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[Structure modification on sesquiterpene lactones from Elephantopus scaber].
Yao Xue Xue Bao. 2007 Nov; 42(11):1159-61.YX

Abstract

In order to look for lower toxic and strongly active compounds, the structure of sesquiterpene lactones from Elephantopus scaber was modified. Deoxyelephantopin and scabertopin were isolated from the whole plant of Elephantopus scaber and hydrogenated and epoxidated. Five sesquiterpenoide derivatives were prepared and their structures were identified by IR, NMR and MS spectra analysis. Four sesquiterpenoides are new compounds. Part of the compounds show definite antitumor activity.

Authors+Show Affiliations

Liang QL
Nanjing University of Chinese Medicine, Nanjing 210046, China. liangqiaoli@sohu.com
Min ZD
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicAsteraceaeHeLa CellsHumansHydrogenationLactonesMolecular StructurePlants, MedicinalSesquiterpenesTerpenes

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18300472

Citation

Liang, Qiao-li, and Zhi-da Min. "[Structure Modification On Sesquiterpene Lactones From Elephantopus Scaber]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 42, no. 11, 2007, pp. 1159-61.
Liang QL, Min ZD. [Structure modification on sesquiterpene lactones from Elephantopus scaber]. Yao Xue Xue Bao. 2007;42(11):1159-61.
Liang, Q. L., & Min, Z. D. (2007). [Structure modification on sesquiterpene lactones from Elephantopus scaber]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 42(11), 1159-61.
Liang QL, Min ZD. [Structure Modification On Sesquiterpene Lactones From Elephantopus Scaber]. Yao Xue Xue Bao. 2007;42(11):1159-61. PubMed PMID: 18300472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Structure modification on sesquiterpene lactones from Elephantopus scaber]. AU - Liang,Qiao-li, AU - Min,Zhi-da, PY - 2008/2/28/pubmed PY - 2009/8/7/medline PY - 2008/2/28/entrez SP - 1159 EP - 61 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 42 IS - 11 N2 - In order to look for lower toxic and strongly active compounds, the structure of sesquiterpene lactones from Elephantopus scaber was modified. Deoxyelephantopin and scabertopin were isolated from the whole plant of Elephantopus scaber and hydrogenated and epoxidated. Five sesquiterpenoide derivatives were prepared and their structures were identified by IR, NMR and MS spectra analysis. Four sesquiterpenoides are new compounds. Part of the compounds show definite antitumor activity. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/18300472/[Structure_modification_on_sesquiterpene_lactones_from_Elephantopus_scaber]_ DB - PRIME DP - Unbound Medicine ER -