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Acute liver failure in pregnancy: an overview.
Minerva Gastroenterol Dietol. 2008 Mar; 54(1):75-84.MG

Abstract

Acute liver failure (ALF) in pregnancy is a common challenging clinical problem both in terms of correct diagnosis and management. Acute viral hepatitis is the most common cause of jaundice in pregnancy. The course of acute viral hepatitis is unaffected by pregnancy, except in patients with hepatitis E (HEV), particularly from endemic countries like India, where ALF carries a high mortality. In both HEV infection and herpes simplex infections, maternal and fetal mortality rates are significantly increased. ALF specific to pregnancy including pre-eclampsia, associated with hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome, acute fatty liver of pregnancy, and hepatic infarction result in increased maternal and fetal mortality if not recognized and acted on early. Early recognition of possible causes and prompt treatment are crucial for successful outcome of ALF in pregnancy. Treatment involves prompt delivery, whereupon the liver disease quickly reverses. This review article addresses the present understanding of ALF in pregnancy reviewing the common causes of ALF and their management in pregnancy.

Authors+Show Affiliations

Stanley Medical College, Chennai, India. drjayanthi35@yahoo.co.inNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18299670

Citation

Jayanthi, V, and N Udayakumar. "Acute Liver Failure in Pregnancy: an Overview." Minerva Gastroenterologica E Dietologica, vol. 54, no. 1, 2008, pp. 75-84.
Jayanthi V, Udayakumar N. Acute liver failure in pregnancy: an overview. Minerva Gastroenterol Dietol. 2008;54(1):75-84.
Jayanthi, V., & Udayakumar, N. (2008). Acute liver failure in pregnancy: an overview. Minerva Gastroenterologica E Dietologica, 54(1), 75-84.
Jayanthi V, Udayakumar N. Acute Liver Failure in Pregnancy: an Overview. Minerva Gastroenterol Dietol. 2008;54(1):75-84. PubMed PMID: 18299670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute liver failure in pregnancy: an overview. AU - Jayanthi,V, AU - Udayakumar,N, PY - 2008/2/27/pubmed PY - 2008/9/5/medline PY - 2008/2/27/entrez SP - 75 EP - 84 JF - Minerva gastroenterologica e dietologica JO - Minerva Gastroenterol Dietol VL - 54 IS - 1 N2 - Acute liver failure (ALF) in pregnancy is a common challenging clinical problem both in terms of correct diagnosis and management. Acute viral hepatitis is the most common cause of jaundice in pregnancy. The course of acute viral hepatitis is unaffected by pregnancy, except in patients with hepatitis E (HEV), particularly from endemic countries like India, where ALF carries a high mortality. In both HEV infection and herpes simplex infections, maternal and fetal mortality rates are significantly increased. ALF specific to pregnancy including pre-eclampsia, associated with hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome, acute fatty liver of pregnancy, and hepatic infarction result in increased maternal and fetal mortality if not recognized and acted on early. Early recognition of possible causes and prompt treatment are crucial for successful outcome of ALF in pregnancy. Treatment involves prompt delivery, whereupon the liver disease quickly reverses. This review article addresses the present understanding of ALF in pregnancy reviewing the common causes of ALF and their management in pregnancy. SN - 1121-421X UR - https://www.unboundmedicine.com/medline/citation/18299670/Acute_liver_failure_in_pregnancy:_an_overview_ DB - PRIME DP - Unbound Medicine ER -