Tags

Type your tag names separated by a space and hit enter

The effect of latanoprost, bimatoprost, and travoprost on circadian variation of intraocular pressure in patients with open-angle glaucoma.
J Glaucoma. 2008 Jan-Feb; 17(1):36-9.JG

Abstract

PURPOSE

To evaluate the efficacy of latanoprost, bimatoprost, and travoprost given in the evening over the 24-hour curve in newly diagnosed open-angle glaucoma patients.

METHODS

This 8-week, randomized, parallel group, masked evaluator study compared the efficacy of once daily administration of latanoprost 0.005%, bimatoprost 0.03%, and travoprost 0.004% ophthalmic solutions. After enrollment at baseline, 48 patients were randomized to 3 treatment groups: latanoprost (n=17), bimatoprost (n=16), and travoprost (n=15). At baseline and 8 weeks of therapy, masked evaluators measured intraocular pressure (IOP) at 8 AM, 10 AM, 1 PM, 4 PM, 8 PM, 11 PM, and 3 AM.

RESULTS

Baseline mean IOP levels were similar across the groups. By week 8, reductions were observed in all 3 groups (P<0.001 for each). Travoprost-treated patients' IOP levels were reduced 8.7 and 8.1 mm Hg at 8 and 10 AM, respectively. Latanoprost-treated patients experienced 4.8 and 5.3 mm Hg reductions, whereas bimatoprost-treated patients experienced 5.5 and 4.9 mm Hg reductions at these time points. The amount of IOP reduction seen at 8 and 10 AM in travoprost group was significantly higher when compared with latanoprost and bimatoprost-treated group (P<0.001).

CONCLUSIONS

Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in open-angle glaucoma patients. On the basis of our data, the IOP reduction of these drugs is indistinguishable within statistical parameters.

Authors+Show Affiliations

Department of Ophthalmology, Eskisehir Osmangazi University Hospital, Eskisehir, Turkey. nyyildirim@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18303382

Citation

Yildirim, Nilgun, et al. "The Effect of Latanoprost, Bimatoprost, and Travoprost On Circadian Variation of Intraocular Pressure in Patients With Open-angle Glaucoma." Journal of Glaucoma, vol. 17, no. 1, 2008, pp. 36-9.
Yildirim N, Sahin A, Gultekin S. The effect of latanoprost, bimatoprost, and travoprost on circadian variation of intraocular pressure in patients with open-angle glaucoma. J Glaucoma. 2008;17(1):36-9.
Yildirim, N., Sahin, A., & Gultekin, S. (2008). The effect of latanoprost, bimatoprost, and travoprost on circadian variation of intraocular pressure in patients with open-angle glaucoma. Journal of Glaucoma, 17(1), 36-9. https://doi.org/10.1097/IJG.0b013e318133fb70
Yildirim N, Sahin A, Gultekin S. The Effect of Latanoprost, Bimatoprost, and Travoprost On Circadian Variation of Intraocular Pressure in Patients With Open-angle Glaucoma. J Glaucoma. 2008 Jan-Feb;17(1):36-9. PubMed PMID: 18303382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of latanoprost, bimatoprost, and travoprost on circadian variation of intraocular pressure in patients with open-angle glaucoma. AU - Yildirim,Nilgun, AU - Sahin,Afsun, AU - Gultekin,Saadet, PY - 2008/2/28/pubmed PY - 2008/4/9/medline PY - 2008/2/28/entrez SP - 36 EP - 9 JF - Journal of glaucoma JO - J. Glaucoma VL - 17 IS - 1 N2 - PURPOSE: To evaluate the efficacy of latanoprost, bimatoprost, and travoprost given in the evening over the 24-hour curve in newly diagnosed open-angle glaucoma patients. METHODS: This 8-week, randomized, parallel group, masked evaluator study compared the efficacy of once daily administration of latanoprost 0.005%, bimatoprost 0.03%, and travoprost 0.004% ophthalmic solutions. After enrollment at baseline, 48 patients were randomized to 3 treatment groups: latanoprost (n=17), bimatoprost (n=16), and travoprost (n=15). At baseline and 8 weeks of therapy, masked evaluators measured intraocular pressure (IOP) at 8 AM, 10 AM, 1 PM, 4 PM, 8 PM, 11 PM, and 3 AM. RESULTS: Baseline mean IOP levels were similar across the groups. By week 8, reductions were observed in all 3 groups (P<0.001 for each). Travoprost-treated patients' IOP levels were reduced 8.7 and 8.1 mm Hg at 8 and 10 AM, respectively. Latanoprost-treated patients experienced 4.8 and 5.3 mm Hg reductions, whereas bimatoprost-treated patients experienced 5.5 and 4.9 mm Hg reductions at these time points. The amount of IOP reduction seen at 8 and 10 AM in travoprost group was significantly higher when compared with latanoprost and bimatoprost-treated group (P<0.001). CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in open-angle glaucoma patients. On the basis of our data, the IOP reduction of these drugs is indistinguishable within statistical parameters. SN - 1057-0829 UR - https://www.unboundmedicine.com/medline/citation/18303382/The_effect_of_latanoprost_bimatoprost_and_travoprost_on_circadian_variation_of_intraocular_pressure_in_patients_with_open_angle_glaucoma_ L2 - http://dx.doi.org/10.1097/IJG.0b013e318133fb70 DB - PRIME DP - Unbound Medicine ER -