequences of eating may contribute to deficits in the regulation of energy by reducing the ability of sweet-tasting foods that contain calories to evoke physiological responses that underlie tight regulation. Adult male Sprague-Dawley rats were given differential experience with a sweet taste that either predicted increased caloric content (glucose) or did not predict increased calories (saccharin). We found that reducing the correlation between sweet taste and the caloric content of foods using artificial sweeteners in rats resulted in increased caloric intake, increased body weight, and increased adiposity, as well as diminished caloric compensation and blunted thermic responses to sweet-tasting diets. These results suggest that consumption of products containing artificial sweeteners may lead to increased body weight and obesity by interfering with fundamental homeostatic, physiological processes.

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  • Authors+Show Affiliations

    ,

    Department of Psychological Sciences, Ingestive Behavior Research Center, Purdue University, West Lafayette, IN 47907, USA. swithers@purdue.edu

    Source

    Behavioral neuroscience 122:1 2008 Feb pg 161-73

    MeSH

    Absorptiometry, Photon
    Adiposity
    Analysis of Variance
    Animals
    Appetite Regulation
    Behavior, Animal
    Body Temperature
    Body Weight
    Energy Intake
    Energy Metabolism
    Food Preferences
    Male
    Predictive Value of Tests
    Rats
    Rats, Sprague-Dawley
    Sweetening Agents
    Taste

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18298259

    Citation

    Swithers, Susan E., and Terry L. Davidson. "A Role for Sweet Taste: Calorie Predictive Relations in Energy Regulation By Rats." Behavioral Neuroscience, vol. 122, no. 1, 2008, pp. 161-73.
    Swithers SE, Davidson TL. A role for sweet taste: calorie predictive relations in energy regulation by rats. Behav Neurosci. 2008;122(1):161-73.
    Swithers, S. E., & Davidson, T. L. (2008). A role for sweet taste: calorie predictive relations in energy regulation by rats. Behavioral Neuroscience, 122(1), pp. 161-73. doi:10.1037/0735-7044.122.1.161.
    Swithers SE, Davidson TL. A Role for Sweet Taste: Calorie Predictive Relations in Energy Regulation By Rats. Behav Neurosci. 2008;122(1):161-73. PubMed PMID: 18298259.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A role for sweet taste: calorie predictive relations in energy regulation by rats. AU - Swithers,Susan E, AU - Davidson,Terry L, PY - 2008/2/27/pubmed PY - 2008/6/24/medline PY - 2008/2/27/entrez SP - 161 EP - 73 JF - Behavioral neuroscience JO - Behav. Neurosci. VL - 122 IS - 1 N2 - Animals may use sweet taste to predict the caloric contents of food. Eating sweet noncaloric substances may degrade this predictive relationship, leading to positive energy balance through increased food intake and/or diminished energy expenditure. These experiments were designed to test the hypothesis that experiences that reduce the validity of sweet taste as a predictor of the caloric or nutritive consequences of eating may contribute to deficits in the regulation of energy by reducing the ability of sweet-tasting foods that contain calories to evoke physiological responses that underlie tight regulation. Adult male Sprague-Dawley rats were given differential experience with a sweet taste that either predicted increased caloric content (glucose) or did not predict increased calories (saccharin). We found that reducing the correlation between sweet taste and the caloric content of foods using artificial sweeteners in rats resulted in increased caloric intake, increased body weight, and increased adiposity, as well as diminished caloric compensation and blunted thermic responses to sweet-tasting diets. These results suggest that consumption of products containing artificial sweeteners may lead to increased body weight and obesity by interfering with fundamental homeostatic, physiological processes. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/18298259/A_role_for_sweet_taste:_calorie_predictive_relations_in_energy_regulation_by_rats_ L2 - http://content.apa.org/journals/bne/122/1/161 DB - PRIME DP - Unbound Medicine ER -