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Cytologic diagnosis of lobular carcinoma of the breast: experience with 555 patients in the Rene Huguenin Cancer Center.
Cancer. 2008 Apr 25; 114(2):111-7.C

Abstract

BACKGROUND

Fine-needle aspiration generally produces results that are not as good for lobular carcinoma as the results for ductal carcinoma of the breast. In this study, the authors evaluated their team's performance in cytologic diagnosis of lobular carcinoma over 11 years and analyzed the reasons for diagnostic failure.

METHODS

Cytologic findings were analyzed in 555 consecutive fine-needle cytopuncture specimens from women with palpable, invasive lobular carcinoma of the breast. The authors also examined the influence of the cytologist's experience, the clinical tumor size, the histologic subtype, and the histologic grade on diagnostic performance. All negative samples were re-examined, along with all samples that had been obtained during the last year of the study, to refine the morphologic description of lobular carcinoma.

RESULTS

Malignancy was diagnosed in 68.8% of specimens overall. The individual pathologists diagnosed malignancy in from 44.4% to 81.1% of specimens, depending on their experience. Diagnostic performance was correlated with clinical tumor size, histologic grade, and histologic subtype, and correct diagnoses were significantly more frequent in pleomorphic subtypes than in "classic" types. Re-examination of all 32 negative specimens reduced the false-negative rate from 5.8% to 3.8%.

CONCLUSIONS

Despite the pitfalls associated with lobular carcinoma of the breast, fine-needle cytopuncture remains a useful diagnostic tool before treatment. Failures can be reduced through experience and by better knowledge of cytologic features.

Authors+Show Affiliations

Department of Pathology, René Huguenin Center, St. Cloud, France. menet@crh1.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18300231

Citation

Menet, Emmanuelle, et al. "Cytologic Diagnosis of Lobular Carcinoma of the Breast: Experience With 555 Patients in the Rene Huguenin Cancer Center." Cancer, vol. 114, no. 2, 2008, pp. 111-7.
Menet E, Becette V, Briffod M. Cytologic diagnosis of lobular carcinoma of the breast: experience with 555 patients in the Rene Huguenin Cancer Center. Cancer. 2008;114(2):111-7.
Menet, E., Becette, V., & Briffod, M. (2008). Cytologic diagnosis of lobular carcinoma of the breast: experience with 555 patients in the Rene Huguenin Cancer Center. Cancer, 114(2), 111-7. https://doi.org/10.1002/cncr.23347
Menet E, Becette V, Briffod M. Cytologic Diagnosis of Lobular Carcinoma of the Breast: Experience With 555 Patients in the Rene Huguenin Cancer Center. Cancer. 2008 Apr 25;114(2):111-7. PubMed PMID: 18300231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytologic diagnosis of lobular carcinoma of the breast: experience with 555 patients in the Rene Huguenin Cancer Center. AU - Menet,Emmanuelle, AU - Becette,Véronique, AU - Briffod,Marianne, PY - 2008/2/27/pubmed PY - 2008/6/5/medline PY - 2008/2/27/entrez SP - 111 EP - 7 JF - Cancer JO - Cancer VL - 114 IS - 2 N2 - BACKGROUND: Fine-needle aspiration generally produces results that are not as good for lobular carcinoma as the results for ductal carcinoma of the breast. In this study, the authors evaluated their team's performance in cytologic diagnosis of lobular carcinoma over 11 years and analyzed the reasons for diagnostic failure. METHODS: Cytologic findings were analyzed in 555 consecutive fine-needle cytopuncture specimens from women with palpable, invasive lobular carcinoma of the breast. The authors also examined the influence of the cytologist's experience, the clinical tumor size, the histologic subtype, and the histologic grade on diagnostic performance. All negative samples were re-examined, along with all samples that had been obtained during the last year of the study, to refine the morphologic description of lobular carcinoma. RESULTS: Malignancy was diagnosed in 68.8% of specimens overall. The individual pathologists diagnosed malignancy in from 44.4% to 81.1% of specimens, depending on their experience. Diagnostic performance was correlated with clinical tumor size, histologic grade, and histologic subtype, and correct diagnoses were significantly more frequent in pleomorphic subtypes than in "classic" types. Re-examination of all 32 negative specimens reduced the false-negative rate from 5.8% to 3.8%. CONCLUSIONS: Despite the pitfalls associated with lobular carcinoma of the breast, fine-needle cytopuncture remains a useful diagnostic tool before treatment. Failures can be reduced through experience and by better knowledge of cytologic features. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/18300231/Cytologic_diagnosis_of_lobular_carcinoma_of_the_breast:_experience_with_555_patients_in_the_Rene_Huguenin_Cancer_Center_ L2 - https://doi.org/10.1002/cncr.23347 DB - PRIME DP - Unbound Medicine ER -