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Neuropathology of the substantia nigra.
Eur Neurol. 1991; 31 Suppl 1:48-59.EN

Abstract

Neuronal subpopulations of the substantia nigra pars compacta can be separated into two functionally distinct nigrostriatal projections, the ventral tier which is poorly melanised, and the dorsal tier which is well melanised. In Parkinson's disease, juvenile-onset parkinsonism with dystonia and striatonigral degeneration the ventral tier is more vulnerable than the dorsal tier. The ventral tier mostly projects to the putamen, which is vulnerable in striatonigral degeneration and Huntington's disease. In Huntington's disease spiny neurons of the striatal matrix and neurons of the pars reticulata are particularly susceptible. Determining patterns of selective neuronal death may lead to identification of pathogenetic mechanisms.

Authors+Show Affiliations

University Department of Neurology, King's College School of Medicine and Dentistry, London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1830274

Citation

Gibb, W R.. "Neuropathology of the Substantia Nigra." European Neurology, vol. 31 Suppl 1, 1991, pp. 48-59.
Gibb WR. Neuropathology of the substantia nigra. Eur Neurol. 1991;31 Suppl 1:48-59.
Gibb, W. R. (1991). Neuropathology of the substantia nigra. European Neurology, 31 Suppl 1, 48-59.
Gibb WR. Neuropathology of the Substantia Nigra. Eur Neurol. 1991;31 Suppl 1:48-59. PubMed PMID: 1830274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropathology of the substantia nigra. A1 - Gibb,W R, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 48 EP - 59 JF - European neurology JO - Eur Neurol VL - 31 Suppl 1 N2 - Neuronal subpopulations of the substantia nigra pars compacta can be separated into two functionally distinct nigrostriatal projections, the ventral tier which is poorly melanised, and the dorsal tier which is well melanised. In Parkinson's disease, juvenile-onset parkinsonism with dystonia and striatonigral degeneration the ventral tier is more vulnerable than the dorsal tier. The ventral tier mostly projects to the putamen, which is vulnerable in striatonigral degeneration and Huntington's disease. In Huntington's disease spiny neurons of the striatal matrix and neurons of the pars reticulata are particularly susceptible. Determining patterns of selective neuronal death may lead to identification of pathogenetic mechanisms. SN - 0014-3022 UR - https://www.unboundmedicine.com/medline/citation/1830274/Neuropathology_of_the_substantia_nigra_ L2 - https://www.karger.com?DOI=10.1159/000116721 DB - PRIME DP - Unbound Medicine ER -