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[Potential role of microRNAs in human diseases and the exploration on design of small molecule agents].
Yao Xue Xue Bao. 2007 Nov; 42(11):1115-21.YX

Abstract

MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene modulation by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. miRNA alterations are involved in the initiation and progression of human diseases. miRNA-expression profiling of human diseases has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. Recent evidence has suggested miRNAs as viable therapeutic targets for a wide range of human diseases. Several approaches were performed, the experimental examination of these techniques and the resultant findings not only indicate feasibility of interfering miRNA action in a gene-specific fashion but also may provide a new research tool for studying function of miRNAs. The new approaches also have the potential of becoming alternative gene therapy strategies.

Authors+Show Affiliations

Zhang Y
Department of Pharmacology, Incubator of State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Harbin Medical University, Harbin 150081, China.
Lu YJ
No affiliation info available
Yang BF
No affiliation info available

MeSH

AnimalsDrug DesignGene Expression ProfilingGene Expression RegulationGene SilencingGenetic TherapyHeart DiseasesHumansHypertensionMicroRNAsNeoplasmsRNA, Messenger

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

chi

PubMed ID

18300464

Citation

Zhang, Yong, et al. "[Potential Role of microRNAs in Human Diseases and the Exploration On Design of Small Molecule Agents]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 42, no. 11, 2007, pp. 1115-21.
Zhang Y, Lu YJ, Yang BF. [Potential role of microRNAs in human diseases and the exploration on design of small molecule agents]. Yao Xue Xue Bao. 2007;42(11):1115-21.
Zhang, Y., Lu, Y. J., & Yang, B. F. (2007). [Potential role of microRNAs in human diseases and the exploration on design of small molecule agents]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 42(11), 1115-21.
Zhang Y, Lu YJ, Yang BF. [Potential Role of microRNAs in Human Diseases and the Exploration On Design of Small Molecule Agents]. Yao Xue Xue Bao. 2007;42(11):1115-21. PubMed PMID: 18300464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Potential role of microRNAs in human diseases and the exploration on design of small molecule agents]. AU - Zhang,Yong, AU - Lu,Yan-jie, AU - Yang,Bao-feng, PY - 2008/2/28/pubmed PY - 2009/8/7/medline PY - 2008/2/28/entrez SP - 1115 EP - 21 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 42 IS - 11 N2 - MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene modulation by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. miRNA alterations are involved in the initiation and progression of human diseases. miRNA-expression profiling of human diseases has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. Recent evidence has suggested miRNAs as viable therapeutic targets for a wide range of human diseases. Several approaches were performed, the experimental examination of these techniques and the resultant findings not only indicate feasibility of interfering miRNA action in a gene-specific fashion but also may provide a new research tool for studying function of miRNAs. The new approaches also have the potential of becoming alternative gene therapy strategies. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/18300464/[Potential_role_of_microRNAs_in_human_diseases_and_the_exploration_on_design_of_small_molecule_agents]_ DB - PRIME DP - Unbound Medicine ER -